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Cortical thinning in drug-naive Parkinson’s disease patients with depression

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Abstract

To shed more light on the contribution of brain structural changes to PD-related depressive symptoms, this study conducted cortical thickness analysis in drug-naive PD patients with and without depression. We recruited 27 PD patients with depression (PD-Dep), 29 PD patients without depression (PD-NDep), and 56 normal controls. T1 weighted magnetic resonance imaging and surface-based morphometric analyses were performed to examine morphometric abnormalities in PD patients and their relationship to depression. We found decreased thickness in the left prefrontal cortex in PD-Dep group compared with PD-NDep group. No significant difference was found between PD patients and controls. In addition, we found there is a trend of inverse correlation between the structural changes and the score of depressive symptom in depressed PD patients. This study demonstrates that cortical thinning in prefrontal area in drug-naive PD patients with depression and highlights the critical role of prefrontal region in the depression associated with PD.

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Authors and Affiliations

  1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

    ChunYan Luo, Wei Song, Qin Chen, Jing Yang & Hui-Fang Shang

  2. Department of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, China

    QiYong Gong

Authors
  1. ChunYan Luo
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  2. Wei Song
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  3. Qin Chen
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  4. Jing Yang
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  5. QiYong Gong
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  6. Hui-Fang Shang
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Correspondence to QiYong Gong or Hui-Fang Shang.

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The study has been approved by the local research ethics committee.

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All subjects gave written informed consent for participation.

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Luo, C., Song, W., Chen, Q. et al. Cortical thinning in drug-naive Parkinson’s disease patients with depression. J Neurol 263, 2114–2119 (2016). https://doi.org/10.1007/s00415-016-8241-x

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  • DOI: https://doi.org/10.1007/s00415-016-8241-x

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