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An fMRI study of musicians with focal dystonia during tapping tasks

Journal of Neurology volume 257, pages 1092–1098 (2010)Cite this article

Abstract

Musician’s dystonia is a type of task specific dystonia for which the pathophysiology is not clear. In this study, we performed functional magnetic resonance imaging to investigate the motor-related brain activity associated with musician’s dystonia. We compared brain activities measured from subjects with focal hand dystonia and normal (control) musicians during right-hand, left-hand, and both-hands tapping tasks. We found activations in the thalamus and the basal ganglia during the tapping tasks in the control group but not in the dystonia group. For both groups, we detected significant activations in the contralateral sensorimotor areas, including the premotor area and cerebellum, during each tapping task. Moreover, direct comparison between the dystonia and control groups showed that the dystonia group had greater activity in the ipsilateral premotor area during the right-hand tapping task and less activity in the left cerebellum during the both-hands tapping task. Thus, the dystonic musicians showed irregular activation patterns in the motor-association system. We suggest that irregular neural activity patterns in dystonic subjects reflect dystonic neural malfunction and consequent compensatory activity to maintain appropriate voluntary movements.

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References

  1. Begliomini C, Nelini C, Caria A, Grodd W, Castiello U (2008) Cortical activations in humans grasp-related areas depend on hand used and handedness. Plos One 3:1–9

    Article  CAS  Google Scholar 

  2. Berardelli A, Rothwell JC, Hallett M, Thompson PD, Manfredi M, Marsden CD (1998) The pathophysiology of primary dystonia. Brain 121:1195–1212

    Article  PubMed  Google Scholar 

  3. Blakemore SJ, Frith CD, Wolpert DM (2001) The cerebellum is involved in predicting the sensory consequences of action. Neuroreport 12:1879–1884

    Article  CAS  PubMed  Google Scholar 

  4. Ceballos-Baumann AO, Sheean G, Passingham RE, Marsden CD, Brooks DJ (1997) Botulinum toxin does not reverse the cortical dysfunction associated with writer’s cramp. A PET study. Brain 120:571–582

    Article  PubMed  Google Scholar 

  5. Elbert T, Candia V, Altenmüller E, Rau H, Sterr A, Rockstroh B, Pantev C, Taub E (1998) Alteration of digital representations in somatosensory cortex in focal hand dystonia. Neuroreport 9:3571–3575

    Article  CAS  PubMed  Google Scholar 

  6. Gilio F, Curra A, Inghilleri M, Lorenzano C, Suppa A, Manfredi M, Berardelli A (2003) Abnormalities of motor cortex excitability preceding movement in patients with dystonia. Brain 126:1745–1754

    Article  CAS  PubMed  Google Scholar 

  7. Hallett M (1998) Physiology of dystonia. Adv Neurol 78:11–18

    CAS  PubMed  Google Scholar 

  8. Haslinger B, Erhard P, Dresel C, Castrop F, Roettinger M, Ceballos-Baumann AO (2005) “Silent event-related fMRI” reveals reduced sensorimotor activation in laryngeal dystonia. Neurology 65:1562–1569

    Article  CAS  PubMed  Google Scholar 

  9. Ibáñez V, Sadato N, Karp B, Deiber MP, Hallett M (1999) Deficient activation of the motor cortical network in patients with writer’s cramp. Neurology 53:96–105

    PubMed  Google Scholar 

  10. Lerner A, Shill H, Hanakawa T, Bushara K, Goldfine A, Hallett M (2004) Regional cerebral blood flow correlates of the severity of writer’s cramp symptoms. Neuroimage 21:904–913

    Article  PubMed  Google Scholar 

  11. Lim VK, Altenmüller E, Bradshaw JL (2001) Focal dystonia: current theories. Hum Mov Sci 20:875–914

    Article  CAS  PubMed  Google Scholar 

  12. Munte TF, Altenmüller E, Jancke L (2002) The musician’s brain as a model of neuroplasticity. Nat Rev Neurosci 3:473–478

    Article  PubMed  CAS  Google Scholar 

  13. Murase N, Rothwell JC, Kaji R, Urushihara R, Nakamura K, Murayama N, Igasaki T, Sakata-Igasaki M, Mima T, Ikeda A, Shibasaki H (2005) Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer’s cramp. Brain 128:104–115

    Article  PubMed  Google Scholar 

  14. Nishimura Y, Onoe H, Morichika Y, Perfiliev S, Tsukada H, Isa T (2007) Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury. Science 318:1150–1155

    Article  CAS  PubMed  Google Scholar 

  15. Oga T, Honda M, Toma K, Murase N, Okada T, Hanakawa T, Sawamoto N, Nagamine T, Konishi J, Fukuyama H, Kaji R, Shibasaki H (2002) Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer’s cramp: an fMRI study. Brain 125:895–903

