Genetic contribution to vestibular diseases

Abstract

Growing evidence supports the contribution of allelic variation to vestibular disorders. Heritability attributed to rare allelic variants is found in familial vestibular syndromes such as enlarged vestibular aqueduct syndrome or familial Meniere disease. However, the involvement of common allelic variants as key regulators of physiological processes in common and rare vestibular diseases is starting to be deciphered, including motion sickness or sporadic Meniere disease. The genetic contribution to most of the vestibular disorders is still largely unknown. This review will outline the role of common and rare variants in human genome to episodic vestibular syndromes, progressive vestibular syndrome, and hereditary sensorineural hearing loss associated with vestibular phenotype. Future genomic studies and network analyses of omic data will clarify the pathway towards a personalized stratification of treatments.

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Acknowledgements

The authors are supported by Grants from Meniere’s Society, UK (MS-2016-17 Grant), PI17/01644 Grant from ISCIII by FEDER Funds from EU, H2020-MSCA-ITN-2016-722046 from EU and Luxembourg National Research Fund (INTER/Mobility/17/11772209).

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Correspondence to Jose Antonio Lopez-Escamez.

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The authors declare no competing conflict of interest.

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This manuscript is part of a supplement sponsored by the German Federal Ministry of Education and Research within the funding initiative for integrated research and treatment centers.

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Gallego-Martinez, A., Espinosa-Sanchez, J.M. & Lopez-Escamez, J.A. Genetic contribution to vestibular diseases. J Neurol 265, 29–34 (2018). https://doi.org/10.1007/s00415-018-8842-7

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Keywords

  • Dizziness
  • Vestibular disorders
  • Genetics
  • Meniere disease
  • Vestibular migraine