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Clinical diagnosis sensitivity of neuropathologically established multiple system atrophy in Japan

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Data availability

The raw data that support the findings of this study are available upon reasonable request from the corresponding author.

References

  1. Ando T, Riku Y, Akagi A, Miyahara H, Hirano M, Ikeda T, Yabata H, Koizumi R, Oba C, Morozumi S, Yasui K, Goto A, Katayama T, Sakakibara S, Aiba I, Sakai M, Konagaya M, Mori K, Ito Y, Yuasa H, Nomura M, Porto KJL, Mitsui J, Tsuji S, Mimuro M, Hashizume Y, Katsuno M, Iwasaki Y, Yoshida M (2022) Multiple system atrophy variant with severe hippocampal pathology. Brain Pathol 32:e13002

    Article  CAS  Google Scholar 

  2. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670–676

    Article  CAS  Google Scholar 

  3. Jellinger KA, Seppi K, Wenning GK (2005) Grading of neuropathology in multiple system atrophy: proposal for a novel scale. Mov Disord 20:S29–S36

    Article  Google Scholar 

  4. Lee YH, Ando T, Lee JJ, Baek MS, Lyoo CH, Kim SJ, Kim M, Cho JW, Sohn YH, Katsuno M, Watanabe H, Yoshida M, Lee PH (2020) Later-onset multiple system atrophy: a multicenter Asian study. Mov Disord 35:1692–1693

    Article  Google Scholar 

  5. Sekiya H, Koga S, Otsuka Y, Chihara N, Ueda T, Sekiguchi K, Yoneda Y, Kageyama Y, Matsumoto R, Dickson DW (2022) Clinical and pathological characteristics of later onset multiple system atrophy. J Neurol. https://doi.org/10.1007/s00415-022-11067-1

    Article  PubMed  Google Scholar 

  6. Trojanowski JQ, Revesz T, Neuropathology Working Grp MSA (2007) Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy. Neuropathol Appl Neurobiol 33:615–620

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to thank all patients and their families as well as clinicians who referred patients to our institute. We also wish to express our gratitude to Kenji Kohtani, Toshiaki Mizuno, Chizuko Sano, and Chieko Uno for their technical support.

Funding

MY was supported by a grant from Intramural Research Grant (30-8) for Neurological and Psychiatric Disorders of NCNP. YR was supported by a grant from JSPS KAKENHI (no. JP20K16586). YI was supported by Grants-in-Aid from the Research Committee of CNS Degenerative Diseases; Research on Policy Planning and Evaluation for Rare and Intractable Diseases; Health, Labour, and Welfare Sciences Research Grants; and the Ministry of Health, Labour, and Welfare, Japan. This research was partly supported by AMED under Grant Number JP21wm0425019 (MY).

Author information

Authors and Affiliations

  1. Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan

    Takashi Ando, Yuichi Riku & Masahisa Katsuno

  2. Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan

    Takashi Ando, Yuichi Riku, Akio Akagi, Hiroaki Miyahara, Jun Sone, Mari Yoshida & Yasushi Iwasaki

  3. Department of Clinical Research Education, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan

    Masahisa Katsuno

Authors
  1. Takashi Ando
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  2. Yuichi Riku
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  3. Akio Akagi
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  4. Hiroaki Miyahara
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  5. Jun Sone
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  6. Masahisa Katsuno
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  7. Mari Yoshida
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  8. Yasushi Iwasaki
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Contributions

Conceptualization: TA; methodology: TA, YR, and MY; investigation: TA, YR, AA, HM, JS, MY, and YI; writing, original draft: TA; writing, review, and editing: YR, MK, MY, and YI; supervision: MK, MY, and YI.

Corresponding author

Correspondence to Takashi Ando.

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Conflicts of interest

The authors report no competing interests.

Ethical approval

Written informed consent was obtained from the patients’ relatives before autopsies. All human studies were approved by the research ethics committee of the Aichi Medical University.

Supplementary Information

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Supplementary file1 (DOCX 232 KB)

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Ando, T., Riku, Y., Akagi, A. et al. Clinical diagnosis sensitivity of neuropathologically established multiple system atrophy in Japan. J Neurol 269, 5162–5164 (2022). https://doi.org/10.1007/s00415-022-11122-x

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  • DOI: https://doi.org/10.1007/s00415-022-11122-x

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