Early-onset subcortical ischemic vascular dementia in an adult with mtDNA mutation 3316G>A
The term subcortical ischemic vascular disease (SIVD) identifies a clinically homogeneous group of patients at risk for future vascular dementia (VaD) . However, while cerebrovascular changes are common findings in aged subjects with or without dementia, etiology of dementing disorders in younger patients is challenging and often undetermined. We report a young woman without any conventional vascular risk factor, with a typical neuroimaging pattern of SIVD, and a clinical-cognitive profile of VaD.
Compliance with ethical standards
Conflicts of interest
The authors declare that they have no conflict of interest.
The authors state that they acted in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments.
- 1.Jokinen H, Kalska H, Ylikoski R, Madureira S, Verdelho A, van der Flier WM, Scheltens P, Barkhof F, Visser MC, Fazekas F, Schmidt R, O’Brien J, Waldemar G, Wallin A, Chabriat H, Pantoni L, Inzitari D, Erkinjuntti T, LADIS Group (2009) Longitudinal cognitive decline in subcortical ischemic vascular disease: the LADIS Study. Cerebrovasc Dis 27:384–391. https://doi.org/10.1159/000207442 CrossRefPubMedGoogle Scholar
- 6.Carnevale D, Mascio G, D’Andrea I et al (2012) Hypertension induces brain beta amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension 60:188–197CrossRefPubMedPubMedCentralGoogle Scholar