Skip to main content

Advertisement

SpringerLink
Log in

Drug-induced impulse control disorders in Parkinson’s disease

  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Dopamine replacement treatment with excessive or aberrant dopamine receptor stimulation can cause behavioral disturbances in Parkinson’s disease, comprising dopamine dysregulation syndrome, punding, and impulse control disorders. Common impulse control disorders are compulsive buying, pathological gambling, binge eating, hypersexuality, and compulsive reckless driving.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Antonini A, Cilia R (2009) Behavioural adverse effects of dopaminergic treatments in Parkinson’s disease: incidence, neurobiological basis, management and prevention. Drug Saf 32:475–488

    Article  PubMed  CAS  Google Scholar 

  2. American Psychiatric Association (2000) APA diagnostic and statistical manual of mental disorders, 4th edn text revision. American Psychiatric Association, Washington, DC

  3. Ardouin C, Voon V, Worbe Y, Abouazar N, Czernecki V, Hosseini H, Pelissolo A, Moro E, Lhommee E, Lang AE, Agid Y, Benabid AL, Pollak P, Mallet L, Krack P (2006) Pathological gambling in Parkinson’s disease improves on chronic subthalamic nucleus stimulation. Mov Disord 21:1941–1946

    Article  PubMed  Google Scholar 

  4. Avanzi M, Baratti M, Cabrini S, Uber E, Brighetti G, Bonfa F (2006) Prevalence of pathological gambling in patients with Parkinson’s disease. Mov Disord 21:2068–2072

    Article  PubMed  Google Scholar 

  5. Avanzi M, Baratti M, Cabrini S, Uber E, Brighetti G, Bonfa F (2008) The thrill of reckless driving in patients with Parkinson’s disease: an additional behavioural phenomenon in dopamine dysregulation syndrome? Parkinsonism Relat Disord 14:257–258

    Article  PubMed  Google Scholar 

  6. Bostwick JM, Hecksel KA, Stevens SR, Bower JH, Ahlskog JE (2009) Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease. Mayo Clin Proc 84:310–316

    Article  PubMed  CAS  Google Scholar 

  7. Cilia R, Siri C, Marotta G, Isaias IU, De Gaspari D, Canesi M, Pezzoli G, Antonini A (2008) Functional abnormalities underlying pathological gambling in Parkinson disease. Arch Neurol 65:1604–1611

    Article  PubMed  Google Scholar 

  8. Cools R, Barker RA, Sahakian BJ, Robbins TW (2003) L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson’s disease. Neuropsychologia 41:1431–1441

    Article  PubMed  Google Scholar 

  9. Cools R, Lewis SJ, Clark L, Barker RA, Robbins TW (2007) L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson’s disease. Neuropsychopharmacology 32:180–189

    Article  PubMed  CAS  Google Scholar 

  10. Czernecki V, Pillon B, Houeto JL, Pochon JB, Levy R, Dubois B (2002) Motivation, reward, and Parkinson’s disease: influence of dopatherapy. Neuropsychologia 40:2257–2267

    Article  PubMed  CAS  Google Scholar 

  11. Dagher A, Robbins TW (2009) Personality, addiction, dopamine: insights from Parkinson’s disease. Neuron 61:502–510

    Article  PubMed  CAS  Google Scholar 

  12. Dewey RB Jr (2010) Pathological gambling in PD: did the devil make me do it? Neurology 75:1668–1669

    Article  PubMed  Google Scholar 

  13. Dodd ML, Klos KJ, Bower JH, Geda YE, Josephs KA, Ahlskog JE (2005) Pathological gambling caused by drugs used to treat Parkinson disease. Arch Neurol 62:1377–1381

    Article  PubMed  Google Scholar 

  14. Evans AH, Butzkueven H (2007) Dopamine agonist-induced pathological gambling in restless legs syndrome due to multiple sclerosis. Mov Disord 22:590–591

    Article  PubMed  Google Scholar 

  15. Evans AH, Lawrence AD, Potts J, Appel S, Lees AJ (2005) Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease. Neurology 65:1570–1574

    Article  PubMed  CAS  Google Scholar 

  16. Evans AH, Pavese N, Lawrence AD, Tai YF, Appel S, Doder M, Brooks DJ, Lees AJ, Piccini P (2006) Compulsive drug use linked to sensitized ventral striatal dopamine transmission. Ann Neurol 59:852–858

