Abstract
Few language disorders have been reported in posterior cortical atrophy (PCA). Furthermore, no study has focused on screening for them and described these language deficits. The goal of this work was to describe linguistic examination of PCA patients and the impact of language disorders on neuropsychological performances compared to patients with other neurodegenerative syndromes and control groups. Linguistic examination of 9 PCA patients was carried out. The neuropsychological performance of the PCA group (16 patients) in the RAPID battery tests was compared with performances of patients with a logopenic variant of primary progressive aphasia (LPPA), patients with Alzheimer’s disease and patients with amnestic mild cognitive impairment, as well as the control group. A “logopenic syndrome” with anomia, fluency impairment, and length-dependent deficit was found in 8/9 PCA patients. A comparison with other neurodegenerative syndromes showed that not only visual disorders but also language and verbal short-term memory disorders, such as those found in LPPA, can explain neuropsychological performances. A “logopenic syndrome” is frequently found in PCA and may be associated with poor performance on other verbally mediated neuropsychological tasks (e.g., verbal memory). Specific logopedic rehabilitation should be offered to these patients.
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References
Benson DF, Davis RJ, Snyder BD (1988) Posterior cortical atrophy. Arch Neurol 45:789–793
Tang-Wai DF, Graff-Radford NR, Boeve BF et al (2004) Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology 63:1168–1174
Lehmann M, Crutch SJ, Ridgway GR et al (2011) Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer’s disease. Neurobiol Aging 32:1466–1476
McMonagle P, Deering F, Berliner Y et al (2006) The cognitive profile of posterior cortical atrophy. Neurology 66:331–338
Migliaccio R, Agosta F, Rascovsky K et al (2009) Clinical syndromes associated with posterior cortical atrophy, early age at onset AD spectrum. Neurology 73:1571–1578
Mendez MF, Ghajarania M, Perryman KM (2005) Posterior cortical atrophy: clinical characteristics and differences compared to Alzheimer’s disease. Behav Neurol 16:15–23
Rogers TT, Ivanoiu A, Patterson K et al (2006) Semantic memory in Alzheimer’s disease and frontotemporal dementias: a longitudinal study of 236 patients. Neuropsychology 20:319–335
Crutch SJ, Lehmann M, Warren JD, et al. (2012) The language profile of posterior cortical atrophy. J Neurol Neurosurg Psychiatry (in press)
Gorno-Tempini ML, Brambati SM, Ginex V et al (2008) The logopenic/phonological variant of primary progressive aphasia. Neurology 71:1227–1234
Gorno-Tempini ML, Hillis AE, Weintraub S et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76(11):1006–1014
Ferreira S, Vanholsbeeck G, Chopard G et al (2010) Normes comparatives de la batterie de tests neuropsychologiques RAPID pour les sujets âgés de 50 à 89 ans. Rev Neurol (Paris) 166:606–614
Sylvestre G, Chopard G, Tio G et al (2011) Diagnostic norms of RAPID neuropsychological battery tests for subjects aged 60 to 89 years with Alzheimer’s disease. Rev Neurol (Paris) 167(6–7):495–504
Fazekas F, Kleinert R, Offenbacher H et al (1993) Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 43(9):1683–1689
Heijer T, Skoog I, Oudkerk M et al (2003) Association between blood pressure levels over time and brain atrophy in the elderly. Neurobiol Aging 24(2):307–313
Tison P (2002) Adaptation et validation d’un test de compréhension verbale pour des sujets agés détériorés. Revue de gériatrie 27(5):323–333
Deloche G, Hannequin D, Dordain M et al (1996) Picture confrontation oral naming: performance differences between aphasics and normals. Brain Lang 53(1):105–120
Beauvois MF, Saillant B (1985) Optic aphasia for colours and colour agnosia: a distinction between visual and visuo-verbal impairments in the processing of colours. Cogn Neuro psychol 2(1):1–48
Joanette Y, Ska B, Côté H (2004) Protocole Montréal d’Évaluation de la Communication. Ortho Édition, Isbergues
Cardebat D, Doyon B, Puel M et al (1990) Evocation lexicale formelle et sémantique chez des sujet normaux : performances et dynamique de production en fonction du sexe, de l’age et du niveau d’étude. Acta Neurol Belg 90:207–217
Petersen RC, Stevens JC, Ganguli M et al (2001) Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56(9):1133–1142
McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of health and human services task force on Alzheimer’s disease. Neurology 34(7):939–944
Gurd JM, Amunts K, Weiss PH et al (2002) Posterior parietal cortex is implicated in continuous switching between verbal fluency tasks: an fMRI study with clinical implications. Brain 125(5):1024–1038
Kertesz A, McMonagle P, Blair M et al (2005) The evolution and pathology of frontotemporal dementia. Brain 128(Pt 9):1996–2005
Caso F, Onofrio F, Falautano M, et al. (2012) From primary progressive aphasia to corticobasal syndrome: two clinical and rCBF functional reports. Neurocase in press doi: 10.1080/13554794.2012.667117
Crutch SJ, Lehmann M, Schott JM et al (2012) Posterior cortical atrophy. Lancet Neurol 11(2):170–178
Beeson PM, King RM, Bonakdarpour B et al (2011) Positive effects of language treatment for logopenic variant of primary progressive aphasia. J Mol Neurosci 45(3):724–736
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The authors wish to thank Frances Sheppard of the Clinical Investigation Center of Besançon for correcting and improving the English in the manuscript.
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Magnin, E., Sylvestre, G., Lenoir, F. et al. Logopenic syndrome in posterior cortical atrophy. J Neurol 260, 528–533 (2013). https://doi.org/10.1007/s00415-012-6671-7
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DOI: https://doi.org/10.1007/s00415-012-6671-7