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Health-related quality of life in Japanese patients with multiple sclerosis

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Neurological disabilities, especially physical issues, can adversely affect the daily lives of people with multiple sclerosis (MS) and negatively impact their health-related quality of life (HRQOL). On the other hand, physical and psychiatric symptoms are variable in people with MS, and QOL can be influenced by cultural and educational background. This study aimed to evaluate the association of HRQOL with disabilities, fatigue, and depression in Japanese subjects with MS.


Evaluation of HRQOL, fatigue, and depression was performed in 184 Japanese individuals with MS, using the Functional Assessment of MS (FAMS), Fatigue Severity Scale (FSS), and Beck Depression Inventory-Second Edition (BDI-II), respectively.


Multiple linear regression analysis demonstrated negative correlations of the Expanded Disability Status Scale (EDSS) with scores on the FAMS subscales of mobility, symptoms, thinking and fatigue, total FAMS, and additional concerns. The FSS score had negative correlations with mobility, symptoms, emotional well-being, thinking and fatigue, total FAMS, and additional concerns. There were negative correlations between BDI-II scores and all items of FAMS.


HRQOL had relatively close correlations with disabilities and fatigue, and depression had an especially close relationship with HRQOL.

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This work was supported in part by the Health and Labor Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) from the Ministry of Health, Labor, and Welfare of Japan (20FC1030) and the Practical Research Project for Rare/Intractable Diseases of the Japan Agency for Medical Research and Development.

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Authors and Affiliations



MN contributed the conceptualization, methodology, resources, and writing—original draft. SF, TO, NS, HF, MM, TO, HT, YS, JF, IK, JK, ET, and YM contributed the investigation, formal analysis, and writing—review and editing. NM contributed the conceptualization, formal analysis and writing—review and editing. All authors read and approved the final manuscript.

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Correspondence to Masaaki Niino.

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The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical standards

This study was conducted in accordance with the Declaration of Helsinki, and the study protocol was approved by the ethics committee of each participating site. All participants provided written informed consent to participate in the study.

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Niino, M., Fukumoto, S., Okuno, T. et al. Health-related quality of life in Japanese patients with multiple sclerosis. J Neurol 270, 1011–1018 (2023).

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