Efficacy and safety of galcanezumab for preventive treatment of migraine: a systematic review and meta-analysis



This meta-analysis aimed to systematically evaluate the effectiveness and safety of galcanezumab in the prophylactic treatment of adult migraine.


A systematic literature search was performed to identity randomized-controlled trials (RCTs). The primary outcome was the decline in the number of monthly migraine days (MMDs). Secondary outcomes included the reduction of monthly acute migraine‑specific medication days (MSMDs), the number of participants showing a reduction in MMDs from baseline of ≥ 50%, ≥ 75%, and 100%, the incidence of adverse events (AEs), and the number of participants developing anti-drug antibodies (ADAs) to galcanezumab. We calculated the mean difference (MD), relative risk (RR), and 95% confidence intervals (CIs) for these outcomes.


Among the five included trials, galcanezumab given at doses of 120, 150, 240, and 300 mg was superior to placebo for both MMDs and secondary outcomes. The degree of AEs in all group was mild. Notably, no significant differences were found in the occurrence of AEs and ADAs between the galcanezumab and placebo groups.


Galcanezumab is a safe and effective treatment for adult patients with episodic and chronic migraine.


Migraine is a common primary headache disorder that has been regarded as one of the most disabling disorders affecting millions of people worldwide. Headaches manifest as pain of varying intensity characterized by repeated, moderate, or severe, unilateral, or bilateral pulsating headaches lasting for hours and possibly days often combined with autonomic dysfunctions such as nausea, vomiting, photophobia, and phobia. Some patients also experience prodromal and/or postdromal phase-like symptoms. Headaches persisting for 15 days or more (over 3 months for 8 consecutive days in a month) are considered as chronic migraines [1]. According to statistics, in 2016, nearly 1.04 billion individuals suffered from migraine. By 2016, migraine accounted for 45.1 million years of life lived with disability (YLDs), representing an increase of 51.2% from 29.8 million YLDs in 1990 [2]. Chronic migraine is the major cause of more severe headache-related disability, when compared to episodic migraine, although it affects merely 1–3% of the worldwide population [3,4,5]. Patients with migraines have higher expenditures on outpatient, emergency, and prescription drug than those without this disorder [6]. Individuals with chronic migraine have to bear greater headache-related direct, indirect, and total costs [7].

The etiology and pathogenesis of migraine remains incompletely understood. However, some neurotransmitters and vasoactive substances, such as nitric oxide (NO), serotonin (5-hydroxytryptamine; 5-HT), and calcitonin gene-related peptide (CGRP), have been identified to be implicated in the initiation of migraine. The 5-HT receptor agonists, e.g., ergotamine and triptans, and CGRP receptor antagonists have been proven to be effective for the treatment of migraine attacks [1, 8]. However, these drugs can cause medication overuse headache, hepatotoxicity, and cardiovascular and central side effects [9]. A survey revealed that more than 70% of patients using these drugs stopped or switched treatment due to drug side effects and intolerance. While so far, monoclonal antibodies against CGRP were almost devoid of serious adverse reactions [9, 10].

Thus, anti-CGRP monoclonal antibodies are used as the prophylactic treatments for migraine. Galcanezumab was authorized in the USA in May 2018. In this meta-analysis, we collected and analyzed RCTs of galcanezumab in the prevention of migraine in adults. The results of this analysis are expected to provide evidence-based date for prophylactic managements of migraine.


Search strategy

This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched for relevant RCTs on the PubMed, the Cochrane Library, Web of Science, and Clinicaltrail.gov using the following keywords: migraine and galcanezumab or LY2951742. The last search date was March 3, 2019. During the search, two authors independently read the whole articles and inspected the reference lists. Any divergence was resolved by discussion between the authors.

