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Brain hyper-excitability in DPPX ataxia

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Acknowledgements

The authors would like to thank Dr Patrick Waters for his work in setting up the DPPX assay. This is a summary of independent research carried out at the NIHR Sheffield Biomedical Research Centre (Translational Neuroscience). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

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None.

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Authors and Affiliations

  1. Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK

    M. Pattrick, P. G. Sarrigiannis, Z. Unwin, P. Zis, D. J. Blackburn & Marios Hadjivassiliou

  2. Department of Neuroradiology, Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Sheffield, UK

    N. Hoggard

  3. Department of Psychiatry, Doncaster, UK

    S. Kruger

  4. Department of Neurorehabilitation, Doncaster and South, Humber NHS Trust, Doncaster, UK

    B. Davies

  5. Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

    S. R. Irani

Authors
  1. M. Pattrick
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  2. P. G. Sarrigiannis
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  3. S. Kruger
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  4. B. Davies
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  5. N. Hoggard
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  6. S. R. Irani
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  7. Z. Unwin
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  8. P. Zis
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  9. D. J. Blackburn
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  10. Marios Hadjivassiliou
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Corresponding author

Correspondence to Marios Hadjivassiliou.

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Conflicts of interest

The authors have no conflicts of interest to disclose.

Ethical standards

This article summarizes observational case series of 3 patients with DPPX-ARA being managed at the Sheffield Ataxia Centre (SAC), Sheffield UK. The South Yorkshire Research Ethics Committee has confirmed that no ethical approval is indicated given that immunosuppression is a recognized treatment for DPPX-ARA and that all investigations/interventions were clinically indicated and did not form part of a research study.

Data access, responsibility and analysis

The corresponding author had full access to all the data and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Pattrick, M., Sarrigiannis, P.G., Kruger, S. et al. Brain hyper-excitability in DPPX ataxia. J Neurol 267, 3096–3099 (2020). https://doi.org/10.1007/s00415-020-10182-1

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  • DOI: https://doi.org/10.1007/s00415-020-10182-1

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