    Article  CAS  PubMed  Google Scholar 

  16. Pascual-Leone A (2001) The brain that plays music and is changed by it. Ann N Y Acad Sci 930:315–329

    Article  CAS  PubMed  Google Scholar 

  17. Porter R, Lemon R (1993) Motor functions of non-primary cortical motor areas. In: Porter R, Lemon R (eds) Cortical function and voluntary movement. Clarendon Press, Oxford, pp 273–303

    Google Scholar 

  18. Preibisch C, Berg D, Hofmann E, Solymosi L, Naumann M (2001) Cerebral activation patterns in patients with writer’s cramp: a functional magnetic resonance imaging study. J Neurol 248:10–17

    Article  CAS  PubMed  Google Scholar 

  19. Pujol J, Roset-Llobet J, Rosines-Cubells D, Deus J, Narberhaus B, Valls-Sole J, Capdevila A, Pascual-Leone A (2000) Brain cortical activation during guitar-induced hand dystonia studied by functional MRI. Neuroimage 12:257–267

    Article  CAS  PubMed  Google Scholar 

  20. Pullman SL, Hristova AH (2005) Musician’s dystonia. Neurology 64:186–187

    PubMed  Google Scholar 

  21. Quartarone A, Bagnato S, Rizzo V, Siebner HR, Dattola V, Scalfari A, Morgante F, Battaglia F, Romano M, Girlanda P (2003) Abnormal associative plasticity of the human motor cortex in writer’s cramp. Brain 126:2586–2596

    Article  PubMed  Google Scholar 

  22. Rosenkranz K, Williamon A, Butler K, Cordivari C, Lees AJ, Rothwell JC (2005) Pathophysiological differences between musician’s dystonia and writer’s cramp. Brain 128:918–931

    Article  PubMed  Google Scholar 

  23. Siebner HR, Filipovic SR, Rowe JB, Cordivari C, Gerschlager W, Rothwell JC, Frackowiak RS, Bhatia KP (2003) Patients with focal arm dystonia have increased sensitivity to slow-frequency repetitive TMS of the dorsal premotor cortex. Brain 126:2710–2725

    Article  PubMed  Google Scholar 

  24. Talairach J, Tournoux P (1988) Co-planar stereotactic atlas of the human brain: Three-dimensional proportional system: an approach to cerebral imaging. George Thieme Verlag, Stuttgart

    Google Scholar 

  25. Torres-Russotto D, Perlmutter JS (2008) Task-specific dystonias: a review. Ann N Y Acad Sci 1142:179–199

    Article  PubMed  Google Scholar 

  26. Xing-yue H, Li W, Hai L, Shi-Zheng Z (2006) Functional magnetic resonance imaging study of writer’s cramp. Chin Med J 119:1263–1271

    Google Scholar 

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Acknowledgment

This study was partly supported by the YAMAHA Music Foundation. We wish to thank Prof. Emer. Juntendo University Dr. Yasuo Yamauchi for helpful comments and encouragement.

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Author notes

  1. Hiroshi Kadota

    Present address: Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

Authors and Affiliations

  1. Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama, 359-8555, Japan

    Hiroshi Kadota, Yasoichi Nakajima, Makoto Miyazaki, Hirofumi Sekiguchi & Yutaka Kohno

  2. Course of Functional Control Systems, Graduate School of Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama, Satitama, 337-8570, Japan

    Hiroshi Kadota

  3. Research Institute, Kochi University of Technology, 185 Miyanokuchi, Tosayamada, Kochi, 782-8502, Japan

    Makoto Miyazaki

  4. Faculty of Business and Information Sciences, Jobu University, 634-1, Toyatsuka-machi, Isesaki, Gunma, 372-8588, Japan

    Hirofumi Sekiguchi

  5. Ibaraki Prefectural University of Health Sciences, 4733 Ami, Ami-machi, Inashiki, Ibaraki, 300-0331, Japan

    Yutaka Kohno

  6. Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Masatoshi Amako, Hiroshi Arino & Koichi Nemoto

  7. National Defense Medical College Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan

    Koichi Nemoto

  8. Department of Mechanical and Intelligent Engineering, Graduate School of Engineering, Utsunomiya University, 7-1-2 Yoto, Utsunomiya, 321-8585, Japan

    Naotaka Sakai

  9. Department of Orthopedic Surgery, School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan

    Naotaka Sakai

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  1. Hiroshi Kadota
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  2. Yasoichi Nakajima
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  3. Makoto Miyazaki
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  4. Hirofumi Sekiguchi
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  6. Masatoshi Amako
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  7. Hiroshi Arino
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  9. Naotaka Sakai
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Correspondence to Hiroshi Kadota.

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Kadota, H., Nakajima, Y., Miyazaki, M. et al. An fMRI study of musicians with focal dystonia during tapping tasks. J Neurol 257, 1092–1098 (2010). https://doi.org/10.1007/s00415-010-5468-9

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  • DOI: https://doi.org/10.1007/s00415-010-5468-9

Keywords

  • Functional magnetic resonance imaging
  • Musician
  • Dystonia
  • Premotor cortex