Inclusion and exclusion criteria

We included articles that met the following criteria: (1) the study was a randomized-controlled trial (RCT) on calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) for migraine prophylaxis; (2) the patients were diagnosed with migraine according to the International Classification of Headache Disorders, third edition (ICHD-3, beta version) or the International Classification of Headache Disorders (ICHD-II); (3) no limitations on the time of publication, and blind or publication types. Studies were excluded when one of the following situations occurred: (1) the subjects were non-adults with migraine; (2) the CGRP-mAbs were administered as adjuvant drugs; and (3) studies were not RCTs.

Data extraction

Two investigators independently assessed the selected studies and extracted the following information: main author, completion date, study design (methods of randomization, allocation and blinding, type of migraine, dose of intervention, route of administration, frequency of injection and course of treatment), basic information of the research objects (number of participants, age range of participants, number of the males and females, and baseline characteristics), inclusion and exclusion criteria, primary and secondary outcome measures, and adverse events. This metanalysis conformed to the principles of the Cochrane Handbook for Systematic Reviews of Interventions. Any discrepancies in the results were resolved through consensus between investigators.

Data analysis

Since the extent of heterogeneity may affect the results and conclusions of a meta-analysis, the Chi-square test was used to assess the statistical heterogeneity. It was suitable to use the fixed-effect model to analyze whether I2 < 50%, which meant that there was no significant heterogeneity. Otherwise, heterogeneity was regarded as unacceptable, and a random-effects model or subgroup analysis was considered. Publication bias was determined using funnel plots. Continuous outcomes were analyzed using mean differences (MD) and 95% confidence intervals (CIs), while dichotomous outcomes were analyzed using relative risk (RR) and 95% CIs. P < 0.05 was regarded as statistically significant. All data analyses were performed using Review Manager 5.3.


Selection and characteristics of studies

A total of 389 compositions were identified in the preliminary search. Among them, five studies were adopted in the analysis. The other studies were excluded for various reasons. Details of the screening procedure are presented in Fig. 1. All included studies were two-phase II and three-phase III trials, and were multicenter, randomized, double-blinded and placebo-controlled trials. The included trails covered a total of 3565 patients with episodic or chronic migraine. Different doses of galcanezumab were reported: 5, 50, 120, 150, 240, and 300 mg. The baseline characteristics of these studies and participants are summarized in Tables 1 and 2.

Fig. 1

Flow diagram of the literature selection process

Table 1 Main characteristics of the enrolled studies
Table 2 Main characteristics of the participants

Risk of bias

Bias were assessed according to the Cochrane Handbook of Systematic Review. The details are presented in Figs. 2 and 3. All participants in the five studies were randomly assigned to groups via a computer-generated random sequence with an interactive web-response system. One trial reported that the pharmacists were unmasked, but they did not participate in any other aspect of the study other than the preparation and inventory of drugs. Another trial did not expound the allocation concealment and blinding of the outcome assessment. All five trials recorded the loss of follow-up of patients. Furthermore, each pre-defined outcome was explained. All trials that met the inclusion criteria were enrolled in this meta-analysis.

Fig. 2

Risk of bias for the included trials

Fig. 3

Risk of bias summary for the included trials

Efficacy evaluation

Monthly migraine days (MMDs) and monthly acute migraine-specific medication days (MSMDs)

Subgroup analysis performed with regard to the dose demonstrated that galcanezumab at 120, 150, 240, and 300 mg significantly reduced MMDs (120 mg: MD − 1.79, 95% CI − 2.06 to − 1.53, P < 0.00001; 150 mg: MD − 1.20, 95% CI − 1.28 to − 1.12, P < 0.00001; 240 mg: MD − 1.85, 95% CI − 1.94 to − 1.76, P < 0.0001; 300 mg: MD − 0.62, 95% CI − 0.73 to − 0.51, P < 0.00001; Fig. 4). There was notable heterogeneity in the overall results (P < 0.00001, I2 = 100%), while by removing any single hazard ratio from the meta-analysis, the sensitivity analysis did not substantively alter the overall result. The inverse funnel plot, which evaluated the risk of publication bias, was approximately symmetrical indicating no significant publication bias in the results (Fig. 5a). Studies in our meta-analysis also revealed that the reduction in MSMDs for galcanezumab of 120 and 240 mg vs. placebo was at a statistically significant level.

