Journal of Neurology

, Volume 265, Issue 4, pp 968–969 | Cite as

Early-onset subcortical ischemic vascular dementia in an adult with mtDNA mutation 3316G>A

  • Giuseppe Lanza
  • Mariagiovanna Cantone
  • Sabrina Musso
  • Eugenia Borgione
  • Carmela Scuderi
  • Raffaele Ferri
Letter to the Editors

Dear Sirs,

The term subcortical ischemic vascular disease (SIVD) identifies a clinically homogeneous group of patients at risk for future vascular dementia (VaD) [1]. However, while cerebrovascular changes are common findings in aged subjects with or without dementia, etiology of dementing disorders in younger patients is challenging and often undetermined. We report a young woman without any conventional vascular risk factor, with a typical neuroimaging pattern of SIVD, and a clinical-cognitive profile of VaD.

A 59-year old woman complained about a 6-year history of progressive cognitive deterioration, along with apathy and depressive symptoms. Family and past medical history were uneventful. She did not take any medication. General and neurological examinations were within normal limits, except for diffuse brisk tendon reflexes. A comprehensive neuropsychological battery disclosed a global cognitive decline involving multiple domains (especially at executive functions,...


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standards

The authors state that they acted in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Oasi Research Institute – IRCCSTroinaItaly

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