Journal of Neurology

, Volume 265, Supplement 1, pp 26–28 | Cite as

MicroRNA profile of human endo-/perilymph

  • Markus Rohde
  • Inga Sinicina
  • Anja Horn
  • Norbert Eichner
  • Gunter Meister
  • Michael Strupp
  • Susanne Himmelein
Letter to the Editors

Dear Sirs,

The fluids of the human inner ear (endolymph and perilymph) are a self-contained system without any direct connection to other body fluids. Therefore, the composition of these fluids is unique. Both fluids differ in their ionic composition, which has to be maintained to ensure auditory and vestibular function within the inner ear. While the ionic concentration of the perilymph is more like that of other extracellular fluids, the composition of the endolymph is comparable to the cytosol [ 1, 2, 3]. Studies on the proteome of the perilymph also showed a high similarity with body fluids like blood plasma and cerebrospinal fluids (CSF) in humans [ 4, 5]. However, studies concentrating on the miRNA profile of the human endo-/perilymph are lacking. miRNAs are small, 19–24 nucleotide-long, non-coding RNA fragments that play a major role in the regulation of gene expression in a variety of processes [ 6]. Differential miRNA expression profiles in blood as well as in CSF have been...



Funded by the German Federal Ministry of Education and Research (German Center for Vertigo and Balance Disorders, Grant code 01EO1401). We thank Katie Göttlinger for copyediting the manuscript.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standard statement

The study was approved by the Ethical Committee of the Medical Faculty of the Ludwig Maximilians University of Munich. For blood samples signed written consent was obtained from all participants. No written consent was given for endo-/perilymph as they were obtained post-mortem.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Markus Rohde
    • 1
    • 2
  • Inga Sinicina
    • 3
  • Anja Horn
    • 2
    • 4
  • Norbert Eichner
    • 5
  • Gunter Meister
    • 5
  • Michael Strupp
    • 1
    • 2
  • Susanne Himmelein
    • 1
    • 2
  1. 1.Department of Neurology, German Center for Vertigo and Balance Disorders, DSGZ, Klinikum GrosshadernLudwig Maximilians UniversityMunichGermany
  2. 2.German Center for Vertigo and Balance Disorders, DSGZLudwig Maximilians UniversityMunichGermany
  3. 3.Department of Legal MedicineLudwig Maximilians UniversityMunichGermany
  4. 4.Institute of Anatomy and Cell Biology ILudwig Maximilians UniversityMunichGermany
  5. 5.Laboratory for RNA BiologyBiochemistry Center Regensburg (BZR)RegensburgGermany

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