    Article  PubMed  CAS  Google Scholar 

  17. Evans AH, Strafella AP, Weintraub D, Stacy M (2009) Impulsive and compulsive behaviors in Parkinson’s disease. Mov Disord 24:1561–1570

    Article  PubMed  Google Scholar 

  18. Frank MJ, Seeberger LC, O’Reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306:1940–1943

    Article  PubMed  CAS  Google Scholar 

  19. Gallagher DA, O’Sullivan SS, Evans AH, Lees AJ, Schrag A (2007) Pathological gambling in Parkinson’s disease: risk factors and differences from dopamine dysregulation. An analysis of published case series. Mov Disord 22:1757–1763

    Article  PubMed  Google Scholar 

  20. Giovannoni G, O’Sullivan JD, Turner K, Manson AJ, Lees AJ (2000) Hedonistic homeostatic dysregulation in patients with Parkinson’s disease on dopamine replacement therapies. J Neurol Neurosurg Psychiatry 68:423–428

    Article  PubMed  CAS  Google Scholar 

  21. Goerendt IK, Lawrence AD, Brooks DJ (2004) Reward processing in health and Parkinson’s disease: neural organization and reorganization. Cereb Cortex 14:73–80

    Article  PubMed  Google Scholar 

  22. Grace AA (2000) The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 95 (Suppl 2):S119–S128

    Google Scholar 

  23. Grant JE, Levine L, Kim D, Potenza MN (2005) Impulse control disorders in adult psychiatric inpatients. Am J Psychiatry 162:2184–2188

    Article  PubMed  Google Scholar 

  24. Hariri AR, Brown SM, Williamson DE, Flory JD, de Wit H, Manuck SB (2006) Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J Neurosci 26:13213–13217

    Article  PubMed  CAS  Google Scholar 

  25. Isaias IU, Siri C, Cilia R, De Gaspari D, Pezzoli G, Antonini A (2008) The relationship between impulsivity and impulse control disorders in Parkinson’s disease. Mov Disord 23:411–415

    Article  PubMed  Google Scholar 

  26. Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403–1413

    Article  PubMed  Google Scholar 

  27. Kunig G, Leenders KL, Martin-Solch C, Missimer J, Magyar S, Schultz W (2000) Reduced reward processing in the brains of parkinsonian patients. Neuroreport 11:3681–3687

    Article  PubMed  CAS  Google Scholar 

  28. Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 27:1027–1035

    Article  PubMed  CAS  Google Scholar 

  29. Lim SY, O’Sullivan SS, Kotschet K, Gallagher DA, Lacey C, Lawrence AD, Lees AJ, O’Sullivan DJ, Peppard RF, Rodrigues JP, Schrag A, Silberstein P, Tisch S, Evans AH (2009) Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson’s disease. J Clin Neurosci 16:1148–1152

    Article  PubMed  CAS  Google Scholar 

  30. Lu C, Bharmal A, Suchowersky O (2006) Gambling and Parkinson disease. Arch Neurol 63:298

    Article  PubMed  Google Scholar 

  31. Mamikonyan E, Siderowf AD, Duda JE, Potenza MN, Horn S, Stern MB, Weintraub D (2008) Long-term follow-up of impulse control disorders in Parkinson’s disease. Mov Disord 23:75–80

    Article  PubMed  Google Scholar 

  32. O’Sullivan SS, Evans AH, Lees AJ (2009) Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management. CNS Drugs 23:157–170

    Article  PubMed  Google Scholar 

  33. Pontone G, Williams JR, Bassett SS, Marsh L (2006) Clinical features associated with impulse control disorders in Parkinson disease. Neurology 67:1258–1261

    Article  PubMed  Google Scholar 

  34. Ray N, Strafella AP (2010) Dopamine, reward, and frontostriatal circuitry in impulse control disorders in Parkinson’s disease: insights from functional imaging. Clin EEG Neurosci 41:87–93

    PubMed  Google Scholar 

  35. Rylander G (1972) Psychoses and the punding and choreiform syndromes in addiction to central stimulant drugs. Psychiatr Neurol Neurochir 75:203–212

    PubMed  CAS  Google Scholar 

  36. Shaffer HJ, Hall MN, Vander Bilt J (1999) Estimating the prevalence of disordered gambling behavior in the United States and Canada: a research synthesis. Am J Public Health 89:1369–1376

