Skip to main content

Advertisement

Log in

Health-related quality of life in Japanese patients with multiple sclerosis

  • Original Communication
  • Published:
Journal of Neurology Aims and scope Submit manuscript
  • 1 Altmetric

Abstract

Objectives

Neurological disabilities, especially physical issues, can adversely affect the daily lives of people with multiple sclerosis (MS) and negatively impact their health-related quality of life (HRQOL). On the other hand, physical and psychiatric symptoms are variable in people with MS, and QOL can be influenced by cultural and educational background. This study aimed to evaluate the association of HRQOL with disabilities, fatigue, and depression in Japanese subjects with MS.

Methods

Evaluation of HRQOL, fatigue, and depression was performed in 184 Japanese individuals with MS, using the Functional Assessment of MS (FAMS), Fatigue Severity Scale (FSS), and Beck Depression Inventory-Second Edition (BDI-II), respectively.

Results

Multiple linear regression analysis demonstrated negative correlations of the Expanded Disability Status Scale (EDSS) with scores on the FAMS subscales of mobility, symptoms, thinking and fatigue, total FAMS, and additional concerns. The FSS score had negative correlations with mobility, symptoms, emotional well-being, thinking and fatigue, total FAMS, and additional concerns. There were negative correlations between BDI-II scores and all items of FAMS.

Conclusions

HRQOL had relatively close correlations with disabilities and fatigue, and depression had an especially close relationship with HRQOL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Oliva Ramirez A, Keenan A, Kalau O et al (2021) Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review. BMC Neurol 21:468. https://doi.org/10.1186/s12883-021-02396-1

    Article  Google Scholar 

  2. Benito-León J, Morales JM, Rivera-Navarro J et al (2003) A review about the impact of multiple sclerosis on health-related quality of life. Disabil Rehabil 25:1291–1303. https://doi.org/10.1080/09638280310001608591

    Article  Google Scholar 

  3. Gil-González I, Martín-Rodríguez A, Conrad R et al (2020) Quality of life in adults with multiple sclerosis: a systematic review. BMJ Open 10:e041249. https://doi.org/10.1136/bmjopen-2020-041249

    Article  Google Scholar 

  4. Riemsma RP, Forbes CA, Glanville JM et al (2001) General health status measures for people with cognitive impairment: learning disability and acquired brain injury. Health Technol Assess 5:1–100. https://doi.org/10.3310/hta5060

    Article  CAS  Google Scholar 

  5. Wiebe S, Guyatt G, Weaver B et al (2003) Comparative responsiveness of generic and specific quality-of-life instruments. J Clin Epidemiol 56:52–60. https://doi.org/10.1016/s0895-4356(02)00537-1

    Article  Google Scholar 

  6. Cella DF, Dineen K, Arnason B et al (1996) Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology 47:129–139. https://doi.org/10.1212/wnl.47.1.129

    Article  CAS  Google Scholar 

  7. Kikuchi H, Mifune N, Niino M et al (2011) Impact and characteristics of quality of life in Japanese patients with multiple sclerosis. Qual Life Res 20:119–131. https://doi.org/10.1007/s11136-010-9725-2

    Article  Google Scholar 

  8. Multiple Sclerosis Clinical Practice Guidelines (1998) Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis. Paralyzed Veterans of America, Washington

    Google Scholar 

  9. Schmidt S, Jöstingmeyer P (2019) Depression, fatigue and disability are independently associated with quality of life in patients with multiple Sclerosis: results of a cross-sectional study. Mult Scler Relat Disord 35:262–269. https://doi.org/10.1016/j.msard.2019.07.029

    Article  Google Scholar 

  10. Kagawa-Singer M, Padilla GV, Ashing-Giwa K (2010) Health-related quality of life and culture. Semin Oncol Nurs 26:59–67. https://doi.org/10.1016/j.soncn.2009.11.008

    Article  Google Scholar 

  11. Thompson AJ, Banwell BL, Barkhof F et al (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17:162–173. https://doi.org/10.1016/S1474-4422(17)30470-2

    Article  Google Scholar 

  12. Wingerchuk DM, Banwell B, Bennett JL et al (2015) International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 85:177–189. https://doi.org/10.1212/WNL.0000000000001729

    Article  Google Scholar 

  13. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 33:1444–1452. https://doi.org/10.1212/wnl.33.11.1444

    Article  CAS  Google Scholar 

  14. Krupp LB, LaRocca NG, Muir-Nash J et al (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123. https://doi.org/10.1001/archneur.1989.00520460115022

    Article  CAS  Google Scholar 

  15. Beck AT, Steer RA, Ball R et al (1996) Comparison of beck depression inventories -IA and -II in psychiatric outpatients. J Pers Assess 67:588–597. https://doi.org/10.1207/s15327752jpa6703_13

    Article  CAS  Google Scholar 

  16. Kojima M, Furukawa TA, Takahashi H et al (2002) Cross-cultural validation of the Beck Depression Inventory—II in Japan. Psychiatry Res 110:291–299. https://doi.org/10.1016/s0165-1781(02)00106-3

    Article  Google Scholar 

  17. Chang CH, Cella D, Fernández O et al (2002) Quality of life in multiple sclerosis patients in Spain. Mult Scler 8:527–531. https://doi.org/10.1191/1352458502ms851oa

