Genetic contribution to vestibular diseases

  • Alvaro Gallego-Martinez
  • Juan Manuel Espinosa-Sanchez
  • Jose Antonio Lopez-Escamez
Review

Abstract

Growing evidence supports the contribution of allelic variation to vestibular disorders. Heritability attributed to rare allelic variants is found in familial vestibular syndromes such as enlarged vestibular aqueduct syndrome or familial Meniere disease. However, the involvement of common allelic variants as key regulators of physiological processes in common and rare vestibular diseases is starting to be deciphered, including motion sickness or sporadic Meniere disease. The genetic contribution to most of the vestibular disorders is still largely unknown. This review will outline the role of common and rare variants in human genome to episodic vestibular syndromes, progressive vestibular syndrome, and hereditary sensorineural hearing loss associated with vestibular phenotype. Future genomic studies and network analyses of omic data will clarify the pathway towards a personalized stratification of treatments.

Keywords

Dizziness Vestibular disorders Genetics Meniere disease Vestibular migraine 

Notes

Acknowledgements

The authors are supported by Grants from Meniere’s Society, UK (MS-2016-17 Grant), PI17/01644 Grant from ISCIII by FEDER Funds from EU, H2020-MSCA-ITN-2016-722046 from EU and Luxembourg National Research Fund (INTER/Mobility/17/11772209).

Compliance with ethical standards

Conflicts of interest

The authors declare no competing conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Otology and Neurotology Group CTS495, Department of Genomic MedicineCentre for Genomics and Oncological Research-Pfizer/University of Granada/Andalusian Regional Government (GENYO)GranadaSpain
  2. 2.Luxembourg Centre for Systems Biomedicine (LCSB)University of LuxembourgEsch-sur-AlzetteLuxembourg
  3. 3.Department of Otolaryngology, Instituto de Investigación Biosanitaria ibs.GRANADAHospital Universitario Virgen de las NievesGranadaSpain

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