Abstract
The multimodal assessment of capacities in severe dementia (MAC-SD), a novel cognitive and functional assessment, was developed for use with patients with severe dementia. Its psychometric attributes were examined in a unicenter, open, observational study. The MAC-SD along with the Spanish language Severe Mini Mental Exam were administered to 103 patients with a diagnosis of severe dementia. Psychometric analyses were performed to determine acceptability, reliability, validity, and responsiveness. As a whole, the MAC-SD sections showed no floor effects, satisfactory internal consistency, reproducibility, construct validity, precision, and sensitivity to change. The MAC-SD performed as a useful, valid, and potentially responsive tool to measure cognition and functioning in the most advanced stages of dementia.
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Acknowledgments
This work was supported by funding from the William J. Fulbright US Student Program, International Institute of Education and the Comisión Fulbright in Madrid, Spain. The authors would like to thank Laura Fernandez Perez and the staff of the Centro Alzheimer Reina Sofia for their collaboration in bringing this project to fruition, and Harris Eppsteiner for assistance with data analysis.
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On behalf of all the authors, the corresponding author states that there is no conflict of interest.
Ethical standard
The study was approved by the Institutional Review Board of the Alzheimer’s Disease Research Unit, CIEN Foundation, and the Ethics Committee of the Carlos III Institute of Health. Informed written consent was obtained from the next of kin or legal representative of each participant.
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Heller, S., Rebolledo, C.M., Blázquez, C.R. et al. Validation of the multimodal assessment of capacities in severe dementia: a novel cognitive and functional scale for use in severe dementia. J Neurol 262, 1198–1208 (2015). https://doi.org/10.1007/s00415-015-7692-9
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DOI: https://doi.org/10.1007/s00415-015-7692-9