Fig. 4

Change from baseline in MMDs. MD mean difference, CI confidence interval

Fig. 5

a Funnel plot 1. Funnel plot of the reduction in MMDs, b Funnel plot 2. Funnel plot for the 50%, 75% and 100% responder rates of the reduction from baseline in MMDs, c Funnel plot 3. Funnel plot of adverse events

The 50%, 75%, and 100% responder rate

Compared to the placebo group, patients in the galcanezumab group were more likely to represent a significant increase of 50%, 75%, and 100% in responder rates of the reduction from baseline in MMDs (50%: RR 1.50, 95% CI 1.36–1.65, P = 0.20; 75%: RR 1.88, 95% CI 1.64–2.16, P = 0.78; 100%: RR 1.95, 95% CI 1.56–2.44, P = 0.58; Fig. 6). However, the meta-analysis revealed a non-significant heterogeneity among the included trials (P = 0.07, I2 = 39%). The inverse funnel plot (Fig. 5b) presented a low level of publication bias.

Functional measurement

The phase II study of galcanezumab assessed the migraine-specific quality of life using the Migraine-Specific Quality of Life (MSQL) questionnaire and the Headache Impact Test™ (HIT-6). However, those data were not underwent formal statistical analyses. At the phase IIb study, Vladimir Skljarevski et al. conducted a post hoc secondary analyses with the same questionnaires. The results demonstrated that the change in MHD was concerned with the improvements in MSQL and the decline in HIT-6 scores. In the phase III studies, the investigators mainly focused on the change in Migraine-Specific Quality of Life questionnaire role function restrictive domain (MSQ RFR). It was found that both doses of galcanezumab led to a greater improvement in scores, when compared to placebo, i.e., the treatment with galcanezumab was associated with the reduction in functional impairment [11].

Adverse events

A total of 2998 patients in all trials reported adverse events to different degrees. The total adverse events observed in patients with galcanezumab were not significantly different from those that occurred in the placebo groups, based on the meta-analysis (RR 0.91, 95% CI 0.86–0.96, P = 0.82; Fig. 7). Furthermore, there were no significant heterogeneity (P = 0.82, I2 = 0%) and no obvious publication bias in the results, which are presented in Fig. 5c. These findings suggest that galcanezumab is safe for migraine prophylaxis.

Fig. 6

The ≥ 50% reduction change from baseline in MMDs. RR risk ratio, CI confidence interval

Fig. 7

Adverse events for galcanezumab. RR risk ratio, CI confidence interval

Fig. 8

The development of anti-drug antibodies (ADA) to galcanezumab. RR risk ratio, CI confidence interval

The most frequently reported treatment-emergent adverse events (TEAEs) was injection-site pain. Otherwise, the results of the REGAIN, EVOLVE-1, and EVOLVE-2 trials revealed injection-site reactions, injection-site erythema, injection-site pruritus, and injection-site swelling at a greater rate in one or both treatment groups, when compared to placebo group. The other AEs were presented in Table 3. All studies reported serious adverse reactions (SAE), but none of these SAEs occurred in more than one patient. Therefore, no SAEs was induced by the study drug. Furthermore, there were no clinical meaningful changes in vital signs, ECGs, or laboratory parameters between galcanezumab and placebo. According to David W Dodick, it was only stated that 20 patients were detected with anti-drug antibodies (ADAs) at the end of the study, but the study did not clearly describe the antibody status in each group. Other ADA details are presented in Fig. 8 (Total: RR 2.89, 95% CI 1.74–4.80, P < 0.0001, I2 = 37%).

