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Cortical myoclonic tremor after chimeric antigen receptor T-cell therapy

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Fig. 1

source derivation—not shown) demonstrating a weak but significant corticomuscular coherence (middle panel—dashed box) and cortical drive (right panel—dashed box) in a range between 15 and 20 Hz. C Coherence analysis between right Int I/II surface EMG (left panel) and left motor cortex (C3 source derivation—not shown) demonstrating a weak but significant corticomuscular coherence (middle panel—dashed box) and cortical drive (right panel—dashed box) in a band around 20 Hz. D Coherence analysis between right Int I/II surface EMG (left panel) and right motor cortex (C4 source derivation—not shown) demonstrating absence of corticomuscular coherence (middle panel) or cortical drive (right panel). Int I/II first interosseus muscle; Int IV/V, fourth interosseus muscle; ECR extensor carpi radialis muscle; FCR flexor carpi radialis muscle

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Acknowledgements

We are grateful to T. Boeree for generating Fig. 1.

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Authors and Affiliations

  1. Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam UMC, PO Box 22660, 1100DD, Amsterdam, The Netherlands

    Bart E. K. S. Swinnen, Anne-Fleur van Rootselaar, Rob M. A. de Bie, Diederik van de Beek, Matthijs C. Brouwer & Joke M. Dijk

  2. Clinical Neurophysiology, Amsterdam Neuroscience, University of Amsterdam, Amsterdam UMC, PO Box 22660, 1100DD, Amsterdam, The Netherlands

    Anne-Fleur van Rootselaar

  3. Department of Hematology, Cancer Center Amsterdam, Amsterdam, The Netherlands

    Anne M. Spanjaart & Marie J. Kersten

  4. LYMMCARE, Amsterdam, The Netherlands

    Anne M. Spanjaart & Marie J. Kersten

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  1. Bart E. K. S. Swinnen
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Corresponding author

Correspondence to Bart E. K. S. Swinnen.

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Conflicts of interest

MJK has received research funding, compensation for advisory boards and/or presentations and/or travel reimbursement from Kite/Gilead, Novartis, Celgene/BMS and Miltenyi Biotec. The other authors declare no competing interests.

Ethical approval and informed consent

Signed informed consents have been obtained from the patients or their legal representative where applicable. This study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments, and local ethics committee approval was not required as per local regulation.

Supplementary Information

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Supplementary file1 (DOCX 21 KB)

Supplementary file2 Case 1 tremor evaluation. Standardized tremor assessment of case 1 at 97 days post-infusion. 0:00; vowel phonation. 0:07; rest. 0:16; arms outstretched. 0:26; arms flexed at elbows. 0:37; finger-nose-finger. 0:50; legs outstretched & toe-finger. 1:24; spirals—right (dominant). 1:56; line—right (dominant). 2:13; writing. 2:57; spirals—left. 3:31; line—left. 3:52; pointing. 4:04; pouring (MP4 9881 KB)

Supplementary file3 Case 2 tremor evaluation. Standardized tremor assessment of case 2 at 55 days post-infusion. 0:00; vowel phonation. 0:05; rest. 0:11; arms outstretched & stimulus. 0:32; arms flexed at elbows. 0:43; finger-nose-finger. 0:55; legs outstretched. 1:08; toe-finger. 1:19; spirals—right (dominant). 1:43; line—right (dominant). 2:00; writing. 2:18; spirals—left. 2:44; line—left. 3:07; pointing. 3:27; pouring (MP4 8963 KB)

Supplementary file4 Case 3 tremor evaluation. Standardized tremor assessment of case 3 at 40 days post-infusion. 0:00; vowel phonation. 0:04; rest. 0:12; arms outstretched. 0:31; arms flexed at elbows. 0:38; finger-nose-finger. 0:56; legs outstretched. 1:08; toe-finger. 1:18; spirals—left (dominant). 1:45; line—left (dominant). 2:07; writing. 2:34; spirals—right. 3:05; line—left. 3:28; pouring (MP4 9655 KB)

Supplementary file5 Case 4 tremor evaluation. Standardized tremor assessment of case 4 at 21 days post-infusion. 0:00; vowel phonation. 0:04; rest. 0:17; arms outstretched. 0:25; stimulus sensitivity. 0:32; arms flexed at elbows. 0:38; finger-nose-finger. 1:02; legs outstretched & toe-finger. 1:26; spirals—right (dominant). 1:51; line—right (dominant). 2:17; writing. 2:47; spirals—right. 3:05; line—left. 3:23; pointing. 3:45; pouring (MP4 9002 KB)

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Swinnen, B.E.K.S., van Rootselaar, AF., Spanjaart, A.M. et al. Cortical myoclonic tremor after chimeric antigen receptor T-cell therapy. J Neurol 269, 5165–5169 (2022). https://doi.org/10.1007/s00415-022-11127-6

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  • DOI: https://doi.org/10.1007/s00415-022-11127-6

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