Journal of Neurology

, Volume 266, Issue 6, pp 1389–1393 | Cite as

Granulomatous CNS inflammation associated with seminoma

  • Jennifer Massey
  • Susan Walker
  • Malcolm Galloway
  • Suran Fernando
  • John Parratt
  • Ann-Marie Quigley
  • Desmond P. KiddEmail author
Original Communication


Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment.


Sarcoidosis Neurosarcoidosis Seminoma 


Author contributions

SW and JM were joint first authors. JM SW, MG and DPK were responsible for the study concept and design, acquisition of data and analysis and interpretation. All authors were responsible for a critical revision of the manuscript for important intellectual content. DPK was the study supervisor.


Dr. Kidd receives royalties from Elsevier and Springer-Verlag. He reports no other disclosures. Dr. Massey has received honoraria from Biogen Idec, Merck, Sanofi Genzyme and Teva, outside the submitted work.

Compliance with ethical standards

Conflicts of interest

There are no conflicts of interest.

Ethical standards

Both patients consented to their clinical details being reported and the work has been conducted in compliance with the Declaration of Helsinki.


  1. 1.
    Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis (2007) N Engl J Med 357(21):2153–2165CrossRefGoogle Scholar
  2. 2.
    Kidd DP (2018) Sarcoidosis of the central nervous system: clinical features, imaging and CSF results. J Neurol 265:1906–1915CrossRefGoogle Scholar
  3. 3.
    Fritz D, van de Beek D, Brouwer MC (2016) Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis. BMC Neurol 16(1):220CrossRefGoogle Scholar
  4. 4.
    Paparel P, Devonec M, Perrin P, Ruffion A, Decaussin-Petrucci M, Akin O et al (2007) Association between sarcoidosis and testicular carcinoma: a diagnostic pitfall. Sarcoidosis Vasc Diffuse Lung Dis 24(2):95–101Google Scholar
  5. 5.
    Blacher EJ, Maynard JF (1985) Seminoma and sarcoidosis: an unusual association. Urology 26(3):288–289CrossRefGoogle Scholar
  6. 6.
    Brincker H (1995) Sarcoidosis and malignancy. Chest 108(5):1472–1474CrossRefGoogle Scholar
  7. 7.
    Claus F, De Wever L, Moerman P (2012) Coincidence of seminoma and sarcoidosis in two patients presenting with peritoneal surface disease. Int J Urol 19(12):1126CrossRefGoogle Scholar
  8. 8.
    Nonomura N, Nagahara A, Oka D, Mukai M, Nakai Y, Nakayama M et al (2009) Brain metastases from testicular germ cell tumors: a retrospective analysis. Int J Urol 16(11):887–893CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurologyRoyal North Shore HospitalSydneyAustralia
  2. 2.Department of ImmunologyRoyal North Shore HospitalSydneyAustralia
  3. 3.Department of NeurologyRoyal Free HospitalLondonUK
  4. 4.Department of Cellular PathologyRoyal Free HospitalLondonUK
  5. 5.Department of Nuclear MedicineRoyal Free HospitalLondonUK
  6. 6.Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and TransplantationUniversity College LondonLondonUK

Personalised recommendations