Abstract
We evaluated the effect of l-threo-3,4-dihydroxyphenylserine (l-threo-DOPS) on the response of blood pressure and vasoactive factors during head-up tilt in patients with multiple system atrophy (MSA). After the daily oral administration of 300 mg l-threo-DOPS for 2 weeks we observed a significant reduction in the decline of systolic blood pressure during 60° head-up-tilt. In concordance with this result, we detected significant increases in postural changes in plasma renin activity and angiotensin II following l-threo-DOPS treatment. The enhanced responses of these vasoactive mediators by l-threo-DOPS during head-up tilt may contribute to the improvement in orthostatic hypotension in patients with MSA.
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Received: 6 December 1997 Received in revised form: 5 May 1998 Accepted: 17 June 1998
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Yoshizawa, T., Fujita, T., Mizusawa, H. et al. l-threo-3,4-dihydroxyphenylserine enhances the orthostatic responses of plasma renin activity and angiotensin II in multiple system atrophy. J Neurol 246, 193–197 (1999). https://doi.org/10.1007/s004150050333
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DOI: https://doi.org/10.1007/s004150050333