    Article  CAS  Google Scholar 

  18. Pluta-Fuerst A, Petrovic K, Berger T et al (2011) Patient-reported quality of life in multiple sclerosis differs between cultures and countries: a cross-sectional Austrian-German-Polish study. Mult Scler 17:478–486. https://doi.org/10.1177/1352458510391341

    Article  CAS  Google Scholar 

  19. Pashazadeh Kan F, Hoseinipalangi Z, Ahmadi N et al (2022) Global, regional and national quality of life in patients with multiple sclerosis: a global systematic review and meta-analysis. BMJ Support Palliat Care 12:158–166. https://doi.org/10.1136/bmjspcare-2020-002604

    Article  Google Scholar 

  20. Houzen H, Kondo K, Horiuchi K et al (2018) Consistent increase in the prevalence and female ratio of multiple sclerosis over 15 years in northern Japan. Eur J Neurol 25:334–339. https://doi.org/10.1111/ene.13506

    Article  CAS  Google Scholar 

  21. Piccolo L, Kumar G, Nakashima I et al (2015) Multiple sclerosis in Japan appears to be a milder disease compared to the UK. J Neurol 262:831–836. https://doi.org/10.1007/s00415-015-7637-3

    Article  CAS  Google Scholar 

  22. Acaster S, Swinburn P, Wang C et al (2011) Can the functional assessment of multiple sclerosis adapt to changing needs? A psychometric validation in patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis. Mult Scle 17:1504–1513. https://doi.org/10.1177/1352458511414039

    Article  CAS  Google Scholar 

  23. Sørensen J, Bay J, Damsgaard T et al (2011) Validation of the danish version of functional assessment of multiple sclerosis: a quality of life instrument. Mult Scler Int 2011:121530. https://doi.org/10.1155/2011/121530

    Article  Google Scholar 

  24. Vickrey BG, Hays RD, Harooni R et al (1995) A health-related quality of life measure for multiple sclerosis. Qual Life Res 4:187–206. https://doi.org/10.1007/BF02260859

    Article  CAS  Google Scholar 

  25. Hemmett L, Holmes J, Barnes M et al (2004) What drives quality of life in multiple sclerosis? QJM 97:671–676. https://doi.org/10.1093/qjmed/hch105

    Article  CAS  Google Scholar 

  26. Garg H, Bush S, Gappmaier E (2016) Associations Between Fatigue and Disability, Functional Mobility, Depression, and Quality of Life in People with Multiple Sclerosis. Int J MS Care 18:71–77. https://doi.org/10.7224/1537-2073.2015-013

    Article  Google Scholar 

  27. Fernández-Muñoz JJ, Morón-Verdasco A, Cigarán-Méndez M et al (2015) Disability, quality of life, personality, cognitive and psychological variables associated with fatigue in patients with multiple sclerosis. Acta Neurol Scand 132:118–124. https://doi.org/10.1111/ane.12370

    Article  Google Scholar 

  28. Young CA, Mills R, Rog D et al (2021) Quality of life in multiple sclerosis is dominated by fatigue, disability and self-efficacy. J Neurol Sci 426:117437. https://doi.org/10.1016/j.jns.2021.117437

    Article  Google Scholar 

  29. Oreja-Guevara C, Ayuso Blanco T, Brieva Ruiz L et al (2019) Cognitive dysfunctions and assessments in multiple sclerosis. Front Neurol 10:581. https://doi.org/10.3389/fneur.2019.00581

    Article  Google Scholar 

  30. Reese JP, Wienemann G, John A et al (2013) Preference-based Health status in a German outpatient cohort with multiple sclerosis. Health Qual Life Outcomes 11:162. https://doi.org/10.1186/1477-7525-11-162

    Article  Google Scholar 

  31. Yalachkov Y, Soydaş D, Bergmann J et al (2019) Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis. Mult Scler Relat Disord 30:33–37. https://doi.org/10.1016/j.msard.2019.01.049

    Article  Google Scholar 

  32. Merkelbach S, Sittinger H, Koenig J (2002) Is there a differential impact of fatigue and physical disability on quality of life in multiple sclerosis? J Nerv Ment Dis 190:388–393. https://doi.org/10.1097/00005053-200206000-00007

    Article  Google Scholar 

  33. Ochoa-Morales A, Hernández-Mojica T, Paz-Rodríguez F et al (2019) Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability. Mult Scler Relat Disord 36:101386. https://doi.org/10.1016/j.msard.2019.101386

    Article  CAS  Google Scholar 

Download references

Funding

This work was supported in part by the Health and Labor Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) from the Ministry of Health, Labor, and Welfare of Japan (20FC1030) and the Practical Research Project for Rare/Intractable Diseases of the Japan Agency for Medical Research and Development.

Author information

Authors and Affiliations

Authors

Contributions

MN contributed the conceptualization, methodology, resources, and writing—original draft. SF, TO, NS, HF, MM, TO, HT, YS, JF, IK, JK, ET, and YM contributed the investigation, formal analysis, and writing—review and editing. NM contributed the conceptualization, formal analysis and writing—review and editing. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Masaaki Niino.

Ethics declarations

Conflicts of interest

The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical standards

This study was conducted in accordance with the Declaration of Helsinki, and the study protocol was approved by the ethics committee of each participating site. All participants provided written informed consent to participate in the study.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Niino, M., Fukumoto, S., Okuno, T. et al. Health-related quality of life in Japanese patients with multiple sclerosis. J Neurol 270, 1011–1018 (2023). https://doi.org/10.1007/s00415-022-11453-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-022-11453-9

Keywords

Navigation