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Ciliary body toxicity of cyclosporin A and octreotide acetate in rabbit eyes: a comparison with mitomycin C and 5-fluorouracil

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Abstract

Purpose

To compare the toxicities of cyclosporin A, octreotide acetate, mitomycin C and 5-fluorouracil to the ciliary body.

Method

We applied sponges soaked in these compounds to the open scleras of rabbit eyes. Histopathological specimens were obtained from the operation site and at 180°  from it on the 14th day after surgery.

Results

Mean ciliary epithelial thickness in the study groups was as follows: 12.29±2.69 μm in group 1 (mitomycin C), 13.85±4.56 μm in group 2 (5-fluorouracil), 17.71±3.09 μm in group 3 (cyclosporin A), 11.64±2.92 μm in group 4 (octreotide acetate), 11.92±2.89 μm in group 5 (topically applied octreotide acetate) and 21.85±4.29 μm in group 6 (control). The ciliary epithelial thickness in groups 1, 2, 4 and 5 was statistically different from that in the control group. Intracellular vacuolisation and degenerative changes of the non-pigmented epithelium, and pigment loss of the pigmented epithelium, were found mostly in group 1 and moderately in group 2 and 3.

Conclusion

Octreotide acetate and cyclosporin A are less toxic alternatives to mitomycin C and 5-fluorouracil in glaucoma filtration surgery.

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Fig. 1a, b. Fig. 2a, b. Fig. 3. Fig. 4. Fig. 5. Fig. 6.

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Authors and Affiliations

  1. Department of Ophthalmology, Fırat University Medical School, Göz Hastalıkları AD, 23200 , Elazıg, Turkey

    Nuray Akyol, Tamer Demir & Fatih Ulaş

  2. Department of Pathology, Fırat University Medical School, Elazıg, Turkey

    Bengu Çobanoglu

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  1. Nuray Akyol
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  2. Tamer Demir
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  3. Bengu Çobanoglu
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  4. Fatih Ulaş
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Correspondence to Nuray Akyol.

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Akyol, N., Demir, T., Çobanoglu, B. et al. Ciliary body toxicity of cyclosporin A and octreotide acetate in rabbit eyes: a comparison with mitomycin C and 5-fluorouracil. Graefe's Arch Clin Exp Ophthalmol 241, 816–822 (2003). https://doi.org/10.1007/s00417-003-0717-6

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  • DOI: https://doi.org/10.1007/s00417-003-0717-6

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