Table 3 Major adverse events (includes treatment-emergent adverse events)


Effectiveness of galcanezumab

The meta-analysis evaluated the efficacy and safety of galcanezumab for the treatment of migraine. In this part of the analysis, 5258 patients were included. Monthly migraine days, headache hours, and the number of monthly migraine days that required acute treatment were all significantly lower than those from baseline. Furthermore, the ≥ 50%, ≥ 75%, or 100% response was greater in the galcanezumab group, when compared to placebo [12,13,14,15,16,17]. Further research should be performed for patients with 100% or no treatment response to identify predictors. Unilateral pain, unilateral autonomic symptoms, or allodynia have been considered as possible markers for those extremely good responders, but their predictive value still needs to be further confirmed [18].

The response in galcanezumab-treated patients could last for more consecutive months [19]. Efficacy even continued to exist during the post-treatment periods. Given the results from the randomized phase III trials, the therapeutic effect of galcanezumab was reduced after therapeutic treatment as a whole, but MMDs did not return to baseline [20, 21]. Galcanezumab not only lasted for a long time, but also had a rapid onset of action. According to the post hoc analysis of phase II-a study, the significant change in migraine headache days initiated an onset in the first week. Nearly half of the responses happened in the first month [22]. According to the EVOLVE studies’ subgroup analysis, the drug (galcanezumab) took effect a day after injection. It might be explained by pharmacokinetic characteristics of galcanezumab that an average time to its peak serum concentration was 5 days. Otherwise, double administration of the first dose helped to speed up the onset of the effects as well, since the therapeutic steady-state concentration of galcanezumab might be achieved after the first injection [23, 24]. Even if there was no notable initial effect, more patients would be relieved of headache through continuous administration [25].

Galcanezumab had effectiveness on individuals with failed preventions too. Differences in outcomes between galcanezumab and placebo were larger in the prior preventive failure subgroups based on the EVOLVE studies. It appeared to be driven by the lower placebo response in patients with prior failure [26]. The same conclusion was drawn from another post hoc analyses of 3 phase III studies, in which galcanezumab was provided as following treatment after failure to onabotulinumtoxinA. It's worth noting that our analyses did not compare the efficacy of galcanezumab to onabotA [27]. The data of head-to-head trials compared galcanezumab to oral preventatives are limited currently.

All results suggest that galcanezumab is effective for the prevention of migraine, but it is noteworthy that a high level of heterogeneity was found in the efficacy analysis. This may be because studies in the meta-analysis contained both episodic and chronic migraine population. Furthermore, the basic characteristics of each participant also more or less varied. However, these did not affect the conclusion.

The open-label phase study of REGAIN revealed that treatment with galcanezumab is likely to lead to high satisfaction with a therapeutic effect, together with meaningful reductions in health care resource utilization and acute headache medication [28]. This confirms that galcanezumab effectively improves the quality of life of migraine participants through direct or indirect contribution. The efficacy of galcanezumab was equal between those with high-frequency episodic migraine and those with low-frequency episodic migraine [29]. These above results are applicable to chronic migraine patients, whose previous migraine preventive treatments all failed [30].

Safety of galcanezumab

The safety of galcanezumab was proven through minimal changes from baseline in vital signs, ECGs, and laboratory parameters. Among the phase II and III trials, no apparent differences in frequency and type of TEAEs were exposed between the galcanezumab dose groups and placebo group, except for EVOLVE-2, in which the galcanezumab 240 mg group exhibited a larger proportion of patients that referred at least one TEAE. Most of the TEAEs were transient, and mild or moderate in severity, without any obvious relationship with prolonged drug exposure, which was likely to be due to the long half-life of the Ab [31]. In addition to the studies included in the present meta-analysis, a phase III, long-term open-label study was performed to evaluate the safety and tolerability of galcanezumab. The findings supported those safety analyses in the other five previous studies [32].

