Patterns of regional gray matter and white matter atrophy in cortical multiple sclerosis
- 534 Downloads
We investigated the patterns of regional distribution of focal lesions, white matter (WM) and gray matter (GM) atrophy in patients with cortical (cort) MS in comparison to classical (c) MS patients. Nine cort-MS, nine c-MS and nine age-matched healthy controls (HC) underwent a brain MRI exam, including FLAIR and high-resolution T1-weighted scans. MS patients underwent neurological and neuropsychological assessment. Between-group differences of GM and WM volumes and their correlations with neuropsychological performances were assessed with voxel-based morphometry. FLAIR and T1 lesion probability maps (LPMs) were also obtained. Performance at neuropsychological tests was worse in cort-MS than in c-MS patients. Compared to HC, MS patients had a distributed pattern of GM and WM atrophy. No GM/WM area was more atrophic in c-MS vs cort-MS patients. Compared to c-MS, cort-MS patients experienced GM atrophy of frontal–temporal–parietal areas and cingulate cortex and WM atrophy of the cingulum bundle, bilateral cerebral peduncles, right inferior longitudinal fasciculus and left superior longitudinal fasciculus. FLAIR and T1 LPMs did not differ between c-MS vs cort-MS patients. A higher susceptibility to neurodegenerative processes in key brain regions known to be related to cognitive functions is likely to underlie the clinical manifestations of cort-MS.
KeywordsCortical multiple sclerosis MRI Regional damage White matter Gray matter
Conflicts of interests
Laura Parisi, Flavia Mattioli, Ruggero Capra, Chiara Stampatori, and Fabio Bellomi report no disclosures.
Maria A. Rocca received speakers honoraria from Biogen Idec, Novartis and Serono Symposia International Foundation and receives research support from the Italian Ministry of Health and Fondazione Italiana Sclerosi Multipla.
Massimo Filippi serves on scientific advisory board for Teva Pharmaceutical Industries; has received compensation for consulting services and/or speaking activities from Bayer Schering Pharma, Biogen Idec, Merck Serono, and Teva Pharmaceutical Industries; and receives research support from Bayer Schering Pharma, Biogen Idec, Merck Serono, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, Cure PSP, and the Jacques and Gloria Gossweiler Foundation (Switzerland).
This study was approved by the Local Ethical Committes on human studies and written informed consent from each subject was obtained prior to their enrolment.
Statement of Human and Animal Rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
This article does not contain any studies with animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
- 11.Novelli GPC, Capitani E, Laiacona M, Cappa SF, Vallar G (1986) Tre test clinici di memoria verbale a lungo termine. Taratura su soggetti normali. Archivio di Psicologia Neurologia e Psichiatria 2:278–296Google Scholar
- 12.Spinnler HTG (1987) Standardizzazione e taratura italiana di test psicometrici. Ital J Neurol Sci 8:7–120Google Scholar
- 19.Mori S, Wakana S, Van Zijl PCM, Nagae-Poetscher LM (2005) MRI atlas of human white matter. Elsevier, AmsterdamGoogle Scholar