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Journal of Neurology

, Volume 266, Issue 6, pp 1389–1393 | Cite as

Granulomatous CNS inflammation associated with seminoma

  • Jennifer Massey
  • Susan Walker
  • Malcolm Galloway
  • Suran Fernando
  • John Parratt
  • Ann-Marie Quigley
  • Desmond P. KiddEmail author
Original Communication
  • 97 Downloads

Abstract

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment.

Keywords

Sarcoidosis Neurosarcoidosis Seminoma 

Notes

Author contributions

SW and JM were joint first authors. JM SW, MG and DPK were responsible for the study concept and design, acquisition of data and analysis and interpretation. All authors were responsible for a critical revision of the manuscript for important intellectual content. DPK was the study supervisor.

Funding

Dr. Kidd receives royalties from Elsevier and Springer-Verlag. He reports no other disclosures. Dr. Massey has received honoraria from Biogen Idec, Merck, Sanofi Genzyme and Teva, outside the submitted work.

Compliance with ethical standards

Conflicts of interest

There are no conflicts of interest.

Ethical standards

Both patients consented to their clinical details being reported and the work has been conducted in compliance with the Declaration of Helsinki.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurologyRoyal North Shore HospitalSydneyAustralia
  2. 2.Department of ImmunologyRoyal North Shore HospitalSydneyAustralia
  3. 3.Department of NeurologyRoyal Free HospitalLondonUK
  4. 4.Department of Cellular PathologyRoyal Free HospitalLondonUK
  5. 5.Department of Nuclear MedicineRoyal Free HospitalLondonUK
  6. 6.Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and TransplantationUniversity College LondonLondonUK

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