Since CGRP can cause vasodilation, vascular adverse reactions deserve special attention. In the galcanezumab 240 mg group of EVOLVE-2, seven patients suffered from acute myocardial infarction and transient ischemic attack [15]. Meanwhile, hypertension was observed in five patients in the clinical trials, but it remains uncertain if these patients had hypertension before enrollment [33]. Although the results of these trials revealed that the administration of galcanezumab was not associated with a time- or dose-related cardiovascular events, it is necessary to verify these through long-term large-sample-size studies. On the other hand, it is a lack of evidence that galcanezumab was safe in those with known cardiovascular disease. Patients with acute or serious cardiovascular risks were excluded on account of the inclusion/exclusion criteria [34]. Galcanezumab exhibited low hepatotoxicity and nephrotoxicity in all test data which was probably because majority of the antibodies were eliminated via intracellular catabolism into the peptides and amino acids by endocytosis. However, the large volume of antibodies prevented these to be effectively filtered through the glomerulus [23].

Another concern for the safety of galcanezumab in these studies was treatment-emergent ADAs and neutralizing ADAs, which can increase or decrease the clearance of galcanezumab, or inhibit the ligand binding to it. Accordingly, the emergence of ADAs is correlated with possible allergic drug reactions, low efficacy, and AEs. Fortunately, studies revealed no impact on either safety or efficacy of galcanezumab by ADAs [31]. However, it should be noted that the immunogenicity results are highly dependent on the assay methodology, and this may be misleading on the comparison of the incidence of ADA across studies [23].

Limitations of the meta-analysis

The present review also has some limitations. First, the present study was restricted to eligibility criteria, in which merely five studies were included in the analysis. Some unpublished and missing data of studies might also influence aggregate results. Furthermore, some of the studies were completed by the same researchers, which may lead to publication bias. In addition, the double-blind period of these present included studies ranged from 3 to 6 months, and the difference might result in heterogeneity. Finally, due to the exclusion of patients older than 65 years old, gravidas, or patients with a history of major cardiovascular or cerebrovascular diseases, the results of the systematic review lack universality.

Furthermore, studies with longer follow-ups and larger samples sizes should be performed to identify the confirmative safety profile of galcanezumab, and determine the duration of its therapeutic effects.


The present meta-analysis systematically reveals that galcanezumab is superior to placebo for migraine, in terms of efficacy, safety, and tolerability. Indeed, these finding needs further investigations to identify the causes of the statistical heterogeneity among studies. However, overall, galcanezumab is a safe and well-tolerated pharmaceutical reagent that can be offered to migraine patients.


  1. 1.

    Olesen J, Bendtsen L, Goadsby P, Wang S-J, Schwedt T, Ducros A, Dodick DW, Russell MB, Tassorelli C, Pascual J, Levin M, Vincent M, Katsarava Z, Germany and T Nurmikko et al (2018) Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38(1):1–211. https://doi.org/10.1177/0333102417738202

  2. 2.

    Stovner LJ, Nichols E, Steiner TJ, Abd-Allah F, Abdelalim A, Al-Raddadi RM, Ansha MG, Barac A, Bensenor IM, Doan LP, Edessa D, Endres M, Foreman KJ, Gankpe FG, Gopalkrishna G, Goulart AC, Gupta R, Hankey GJ, Hay SI, Hegazy MI, Hilawe EH, Kasaeian A, Kassa DH, Khalil I, Khang YH et al (2018) Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2018). Lancet Neurol 17(11):954–976. https://doi.org/10.1016/s1474-4422(18)30322-3

    Article  Google Scholar 

  3. 3.

