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Journal of Neurology

, Volume 263, Issue 4, pp 792–798 | Cite as

Migration and multiple sclerosis in immigrants from United Kingdom and Ireland to Australia: a reassessment. III: risk of multiple sclerosis in UKI immigrants and Australian-born in Hobart, Tasmania

  • Michael H. BarnettEmail author
  • James G. McLeod
  • Simon R. Hammond
  • John F. Kurtzke
Original Communication

Abstract

Our previous work suggested that migrants from the United Kingdom and Ireland (UKI) to Australia who left their home country at a young age had a longer interval between immigration and onset and likely acquired MS in Australia. In the present study, we reassessed Australian-born cases of MS identified in Hobart, Tasmania, a relatively high-risk zone, in our 1981 survey and compared these with cases of MS in UKI immigrants incident in Australia. The incidence of MS in Australian-born residents rose from 1.63 per 100,000 in 1941–1965 to 3.48 per 100,000 in 1966–1981. The bulk of UKI immigrants who developed MS in Australia migrated after the age of 15 years, and likely acquired their disease in the UKI. The mean interval from immigration to onset differed significantly (p < 0.01) between those migrating before (22 years) versus after (6 years) the age of 15, suggesting acquisition of MS in Australia in the former group. Identified environmental risk factors such as smoking, sunlight and exposure to Epstein-Barr virus do not fully account for the epidemiology of multiple sclerosis. The apparent introduction of MS into Hobart from the mid-1940s on could provide circumstantial support for the theory that MS is a transmissible disease.

Keywords

Multiple sclerosis Epidemiology Australia Migration Environment Latent infection 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical standard

This work was approved by the Human Research and Ethics Committee of the University of Sydney and was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

All participants in the earlier prevalence studies on which this work is based had given their informed consent prior to their inclusion in the study.

Supplementary material

415_2016_8059_MOESM1_ESM.docx (35 kb)
Supplementary material 1 (DOCX 34 kb)
415_2016_8059_MOESM2_ESM.docx (127 kb)
Average annual multiple sclerosis incidence rates per 100,000 person-years in Australian-born in Hobart surviving to 1981 (DOCX 127 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Brain and Mind CentreUniversity of SydneyCamperdownAustralia
  2. 2.Central West Neurology and NeurosurgeryOrangeAustralia
  3. 3.Department of NeurologyGeorgetown UniversityWashingtonUSA

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