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Journal of Neurology

, Volume 264, Issue 11, pp 2205–2214 | Cite as

Characterization of brain tumours with spin–spin relaxation: pilot case study reveals unique T 2 distribution profiles of glioblastoma, oligodendroglioma and meningioma

  • Cornelia LauleEmail author
  • Thorarin A. Bjarnason
  • Irene M. Vavasour
  • Anthony L. Traboulsee
  • G. R. Wayne Moore
  • David K. B. Li
  • Alex L. MacKay
Original Communication

Abstract

Prolonged spin–spin relaxation times in tumour tissue have been observed since some of the earliest nuclear magnetic resonance investigations of the brain. Over the last three decades, numerous studies have sought to characterize tumour morphology and malignancy using quantitative assessment of T 2 relaxation times, although attempts to categorize and differentiate tumours have had limited success. However, previous work must be interpreted with caution as relaxation data were typically acquired using a variety of multiple echo sequences with a range of echoes and T 2 decay curves and were frequently fit with monoexponential analysis. We defined the distribution of T 2 components in three different human brain tumours (glioblastoma, oligodendroglioma, meningioma) using a multi-echo sequence with a greater number of echoes and a longer acquisition window than previously used (48 echoes, data collection out to 1120 ms) with no a priori assumptions about the number of exponential components contributing to the T 2 decay. T 2 relaxation times were increased in tumour tissue and each tumour showed a distinct T 2 distribution profile. Tumours have complex and unique compartmentalization characteristics. Quantitative assessment of T 2 relaxation in brain cancer may be useful in evaluating different grades of brain tumours on the basis of their T 2 distribution profile, and has the potential to be a non-invasive diagnostic tool which may also be useful in monitoring therapy. Further study with a larger sample size and varying grades of tumours is warranted.

Keywords

Tumour MRI T2 relaxation Edema Glioblastoma Oligodendroglioma Meningioma 

Notes

Acknowledgements

Sincere thanks to the subjects, MRI technologists, neuropathologists and surgeons and the MS Society of Canada. Thank you to Katy Wyper for assistance with the literature search. CL was the recipient of the Women Against MS (WAMS) endMS Research and Training Network Transitional Career Development Award from the Multiple Sclerosis Society of Canada.

Compliance with ethical standards

Conflicts of interest

On behalf of all authors the corresponding author states that there is no relevant conflict of interest with respect to the content of this manuscript.

Ethical standards

This study was approved by the Clinical Research Ethics Board at the University of British Columbia with written informed consent obtained from all subjects in accordance with the Declaration of Helsinki of 1964 and its later amendments.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.RadiologyUniversity of British ColumbiaVancouverCanada
  2. 2.Pathology and Laboratory MedicineUniversity of British ColumbiaVancouverCanada
  3. 3.Blusson Spinal Cord Centre/ICORD (International Collaboration on Repair Discoveries)VancouverCanada
  4. 4.Diagnostic Imaging ServicesInterior HealthKelownaCanada
  5. 5.PhysicsUniversity of British Columbia OkanaganKelownaCanada
  6. 6.MedicineUniversity of British ColumbiaVancouverCanada
  7. 7.UBC MRI Research CentreUniversity of British ColumbiaVancouverCanada
  8. 8.Physics and AstronomyUniversity of British ColumbiaVancouverCanada

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