    Lipton RB, Manack Adams A, Buse DC, Fanning KM, Reed ML (2016) A comparison of the chronic migraine epidemiology and outcomes (CaMEO) study and American migraine prevalence and prevention (AMPP) study: demographics and headache-related disability. Headache 56(8):1280–1289. https://doi.org/10.1111/head.12878

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Buse DC, Manack AN, Fanning KM, Serrano D, Reed ML, Turkel CC, Lipton RB (2012) Chronic migraine prevalence, disability, and sociodemographic factors: results from the American Migraine Prevalence and Prevention Study. Headache 52(10):1456–1470. https://doi.org/10.1111/j.1526-4610.2012.02223.x

    Article  PubMed  Google Scholar 

  5. 5.

    Buse D, Manack A, Serrano D, Reed M, Varon S, Turkel C, Lipton R (2012) Headache impact of chronic and episodic migraine: results from the American migraine prevalence and prevention study. Headache 52(1):3–17. https://doi.org/10.1111/j.1526-4610.2011.02046.x

    Article  PubMed  Google Scholar 

  6. 6.

    Raval AD, Shah A (2017) National trends in direct health care expenditures among US adults with migraine: 2004 to 2013. The J Pain 18(1):96–107. https://doi.org/10.1016/j.jpain.2016.10.005

    Article  PubMed  Google Scholar 

  7. 7.

    Messali A, Sanderson JC, Blumenfeld AM, Goadsby PJ, Buse DC, Varon SF, Stokes M, Lipton RB (2016) Direct and indirect costs of chronic and episodic migraine in the US: a web-based survey. Headache 56(2):306–322. https://doi.org/10.1111/head.12755

    Article  PubMed  Google Scholar 

  8. 8.

    Hou M, Xing H, Cai Y, Li B, Wang X, Li P, Hu X, Chen J (2017) The effect and safety of monoclonal antibodies to calcitonin gene-related peptide and its receptor on migraine: a systematic review and meta-analysis. J Headache pain 18(1):42. https://doi.org/10.1186/s10194-017-0750-1

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Gonzalez-Hernandez A, Marichal-Cancino BA, MaassenVanDenBrink A, Villalon CM (2018) Side effects associated with current and prospective antimigraine pharmacotherapies. Expert Opin Drug Metab Toxicol 14(1):25–41. https://doi.org/10.1080/17425255.2018.1416097

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Ford JH, Jackson J, Milligan G, Cotton S, Ahl J, Aurora SK (2017) A real-world analysis of migraine: a cross-sectional study of disease burden and treatment patterns. Headache 57(10):1532–1544. https://doi.org/10.1111/head.13202

    Article  PubMed  Google Scholar 

  11. 11.

    Ford JH, Ayer DW, Zhang Q, Carter JN, Leroux E, Skljarevski V, Aurora SK, Tockhorn-Heidenreich A, Lipton RB (2019) Two randomized migraine studies of galcanezumab: Effects on patient functioning and disability. Neurology 93(5):e508–e517. https://doi.org/10.1212/wnl.0000000000007856

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Dodick DW, Goadsby PJ, Spierings EL, Scherer JC, Sweeney SP, Grayzel DS (2014) Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Neurol 13(9):885–892. https://doi.org/10.1016/s1474-4422(14)70128-0

    CAS  Article  PubMed  Google Scholar 

  13. 13.

    Skljarevski V, Oakes TM, Zhang Q, Ferguson MB, Martinez J, Camporeale A, Johnson KW, Shan Q, Carter J, Schacht A, Goadsby PJ, Dodick DW (2018) Effect of different doses of galcanezumab vs placebo for episodic migraine prevention: a randomized clinical trial. JAMA Neurol 75(2):187–193. https://doi.org/10.1001/jamaneurol.2017.3859

    Article  PubMed  Google Scholar 

  14. 14.

