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Vaccines and multiple sclerosis: a systematic review

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Abstract

Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles–mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

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Authors and Affiliations

  1. University of Copenhagen, Copenhagen, Denmark

    Mia Topsøe Mailand

  2. Department of Neurology, University of Copenhagen, Rigshospitalet Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark

    Jette Lautrup Frederiksen

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  1. Mia Topsøe Mailand
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  2. Jette Lautrup Frederiksen
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Correspondence to Jette Lautrup Frederiksen.

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Mailand, M.T., Frederiksen, J.L. Vaccines and multiple sclerosis: a systematic review. J Neurol 264, 1035–1050 (2017). https://doi.org/10.1007/s00415-016-8263-4

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  • DOI: https://doi.org/10.1007/s00415-016-8263-4

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