Balanced sex distribution in patients with Menière’s disease

  • Sandra Becker-BenseEmail author
  • Constanze Wittmann
  • Marianne Dieterich
Letter to the Editors

Dear Sirs,

Menière’s disease (MD) is an inner ear disorder characterized by spontaneous attacks of vertigo, unilateral fluctuating hearing loss, aural fullness, and tinnitus [ 1]. With the exception of two very early reports, previous studies over the last five decades consistently reported a more or less distinct female-to-male preponderance in patients with MD (female:male ratio between 1.13:1 and 4.33:1, mean over all studies 1.63:1; please see literature review Table  1A) [ 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20], with considerable methodological differences. These earlier studies (a) used different study designs and recruitment strategies (e.g., academic specialized neurology/otology centers/general hospitals/general practitioners, regional/cross-regional population register based, clinical retrospective cohort analyses), (b) referred to varying populations (different ages, ethnic groups, sample sizes, inpatients and outpatients), and (c) applied...



We thank Katie Göttlinger for copyediting the manuscript. This work is part of the unpublished doctoral thesis of Constanze Wittmann.

Compliance with ethical standards

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Financial disclosure

The study was not industry sponsored. This work was supported by the German Federal Ministry of Education and Research (BMBF, Grant codes 01 EO 0901 and 01 EO 1401), the Deutsche Forschungsgemeinschaft (German Research Foundation) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy), and the Deutsche Stiftung Neurologie (DSN).

Ethical standards statement

The study has been approved by the local ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Sandra Becker-Bense
    • 1
    • 2
    Email author
  • Constanze Wittmann
    • 1
    • 2
  • Marianne Dieterich
    • 1
    • 2
    • 3
  1. 1.Department of Neurology and DSGZLudwig-Maximilians-Universität MünchenMunichGermany
  2. 2.German Center for Vertigo and Balance Disorders-IFB (DSGZ LMU)Ludwig-Maximilians-Universität MünchenMunichGermany
  3. 3.Munich Cluster of Systems Neurology (SyNergy)MunichGermany

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