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Hyperactive vestibular and visually enhanced vestibulo-ocular reflexes in autosomal recessive cerebellar ataxia type 3: a case report

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Funding

Dr. R. Taylor received support from an Aotearoa Fellowship funded through the University of Auckland, Centre for Brain Research, New Zealand. Vestibular test equipment was co-funded by the Eisdell Moore Centre for hearing and balance research and the New Zealand Lottery Grants Board.

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Authors and Affiliations

  1. Centre for Brain Research, Neurogenetics Clinic, University of Auckland, Auckland, New Zealand

    Rachael L. Taylor, Tonci Antunovich, Thomas Ming Hong Chang, Miriam Rodrigues, Ashleigh Baker & Richard H. Roxburgh

  2. Department of Physiology, The University of Auckland, Auckland, New Zealand

    Rachael L. Taylor

  3. Neurology Department, Auckland City Hospital, Auckland, New Zealand

    Miriam Rodrigues, Peter Bergin & Richard H. Roxburgh

  4. Radiology Department, Auckland City Hospital, Auckland, New Zealand

    Ben McGuinness

Authors
  1. Rachael L. Taylor
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  2. Tonci Antunovich
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  3. Thomas Ming Hong Chang
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  4. Miriam Rodrigues
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  5. Ashleigh Baker
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  6. Peter Bergin
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  7. Ben McGuinness
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  8. Richard H. Roxburgh
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Corresponding author

Correspondence to Richard H. Roxburgh.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Written informed consent was obtained from the participant to publish their data.

Supplementary Information

Below is the link to the electronic supplementary material.

ESM. 1 Video recording of VVOR in ARCA3 showing back-up saccades. (MP4 481 KB)

ESM. 2 Video recording of VORS in ARCA3 showing large and frequent back-up saccades consistent with an inability to suppress the VOR using visual fixation (MP4 614 KB)

ESM. 3 Video recording of VVOR in CANVAS showing large catch-up saccades (MP4 998 KB)

ESM. 4 Video recording of VORS in CANVAS showing minimal back-up saccades (MP4 799 KB)

ESM. 5 Video recording of VVOR in a healthy control showing no catch-up saccades (MP4 824 KB)

ESM. 6 Video recording of VORS in a healthy control showing minimal back-up saccades (MP4 718 KB)

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Taylor, R.L., Antunovich, T., Chang, T.M. et al. Hyperactive vestibular and visually enhanced vestibulo-ocular reflexes in autosomal recessive cerebellar ataxia type 3: a case report. J Neurol 270, 1154–1158 (2023). https://doi.org/10.1007/s00415-022-11422-2

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  • DOI: https://doi.org/10.1007/s00415-022-11422-2

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