    Stauffer VL, Dodick DW, Zhang Q, Carter JN, Ailani J, Conley RR (2018) Evaluation of galcanezumab for the prevention of episodic migraine: the EVOLVE-1 randomized clinical trial. JAMA Neurol 75(9):1080–1088. https://doi.org/10.1001/jamaneurol.2018.1212

    Article  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Skljarevski V, Matharu M, Millen BA, Ossipov MH, Kim BK, Yang JY (2018) Efficacy and safety of galcanezumab for the prevention of episodic migraine: results of the EVOLVE-2 phase 3 randomized controlled clinical trial. Cephalalgia 38(8):1442–1454. https://doi.org/10.1177/0333102418779543

    Article  PubMed  Google Scholar 

  16. 16.

    Detke HC, Goadsby PJ, Wang S, Friedman DI, Selzler KJ, Aurora SK (2018) Galcanezumab in chronic migraine: the randomized, double-blind, placebo-controlled REGAIN study. Neurology 91(24):e2211–e2221. https://doi.org/10.1212/wnl.0000000000006640

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  17. 17.

    Rosen N, Pearlman E, Ruff D, Day K, Jim Nagy A (2018) 100% Response rate to galcanezumab in patients with episodic migraine: a post hoc analysis of the results from phase 3, randomized, double-blind, placebo-controlled EVOLVE-1 and EVOLVE-2 studies. Headache 58(9):1347–1357. https://doi.org/10.1111/head.13427

    Article  PubMed  PubMed Central  Google Scholar 

  18. 18.

    Raffaelli B, Neeb L, Reuter U (2019) Monoclonal antibodies for the prevention of migraine. Expert Opin Biol Ther 19(12):1307–1317. https://doi.org/10.1080/14712598.2019.1671350

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Forderreuther S, Zhang Q, Stauffer VL, Aurora SK, Lainez MJA (2018) Preventive effects of galcanezumab in adult patients with episodic or chronic migraine are persistent: data from the phase 3, randomized, double-blind, placebo-controlled EVOLVE-1, EVOLVE-2, and REGAIN studies. J Headache Pain 19(1):121. https://doi.org/10.1186/s10194-018-0951-2

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  20. 20.

    Stauffer VL, Wang S, Voulgaropoulos M, Skljarevski V, Kovacik A, Aurora SK (2019) Effect of galcanezumab following treatment cessation in patients with migraine: results from 2 randomized phase 3 trials. Headache 59(6):834–847. https://doi.org/10.1111/head.13508

    Article  PubMed  PubMed Central  Google Scholar 

  21. 21.

    Raffaelli B, Mussetto V, Israel H, Neeb L, Reuter U (2019) Erenumab and galcanezumab in chronic migraine prevention: effects after treatment termination. J Headache Pain 20(1):66. https://doi.org/10.1186/s10194-019-1018-8

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Goadsby PJ, Dodick DW, Martinez JM, Ferguson MB, Oakes TM, Zhang Q, Skljarevski V, Aurora SK (2019) Onset of efficacy and duration of response of galcanezumab for the prevention of episodic migraine: a post-hoc analysis. J Neurol Neurosurg Psychiatry 90(8):939–944. https://doi.org/10.1136/jnnp-2018-320242

    Article  PubMed  PubMed Central  Google Scholar 

  23. 23.

    Kielbasa W, Helton DL (2019) A new era for migraine: Pharmacokinetic and pharmacodynamic insights into monoclonal antibodies with a focus on galcanezumab, an anti-CGRP antibody. Cephalalgia 39(10):1284–1297. https://doi.org/10.1177/0333102419840780

    Article  PubMed  PubMed Central  Google Scholar 

  24. 24.

    Detke HC, Millen BA, Zhang Q, Samaan K, Ailani J, Dodick DW, Aurora SK (2019) Rapid onset of effect of galcanezumab for the prevention of episodic migraine: analysis of the EVOLVE studies. Headache. https://doi.org/10.1111/head.13691

    Article  PubMed  Google Scholar 

  25. 25.

