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Conceptual design of a biped-wheeled wearable machine for ALS patients

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Funding

This work was partially funded by ERC European Project H2020 with acronym “ARS”, Autonomous Robotic Surgery, Project Number 742671, CUP B32F17000570006.

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Author notes

  1. Andrea Calvo and Antonio Canosa contributed equally to this work.

Authors and Affiliations

  1. Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy

    Giovanni Gerardo Muscolo & Paolo Fiorini

  2. ALS Centre, ‘Rita Levi Montalcini’ Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy

    Francesca Di Pede, Luca Solero, Adriano Chiò, Andrea Calvo & Antonio Canosa

  3. Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy

    Angelo Nicolì & Alessandra Russo

  4. SC Neurologia 1U, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy

    Adriano Chiò, Andrea Calvo & Antonio Canosa

  5. Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy

    Adriano Chiò & Antonio Canosa

  6. Neuroscience Institute of Turin (NIT), Turin, Italy

    Adriano Chiò & Andrea Calvo

Authors
  1. Giovanni Gerardo Muscolo
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  2. Francesca Di Pede
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  3. Luca Solero
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  4. Angelo Nicolì
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  5. Alessandra Russo
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  6. Paolo Fiorini
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  7. Adriano Chiò
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  8. Andrea Calvo
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  9. Antonio Canosa
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Contributions

Engineering: AN and GGM conceived the multibody models; AN implemented the first version of the multibody simulation; AR and GGM conceived the human interfaces for the biped-wheeled exoskeleton; AR designed the human interfaces for trunk and feet; GGM conceived, proposed, and started the research topic idea conceiving the biped-wheeled exoskeleton system, managing and supervising the research work from the engineering point of view; GGM, AN, AR, and PF read, revised, and contributed to the article and approved the submitted version. Medical authors: FDP, LS, ACh, ACal, and ACan drafted the work and revised it critically for important intellectual content; FDP, LS, ACal, and ACan performed the review of literature; ACan and ACal supervised the study.

Corresponding author

Correspondence to Antonio Canosa.

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Conflicts of interest

Giovanni Gerardo Muscolo, Antonio Canosa, Francesca Di Pede, Luca Solero, Angelo Nicolì, Alessandra Russo, and Paolo Fiorini declare that they have no conflict of interest. Andrea Calvo has received a research grant from Cytokinetics. Adriano Chiò serves on scientific advisory boards for Mitsubishi Tanabe, Roche, Biogen, Cytokinetics, Denali Therapeutics, Amylyx, and AveXis.

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Muscolo, G.G., Di Pede, F., Solero, L. et al. Conceptual design of a biped-wheeled wearable machine for ALS patients. J Neurol 270, 3632–3636 (2023). https://doi.org/10.1007/s00415-023-11678-2

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  • DOI: https://doi.org/10.1007/s00415-023-11678-2

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