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Neurologic manifestations of giant cell arteritis

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Abstract

Giant cell arteritis, the most frequent form of vasculitis in persons over 50 years of age, is a granulomatous chronic vasculitis involving large and medium-sized vessels, most commonly the temporal and other cranial arteries. This common, treatable condition is associated with various clinical symptoms, including neurological ones, affecting both the central and peripheral nervous systems. In this review, we discuss the cranial and extra cranial neurological complications of giant cell arteritis, to help avoid the many pitfalls in the diagnosis of giant cell arteritis.

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Abbreviations

3D:

Three dimension

ACR:

American College of Rheumatology

C:

Cervical nerve root

CIDP:

Chronic inflammatory demyelinating polyradiculoneuropathy

CK:

Creatine kinase

CT:

Computerized tomography

EMG:

Electromyography

ESR:

Erythrocyte sedimentation rate

EULAR:

European league against rheumatism

18FDG-PET:

18Fluorodeoxyglucose positron emission tomography

GCA:

Giant cell arteritis

LLV:

Large vessel vasculitis

MRI:

Magnetic resonance imaging

NB:

Nerve biopsy

PC:

Platelet count

PET:

Positron emission tomography

PMR:

Polymyalgia rheumatic

PNS:

Peripheral nervous system

TAB:

Temporal artery biopsy

Th:

Thoracic nerve root

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Authors and Affiliations

  1. Department of Neurology, Competence Center for Neuromuscular Diseases, ‘Côte Basque’ Hospital (CH Bayonne), 13 Av. de l’Interne Jacques Loeb, 64100, Bayonne, France

    Antoine Soulages, Emmanuel Ellie & Frédéric Bourdain

  2. Department of Neurology (Stroke Unit), University Hospital of Bordeaux (CHU Bordeaux), Pellegrin Hospital, 1 place Amélie Raba-Léon, 33076, Bordeaux, France

    Igor Sibon

  3. Department and Laboratory of Neurology, National Reference Center for ‘Rare Peripheral Neuropathies’, University Hospital of Limoges (CHU Limoges), Dupuytren Hospital, 2 avenue Martin Luther King, 87042, Limoges, France

    Jean-Michel Vallat

  4. Department of Neurology (Nerve-Muscle Unit), AOC National Reference Center for Neuromuscular Disorders, ALS Center, University Hospital of Bordeaux (CHU Bordeaux), Pellegrin Hospital, 1 place Amélie Raba-Léon, 33076, Bordeaux, France

    Fanny Duval, Louis Carla, Guilhem Solé, Gwendal Le Masson & Stéphane Mathis

  5. Department of Pathology, University Hospital of Bordeaux (CHU Bordeaux), Pellegrin Hospital, 1 place Amélie Raba-Léon, 33076, Bordeaux, France

    Marie-Laure Martin-Négrier

  6. Department of Radiology, ‘Côte Basque’ Hospital (CH Bayonne), 13 Av. de l’Interne Jacques Loeb, 64100, Bayonne, France

    Charles Laurent

  7. Department of Rheumatology, ‘Côte Basque’ Hospital (CH Bayonne), 13 Av. de l’Interne Jacques Loeb, 64100, Bayonne, France

    Agnès Monnier

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  1. Antoine Soulages
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  7. Louis Carla
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  8. Marie-Laure Martin-Négrier
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  12. Gwendal Le Masson
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  13. Stéphane Mathis
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Correspondence to Stéphane Mathis.

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Soulages, A., Sibon, I., Vallat, JM. et al. Neurologic manifestations of giant cell arteritis. J Neurol 269, 3430–3442 (2022). https://doi.org/10.1007/s00415-022-10991-6

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  • DOI: https://doi.org/10.1007/s00415-022-10991-6

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