    Nichols R, Doty E, Sacco S, Ruff D, Pearlman E, Aurora SK (2019) Analysis of initial nonresponders to galcanezumab in patients with episodic or chronic migraine: results from the EVOLVE-1, EVOLVE-2, and REGAIN randomized, double-blind placebo controlled studies. Headache 59(2):192–204. https://doi.org/10.1111/head.13443

    Article  PubMed  Google Scholar 

  26. 26.

    Ruff DD, Ford JH, Tockhorn-Heidenreich A, Stauffer VL, Govindan S, Aurora SK, Terwindt GM, Goadsby PJ (2019) Efficacy of galcanezumab in patients with episodic migraine and a history of preventive treatment failure: results from two global randomized clinical trials. Eur J Neurol. https://doi.org/10.1111/ene.14114

    Article  PubMed  Google Scholar 

  27. 27.

    Ailani J, Pearlman E, Zhang Q, Nagy AJ, Schuh K, Aurora SK (2019) Positive response to galcanezumab following treatment failure to onabotulinumtoxin A in patients with migraine: post hoc analyses of three randomized double-blind studies. Eur J Neurol. https://doi.org/10.1111/ene.14102

    Article  PubMed  Google Scholar 

  28. 28.

    Ford JH, Foster SA, Stauffer VL, Ruff DD, Aurora SK, Versijpt J (2018) Patient satisfaction, health care resource utilization, and acute headache medication use with galcanezumab: results from a 12-month open-label study in patients with migraine. Patient Prefer Adher 12:2413–2424. https://doi.org/10.2147/ppa.s182563

    Article  Google Scholar 

  29. 29.

    Silberstein SD, Stauffer VL, Day KA, Lipsius S, Wilson MC (2019) Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2). J Headache pain 20(1):75. https://doi.org/10.1186/s10194-019-1024-x

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  30. 30.

    Ruff DD, Ford JH, Tockhorn-Heidenreich A, Sexson M, Govindan S, Pearlman EM, Wang SJ, Khan A, Aurora SK (2019) Efficacy of galcanezumab in patients with chronic migraine and a history of preventive treatment failure. Cephalalgia 39(8):931–944. https://doi.org/10.1177/0333102419847957

    Article  PubMed  Google Scholar 

  31. 31.

    Lupi C, Guerzoni S, Negro A, Benemei S (2019) Once-monthly galcanezumab for the prevention of migraine in adults: an evidence-based descriptive review and potential place in therapy. Ther Clin Risk Manag 15:557–569. https://doi.org/10.2147/tcrm.s159690

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  32. 32.

    Camporeale A, Kudrow D, Sides R, Wang S, Van Dycke A, Selzler KJ, Stauffer VL (2018) A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine. BMC Neurol 18(1):188. https://doi.org/10.1186/s12883-018-1193-2

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  33. 33.

    Khan S, Olesen A, Ashina M (2019) CGRP, a target for preventive therapy in migraine and cluster headache: systematic review of clinical data. Cephalalgia 39(3):374–389. https://doi.org/10.1177/0333102417741297

    Article  PubMed  Google Scholar 

  34. 34.

    Oakes TM, Kovacs R, Rosen N, Doty E, Kemmer P, Aurora SK, Camporeale A (2019) Evaluation of cardiovascular outcomes in adult patients with episodic or chronic migraine treated with galcanezumab: data from three phase 3, randomized, double-blind, placebo-controlled EVOLVE-1, EVOLVE-2, and REGAIN studies. Headache. https://doi.org/10.1111/head.13684

    Article  PubMed  Google Scholar 

Download references

Author information




All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by XZ, XX, and QL. The first draft of the manuscript was written by XZ and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xiaolin Xu.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhao, X., Xu, X. & Li, Q. Efficacy and safety of galcanezumab for preventive treatment of migraine: a systematic review and meta-analysis. J Neurol (2020). https://doi.org/10.1007/s00415-020-09707-5

Download citation


  • Galcanezumab
  • Migraine
  • Prophylaxis
  • Meta-analysis