    Article  PubMed  CAS  Google Scholar 

  37. Siri C, Cilia R, De Gaspari D, Canesi M, Meucci N, Zecchinelli AL, Pezzoli G, Antonini A (2010) Cognitive status of patients with Parkinson’s disease and pathological gambling. J Neurol 257:247–252

    Article  PubMed  Google Scholar 

  38. Steeves TD, Miyasaki J, Zurowski M, Lang AE, Pellecchia G, Van Eimeren T, Rusjan P, Houle S, Strafella AP (2009) Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C]raclopride PET study. Brain 132:1376–1385

    Article  PubMed  CAS  Google Scholar 

  39. Thomas A, Bonanni L, Gambi F, Di Iorio A, Onofrj M (2010) Pathological gambling in Parkinson disease is reduced by amantadine. Ann Neurol 68:400–404

    Article  PubMed  Google Scholar 

  40. Tippmann-Peikert M, Park JG, Boeve BF, Shepard JW, Silber MH (2007) Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists. Neurology 68:301–303

    Article  PubMed  CAS  Google Scholar 

  41. van Eimeren T, Pellecchia G, Cilia R, Ballanger B, Steeves TD, Houle S, Miyasaki JM, Zurowski M, Lang AE, Strafella AP (2010) Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD. Neurology 75:1711–1716

    Article  PubMed  Google Scholar 

  42. Verbaan D, van Rooden SM, Visser M, Marinus J, Emre M, van Hilten JJ (2009) Psychotic and compulsive symptoms in Parkinson’s disease. Mov Disord 24:738–744

    Article  PubMed  Google Scholar 

  43. Voon V, Hassan K, Zurowski M, de Souza M, Thomsen T, Fox S, Lang AE, Miyasaki J (2006) Prevalence of repetitive and reward-seeking behaviors in Parkinson disease. Neurology 67:1254–1257

    Article  PubMed  CAS  Google Scholar 

  44. Voon V, Thomsen T, Miyasaki JM, de Souza M, Shafro A, Fox SH, Duff-Canning S, Lang AE, Zurowski M (2007) Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease. Arch Neurol 64:212–216

    Article  PubMed  Google Scholar 

  45. Weintraub D, Hoops S, Shea JA, Lyons KE, Pahwa R, Driver-Dunckley ED, Adler CH, Potenza MN, Miyasaki J, Siderowf AD, Duda JE, Hurtig HI, Colcher A, Horn SS, Stern MB, Voon V (2009) Validation of the questionnaire for impulsive-compulsive disorders in Parkinson’s disease. Mov Disord 24:1461–1467

    Article  PubMed  Google Scholar 

  46. Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, Voon V, Whetteckey J, Wunderlich GR, Lang AE (2010) Impulse control disorders in Parkinson disease: a cross-sectional study of 3,090 patients. Arch Neurol 67:589–595

    Article  PubMed  Google Scholar 

  47. Wolters E, van der Werf YD, van den Heuvel OA (2008) Parkinson’s disease-related disorders in the impulsive-compulsive spectrum. J Neurol 255(5):48–56

    Article  PubMed  Google Scholar 

  48. Wu K, Politis M, Piccini P (2009) Parkinson disease and impulse control disorders: a review of clinical features, pathophysiology and management. Postgrad Med J 85:590–596

    Article  PubMed  CAS  Google Scholar 

  49. Zesiewicz TA, Sullivan KL, Arnulf I, Chaudhuri KR, Morgan JC, Gronseth GS, Miyasaki J, Iverson DJ, Weiner WJ (2010) Practice Parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 74:924–931

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank S. Davis for her assistance in preparing the manuscript.

Conflict of interest

The authors have no conflict of interests to declare that are directly relevant to the content of this manuscript. W.H.J. is a lecturer and counselor to the companies Boehringer Ingelheim, GlaxoSmithKline, and UCB.

Author information

Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, HSK Wiesbaden, Ludwig-Erhard-Strasse 100, 65199, Wiesbaden, Germany

    J. Reiff

  2. Department of Neurology, Deutsche Klinik für Diagnostik, Aukammallee 33, 65191, Wiesbaden, Germany

    W. H. Jost

Authors
  1. J. Reiff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. H. Jost
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to W. H. Jost.

Additional information

This article is part of a supplement sponsored by GlaxoSmithKline.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reiff, J., Jost, W.H. Drug-induced impulse control disorders in Parkinson’s disease. J Neurol 258 (Suppl 2), 323–327 (2011). https://doi.org/10.1007/s00415-011-5932-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-011-5932-1

Keywords

Search

Navigation