Skip to main content

Advertisement

SpringerLink
Log in

Progressive multifocal leukoencephalopathy in patients with chronic liver disease successfully treated with pembrolizumab

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Schweitzer F, Laurent S, Cortese I et al (2023) Progressive multifocal leukoencephalopathy: pathogenesis, diagnostic tools, and potential biomarkers of response to therapy. Neurology 101:700–713. https://doi.org/10.1212/WNL.0000000000207622

    Article  CAS  PubMed  Google Scholar 

  2. Cortese I, Muranski P, Enose-Akahata Y et al (2019) Pembrolizumab treatment for progressive multifocal leukoencephalopathy. N Engl J Med 380:1597–1605. https://doi.org/10.1056/NEJMoa1815039

    Article  CAS  PubMed  Google Scholar 

  3. Roos-Weil D, Weiss N, Guihot A et al (2021) Immune checkpoint inhibitors for progressive multifocal leukoencephalopathy: a new gold standard? J Neurol 268:2458–2465. https://doi.org/10.1007/s00415-021-10414-y

    Article  CAS  PubMed  Google Scholar 

  4. Boumaza X, Bonneau B, Roos‐Weil D, et al (2022) Progressive Multifocal Leukoencephalopathy Treated by Immune Checkpoint Inhibitors. Ann Neurol 15: 10. Doi: https://doi.org/10.1002/ana.26512

  5. Barber DL, Wherry EJ, Masopust D et al (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682–687. https://doi.org/10.1038/nature04444

    Article  CAS  PubMed  Google Scholar 

  6. Girón-González JA, Alvarez-Mon M, Menéndez-Caro JL et al (1994) T lymphocytes from alcoholic cirrhotic patients show normal interleukin-2 production but a defective proliferative response to polyclonal mitogens. Am J Gastroenterol 89:767–773

    PubMed  Google Scholar 

  7. Gomez F, Ruiz P, Schreiber AD (1994) Impaired Function of Macrophage Fcγ Receptors and Bacterial Infection in Alcoholic Cirrhosis. N Engl J Med 331:1122–1128. https://doi.org/10.1056/NEJM199410273311704

    Article  CAS  PubMed  Google Scholar 

  8. Laso FJ, Madruga JI, Giron JA et al (1997) Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption. Hepatology 25:1096–1100. https://doi.org/10.1002/hep.510250508

    Article  CAS  PubMed  Google Scholar 

  9. Acket B, Guillaume M, Tardy J et al (2010) Progressive multifocal leukoencephalopathy in a patient with alcoholic cirrhosis. Gastroenterol Clin Biol 34:336–338. https://doi.org/10.1016/j.gcb.2010.02.002

    Article  CAS  PubMed  Google Scholar 

  10. Gheuens S, Pierone G, Peeters P, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 81:247–254. https://doi.org/10.1136/jnnp.2009.187666

    Article  PubMed  Google Scholar 

  11. Berger JR, Aksamit AJ, Clifford DB et al (2013) PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology 80:1430–1438. https://doi.org/10.1212/WNL.0b013e31828c2fa1

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This study did not receive any funding.

Author information

Authors and Affiliations

  1. Département de Neurologie, Sorbonne Université, Médecine Intensive Réanimation à Orientation Neurologique, AP-HP.Sorbonne Université, Hôpital Pitié-Salpêtrière, 47-83, Boulevard de L’hôpital, 75013, Paris, France

    Lina Jeantin & Nicolas Weiss

  2. Department of Neuroradiology, Pitié–Salpétrière University Hospital, AP-HP, 47-83 bd de L’hôpital, 75013, Paris, France

    Natalia Shor

  3. Department of Neurology, CHIC Quimper-Concarneau, 14 Avenue Yves Thépot - BP 1757, 29107, Quimper, Cedex, France

    Marc Coustans

  4. Sorbonne Université, Department of Clinical Hematology, Pitié–Salpétrière University Hospital, AP-HP, 47-83 bd de L’hôpital, 75013, Paris, France

    Damien Roos-Weil

  5. Département de Pathologie Cellulaire et Tissulaire, CHRU Brest, Brest, France

    Isabelle Quintin-Roué

  6. Pharmacie hospitalière, Sorbonne Université, AP-HP, Hôpital Pitié Salpêtrière, 75013, Paris, France

    Agnès Bellanger

  7. Department of Biological Hematology, Pitié–Salpétrière University Hospital, AP-HP, 47-83 bd de L’hôpital, 75013, Paris, France

    Magali Le Garff-Tavernier

  8. Brain Liver Salpêtrière Study Group, Sorbonne Université, INSERM UMR_S 938, Centre de Recherche Saint-Antoine & Institute of Cardiometabolism and Nutrition (ICAN), 75013, Paris, France

    Dominique Thabut

  9. Liver Intensive Care Unit, Hepatogastroenterology Department, AP-HP, Sorbonne Université, Pitié-Salpêtrière Hospital, 47-83 Boulevard de L’Hôpital, 75013, Paris, France

    Rahma Ben Jemaa & Dominique Thabut

  10. Sorbonne Université, 75005, Paris, France

    Rahma Ben Jemaa, Dominique Thabut & Valérie Pourcher

  11. Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), AP-HP, Hôpital Pitié Salpêtrière, Service Des Maladies Infectieuses et Tropicales, Paris, France

    Valérie Pourcher

  12. Brain Liver Pitié-Salpêtrière (BLIPS) Study Group, INSERM UMR_S 938, Centre de Recherche Saint-Antoine, Maladies Métaboliques, Biliaires et Fibro-Inflammatoire du Foie, Institute of Cardiometabolism and Nutrition (ICAN), Paris, France

    Nicolas Weiss

  13. Groupe de Recherche Clinique en REanimation et Soins Intensifs du Patient en Insuffisance Respiratoire aiguE (GRC-RESPIRE) Sorbonne Université, Paris, France

    Nicolas Weiss

Authors
  1. Lina Jeantin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Natalia Shor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marc Coustans
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Damien Roos-Weil
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Isabelle Quintin-Roué
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Agnès Bellanger
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Magali Le Garff-Tavernier
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Rahma Ben Jemaa
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Dominique Thabut
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Valérie Pourcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Nicolas Weiss
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

LJ wrote the first draft of the manuscript. NS and LJ designed the figures. All authors participated in the diagnosis and therapy deliberation. All authors reviewed and approved the final manuscript. The patients provided informed consent for the publication of this report. Data was collected and managed in accordance with the CARE statement checklist (https://www.care-statement.org/checklist).

Corresponding author

Correspondence to Nicolas Weiss.

Ethics declarations

Conflicts of interest

The authors have no conflict of interest to declare.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 13 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jeantin, L., Shor, N., Coustans, M. et al. Progressive multifocal leukoencephalopathy in patients with chronic liver disease successfully treated with pembrolizumab. J Neurol 271, 2119–2124 (2024). https://doi.org/10.1007/s00415-023-12163-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-023-12163-6

Search

Navigation