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Altered GABAergic system in the living brain of a patient with spinocerebellar ataxia type 8

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References

  1. Daughters RS, Tuttle DL, Gao W, Ikeda Y, Moseley ML, Ebner TJ, Swanson MS, Ranum LP (2009) RNA gain-of-function in spinocerebellar ataxia type 8. PLoS Genet 5:e1000600

    Article  PubMed  Google Scholar 

  2. Delforge J, Pappata S, Millet P, Samson Y, Bendriem B, Jobert A, Crouzel C, Syrota A (1995) Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 15:284–300

    Article  PubMed  CAS  Google Scholar 

  3. Grafman J, Litvan I, Massaquoi S, Stewart M, Sirigu A, Hallett M (1992) Cognitive planning deficit in patients with cerebellar atrophy. Neurology 42:1493–1496

    Article  PubMed  CAS  Google Scholar 

  4. Gupta A, Jankovic J (2009) Spinocerebellar ataxia 8: variable phenotype and unique pathogenesis. Parkinsonism Relat Disord 15:621–626

    Article  PubMed  Google Scholar 

  5. Ito H, Kawakami H, Wate R, Matsumoto S, Imai T, Hirano A, Kusaka H (2006) Clinicopathologic investigation of a family with expanded SCA8 CTA/CTG repeats. Neurology 67:1479–1481

    Article  PubMed  CAS  Google Scholar 

  6. Izumi Y, Maruyama H, Oda M, Morino H, Okada T, Ito H, Sasaki I, Tanaka H, Komure O, Udaka F, Nakamura S, Kawakami H (2003) SCA8 repeat expansion: large CTA/CTG repeat alleles are more common in ataxic patients, including those with SCA6. Am J Hum Genet 72:704–709

    Article  PubMed  CAS  Google Scholar 

  7. Lilja A, Hamalainen P, Kaitaranta E, Rinne R (2005) Cognitive impairment in spinocerebellar ataxia type 8. J Neurol Sci 237:31–38

    Article  PubMed  Google Scholar 

  8. Moseley ML, Zu T, Ikeda Y, Gao W, Mosemiller AK, Daughters RS, Chen G, Weatherspoon MR, Clark HB, Ebner TJ, Day JW, Ranum LP (2006) Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8. Nat Genet 38:758–769

    Article  PubMed  CAS  Google Scholar 

  9. Mutsuddi M, Rebay I (2005) Molecular genetics of spinocerebellar ataxia type 8 (SCA8). RNA Biol 2:49–52

    Article  PubMed  CAS  Google Scholar 

  10. Nyhus E, Barcelo F (2009) The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: a critical update. Brain Cogn 71:437–451

    Article  PubMed  Google Scholar 

  11. Pearl PL, Gibson KM, Quezado Z, Dustin I, Taylor J, Trzcinski S, Schreiber J, Forester K, Reeves-Tyer P, Liew C, Shamim S, Herscovitch P, Carson R, Butman J, Jakobs C, Theodore W (2009) Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency. Neurology 73:423–429

    Article  PubMed  CAS  Google Scholar 

  12. Salmi E, Kaisti KK, Metsahonkala L, Oikonen V, Aalto S, Nagren K, Hinkka S, Hietala J, Korpi ER, Scheinin H (2004) Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans. Anesth Analg 99:1420–1426

    Article  PubMed  CAS  Google Scholar 

  13. Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121(Pt 4):561–579

    Article  PubMed  Google Scholar 

  14. Stone J, Smith L, Watt K, Barron L, Zeman A (2001) Incoordinated thought and emotion in spinocerebellar ataxia type 8. J Neurol 248:229–232

    Article  PubMed  CAS  Google Scholar 

  15. Yamauchi H, Nishii R, Higashi T, Kagawa S, Fukuyama H (2011) Selective neuronal damage and Wisconsin Card Sorting Test performance in atherosclerotic occlusive disease of the major cerebral artery. J Neurol Neurosurg Psychiatry 82:150–156

    Article  PubMed  Google Scholar 

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Conflicts of interest

None.

Ethical standard

This study was reviewed and approved by the ethics committee of Hamamatsu University School of Medicine.

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Authors and Affiliations

  1. Department of Biofunctional Imaging, Medical Photonics Research Centre, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan

    Tatsuhiro Terada & Yasuomi Ouchi

  2. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

    Tatsuhiro Terada, Satoshi Kono, Takashi Konishi & Hiroaki Miyajima

Authors
  1. Tatsuhiro Terada
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  2. Satoshi Kono
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  3. Takashi Konishi
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  4. Hiroaki Miyajima
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  5. Yasuomi Ouchi
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Correspondence to Tatsuhiro Terada.

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Terada, T., Kono, S., Konishi, T. et al. Altered GABAergic system in the living brain of a patient with spinocerebellar ataxia type 8. J Neurol 260, 3164–3166 (2013). https://doi.org/10.1007/s00415-013-7167-9

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  • DOI: https://doi.org/10.1007/s00415-013-7167-9

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