Journal of Neurology

, Volume 262, Issue 1, pp 81–90 | Cite as

Post-stroke depression and lesion location: a systematic review

  • Na Wei
  • Wu Yong
  • Xinyan Li
  • Yafan Zhou
  • Manfei Deng
  • Houze Zhu
  • Huijuan JinEmail author
Original Communication


Post-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published. The aim of the present study was to perform a systematic meta-analysis to evaluate the relationship between PSD and lesion location. We researched PubMed, ISI Web of Science, EMBASE, and systematically reviewed available publications reporting investigations on stroke location and risk of PSD. Subgroup analyses were performed according to the time since stroke onset to assessment for PSD or the source of patients. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used for pooled analyses. Heterogeneity was assessed with Cochran’s Q test and I 2 test. Begg’s funnel plot and Egger’s test were used to examine the publication bias. A total of 43 studies involving 5,507 patients suffering from stroke were included in this meta-analysis. The pooled OR with 95 % CI for the overall association of stroke location and depression risk was 0.99 (0.88–1.11). Subgroups analyses highlighted that only studies with subacute post-stroke group (1–6 months) showed a statistical association between right hemisphere stroke and risk of depression (OR = 0.79, 95 % CI 0.66–0.93). This systematic review offered no support for the hypothesis that lesion of the left hemisphere was associated with an increased risk of depression after stroke. We only find significant association between right hemisphere stroke and incidence of depression for studies within subacute post-stroke phase.


Post-stroke depression Lesion location Meta-analysis 



This work was supported by National Natural Science Foundation of China (81301165 to Jin H), Natural Science Fund of Hubei Province (2012FFB03706 to Jin H) and China Postdoctoral Science Foundation (2014M552047 to Jin H).

Conflicts of interest

The authors declare that there is no conflict of interest.

Supplementary material

415_2014_7534_MOESM1_ESM.doc (172 kb)
Supplementary material 1 (DOC 172 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Na Wei
    • 1
  • Wu Yong
    • 2
  • Xinyan Li
    • 1
  • Yafan Zhou
    • 1
  • Manfei Deng
    • 1
  • Houze Zhu
    • 1
  • Huijuan Jin
    • 1
    Email author
  1. 1.Institute of Brain ResearchHuazhong University of Science and TechnologyWuhanChina
  2. 2.Institute of PsychologyChinese Academy of SciencesBeijingChina

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