Granulomatous CNS inflammation associated with seminoma
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Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment.
KeywordsSarcoidosis Neurosarcoidosis Seminoma
SW and JM were joint first authors. JM SW, MG and DPK were responsible for the study concept and design, acquisition of data and analysis and interpretation. All authors were responsible for a critical revision of the manuscript for important intellectual content. DPK was the study supervisor.
Dr. Kidd receives royalties from Elsevier and Springer-Verlag. He reports no other disclosures. Dr. Massey has received honoraria from Biogen Idec, Merck, Sanofi Genzyme and Teva, outside the submitted work.
Compliance with ethical standards
Conflicts of interest
There are no conflicts of interest.
Both patients consented to their clinical details being reported and the work has been conducted in compliance with the Declaration of Helsinki.
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