Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2
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We are grateful to Prof. Hidenao Sasaki for helpful comments. We thank Shoko Shimizu for preparation of this manuscript. This work was supported by JSPS KAKENHI Grant number 25893006.
HY, IY and HT designed and performed experiments, analyzed and interpreted data and drafted the manuscript and figures. MW, TN, TK, MW and SH conceived and designed the study and critically revised the manuscript. All authors have seen and agree with the content of the manuscript. HY and IY contributed equally to this work.
Compliance with ethical standards
Conflicts of interest
All authors state that there is no conflict of interest.
This study was approved by the Institutional Review Board of Hokkaido University Hospital.
Written informed consent was obtained from the patient (Protocol number 012-0167).
- 1.Hoftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J (2015) Encephalitis and AMPA receptor antibodies: novel findings in a case series of 22 patients. Neurology 84:2403–2412CrossRefPubMedPubMedCentralGoogle Scholar
- 4.Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H, Nanri K, Shanmugarajah P, Yoneda M, Yuki N (2016) Consensus paper: neuroimmune mechanisms of cerebellar ataxias. Cerebellum (London, England) 15:213–232CrossRefGoogle Scholar
- 5.Miyazaki T, Hashimoto K, Uda A, Sakagami H, Nakamura Y, Saito SY, Nishi M, Kume H, Tohgo A, Kaneko I, Kondo H, Fukunaga K, Kano M, Watanabe M, Takeshima H (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett 580:4057–4064CrossRefPubMedGoogle Scholar