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Reversible parkinsonism induced by prolonged treatment with valproate

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Abstract

We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures. Parkinsonism disappeared in less than 3 months after VPA substitution with carbamazepine.

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Authors and Affiliations

  1. Dipartimento di Oncologia e Neuroscienze, Clinica Neurologica, via dei Vestini, I-66100 Chieti, Italy e-mail: onofrj@ibmpe.unich.it Tel.: +39-871-358527 Fax: +39-871-562019, , , , , , IT

    M. Onofrj, Astrid Thomas & Cristina Paci

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  1. M. Onofrj
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  2. Astrid Thomas
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  3. Cristina Paci
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Received: 1 December 1997 Received in revised form: 27 March 1998 Accepted: 8 April 1998

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Onofrj, M., Thomas, A. & Paci, C. Reversible parkinsonism induced by prolonged treatment with valproate. J Neurol 245, 794–796 (1998). https://doi.org/10.1007/s004150050288

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  • DOI: https://doi.org/10.1007/s004150050288

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