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Journal of Neurology

, Volume 265, Issue 4, pp 845–855 | Cite as

MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein

  • Matthias Baumann
  • Astrid Grams
  • Tanja Djurdjevic
  • Eva-Maria Wendel
  • Christian Lechner
  • Bettina Behring
  • Astrid Blaschek
  • Katharina Diepold
  • Astrid Eisenkölbl
  • Joel Fluss
  • Michael Karenfort
  • Johannes Koch
  • Bahadir Konuşkan
  • Steffen Leiz
  • Andreas Merkenschlager
  • Daniela Pohl
  • Mareike Schimmel
  • Charlotte Thiels
  • Barbara Kornek
  • Kathrin Schanda
  • Markus Reindl
  • Kevin Rostásy
Original Communication

Abstract

Antibodies against the myelin oligodendrocyte glycoprotein (MOG-Ab) can be detected in various pediatric acquired demyelinating syndromes (ADS). Here, we analyze the spectrum of neuroradiologic findings in children with MOG-Ab and a first demyelinating event. The cerebral and spinal MRI of 69 children with different ADS was assessed in regard to the distribution and characteristics of lesions. Children with acute disseminated encephalomyelitis (n = 36) or neuromyelitis optica spectrum disorder (n = 5) presented an imaging pattern characterized predominantly by poorly demarcated lesions with a wide supra- and infratentorial distribution. Younger children also tended to have poorly defined and widespread lesions. The majority of patients with an isolated optic neuritis (n = 16) only presented small non-specific brain lesions or none at all. A longitudinally extensive transverse myelitis mainly affecting the cervical, and less often so the thoracic, lumbar, and conus regions, was detected in 31 children. The three children of our cohort who were then finally diagnosed with multiple sclerosis had at onset already demarcated white matter lesions as well as transverse myelitis. In conclusion, children with MOG seropositive ADS present disparate, yet characteristic imaging patterns. These patterns have been seen to correlate to the disease entity as well as to age of symptom onset.

Keywords

Pediatric acquired demyelinating syndromes Myelin oligodendrocyte glycoprotein Acute disseminated encephalomyelitis Neuromyelitis optica spectrum disorder Multiple sclerosis Magnetic resonance imaging 

Notes

Acknowledgements

This work was supported by a grant from the Anniversary Fund of the Austrian National Bank to KR (Grant number 14158); and the research grant “BIG WIG MS” from the Austrian Federal Ministry of Science, Research and Economy to MR.

Compliance with ethical standards

Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standards

Approval for this study was obtained from the institution’s review board. All included patients or caregivers provided written informed consent.

Supplementary material

415_2018_8781_MOESM1_ESM.pdf (756 kb)
Supplementary material 1 (PDF 756 kb)
415_2018_8781_MOESM2_ESM.pdf (576 kb)
Supplementary material 2 (PDF 575 kb)
415_2018_8781_MOESM3_ESM.pdf (91 kb)
Supplementary material 3 (PDF 91 kb)
415_2018_8781_MOESM4_ESM.pdf (48 kb)
Supplementary material 4 (PDF 47 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pediatric Neurology, Department of Pediatrics IMedical University of InnsbruckInnsbruckAustria
  2. 2.Department of NeuroradiologyMedical University of InnsbruckInnsbruckAustria
  3. 3.Department of PediatricsOlga HospitalStuttgartGermany
  4. 4.Department of PediatricsKlinikum NurembergNurembergGermany
  5. 5.Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner’s Children’s HospitalUniversity of MunichMunichGermany
  6. 6.Division of Pediatric Neurology, Department of PediatricsKlinikum KasselKasselGermany
  7. 7.Department of PediatricsWomen’s and Children’s HospitalLinzAustria
  8. 8.Pediatric NeurologyGeneva Children’s HospitalGenevaSwitzerland
  9. 9.Department of General Paediatrics, Neonatology and Paediatric CardiologyHeinrich Heine UniversitätDüsseldorfGermany
  10. 10.Department of PediatricsSalzburger Landeskliniken and Paracelsus Medical UniversitySalzburgAustria
  11. 11.Department of Pediatric Neurology, Faculty of MedicineHacettepe UniversityAnkaraTurkey
  12. 12.Division of Pediatric Neurology, Department of PediatricsKlinikum Dritter OrdenMunichGermany
  13. 13.Hospital for Children and AdolescentsUniversity of LeipzigLeipzigGermany
  14. 14.Department of Neurology, Children’s Hospital of Eastern OntarioUniversity of OttawaOttawaCanada
  15. 15.Division of Pediatric Neurology, Children’s HospitalKlinikum AugsburgAugsburgGermany
  16. 16.Department of Neuropediatrics, University Children’s HospitalRuhr-University BochumBochumGermany
  17. 17.Institute of NeurologyMedical University of ViennaViennaAustria
  18. 18.Clinical Department of NeurologyMedical University of InnsbruckInnsbruckAustria
  19. 19.Department of Pediatric Neurology, Children’s Hospital DattelnWitten/Herdecke UniversityDattelnGermany

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