Skip to main content
Log in

Intra-cerebral haemorrhages: are there any differences in baseline characteristics and intra-hospital mortality between hospitaland population-based registries?

Journal of Neurology Aims and scope Submit manuscript

Abstract

A better understanding of the natural history of intracerebral haemorrhages (ICH) with cohorts representing the whole spectrum of the disease is necessary to improve treatment. Our aim was to identify potential differences in baseline characteristics and short-term outcomes of patients with non-traumatic ICH, included in a hospital- and in a population-based stroke registry.

We compared 373 patients recruited in a university hospital and the last 373 ICH patients included in a population-based registry. Both cohorts included consecutive patients with non-traumatic parenchymal haemorrhages. In the hospital cohort, we collected data from all patients admitted in the emergency room, irrespective of the clinical severity and of the specialist in charge of the patient.

In the hospital cohort, patients were younger and more often alcoholic, but these differences may be explained by the younger age and a higher prevalence of alcoholism in this area. Patients also had more frequently hypercholesterolemia, and were more often under antiplatelet therapy. Both cohorts did not differ for intra-hospital casefatality rate.

The characteristics of patients included in the hospital cohort were very close to those of patients from a population-based registry, and the differences observed are likely to be explained by differences in the characteristics of the populations in the two areas and different periods of recruitment. Recruiting patients in emergency rooms, and not in stroke units, neurological, or neurosurgical departments, has enabled us to build a cohort of ICH patients representative of the whole spectrum of the disease, with minimised recruitment bias and maximised precision of the variables collected. This cohort may, therefore, provide reliable information on the natural history of ICH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C (1990) A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project – 1981–86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 53:16–22

    Article  PubMed  CAS  Google Scholar 

  2. Benatru I, Rouaud O, Durier J, Contegal F, Couvreur G, Bejot Y, Osseby GV, Ben Salem D, Ricolfi F, Moreau T, Giroud M (2006) Stable stroke incidence rates but improved case-fatality in Dijon, France, from 1985 to 2004. Stroke 37:1674–1679

    Article  PubMed  Google Scholar 

  3. Cordonnier C, Girot M, Dorp E, Rimetz P, Bouillaguet S, Hénon H, Lucas C, Godefroy O, Leys D (2000) Stroke Units from scientific evidence to practice: The experience of the Lille Stroke Unit. Cerebrovasc Dis 10:17–20

    Article  PubMed  Google Scholar 

  4. EUROASPIRE I and II group (2001) Clinical reality of coronary prevention guidelines: a comparison of EUROASPIRE I and II in nine countries. EUROASPIRE I and II Group. European Action on Secondary Prevention by Intervention to Reduce Events. Lancet 357:995–1001

    Google Scholar 

  5. Garibi J, Bilbao G, Pomposo I, Hostalot C (2002) Prognostic factors in a series of 185 consecutive spontaneous supratentorial intracerebral haematomas. Br J Neurosurg 16:355–361

    Article  PubMed  CAS  Google Scholar 

  6. Girot M, Mackowiak-Cordoliani MA, Deplanque D, Henon H, Lucas C, Leys D (2005) Secondary prevention after ischemic stroke. Evolution over time in practice. J Neurol 252:14–20

    Article  PubMed  Google Scholar 

  7. Giroud M, Beuriat P, Vion P, D’Athis P, Dusserre L, Dumas R (1989) Cerebral vascular complications in the population of Dijon. Incidence-breakdownmortality. Rev Neurol (Paris) 145:221–227

    PubMed  CAS  Google Scholar 

  8. Giroud M, Lemesle M, Quantin C, Vourch M, Becker F, Milan C, Brunet- Lecomte P, Dumas R (1997) A hospitalbased and a population-based stroke registry yield different results: the experience in Dijon, France. Neuroepidemiology 16:15–21

    Article  PubMed  CAS  Google Scholar 

  9. Giroud M, Milan C, Beuriat P, Gras P, Essayagh E, Arveux P, Dumas R (1991) Incidence and survival rates during a two-year period of intracerebral and subarachnoid haemorrhages, cortical infarcts, lacunes and transient ischaemic attacks. The Stroke Registry of Dijon: 1985–1989. Int J Epidemiol 20: 892–899

    Article  PubMed  CAS  Google Scholar 

  10. http://www.orsnpdc.org/donnees/ 134029_1toutes-c.htm

  11. http://www.orsnpdc.org/donnees/ 134047_1tumeurs.htm

  12. http://www.orsnpdc.org/etudes/132158_ 100-10.pdf

  13. http://www.recensement.insee.fr/RP99/ rp99/wr_page.affiche?p_id_ transac=&p_theme=POP&p_ typeprod=ALL&p_id_nivgeo=P&p_id_ loca=2199&p_id_princ=POP1&p_id_ second=POP1A&p_langue=FR&p_ specim=N&p_pourcent=3

  14. http://www.recensement.insee.fr/RP99/ rp99/wr_page.affiche?p_id_ transac=&p_theme=POP&p_ typeprod=ALL&p_id_nivgeo=P&p_id_ loca=5992&p_id_princ=POP1&p_id_ second=POP1A&p_langue=FR&p_ specim=N&p_pourcent=2

  15. Lang T, Ducimetiere P, Arveiler D, Amouyel P, Ferrieres J, Ruidavets JB, Montaye M, Haas B, Bingham A (1999) Trends and geographical disparities in coronary heart disease in France: are results concordant when different definitions of events are used? Int J Epidemiol 28:1050–1058

    Article  PubMed  CAS  Google Scholar 

  16. Leira R, Davalos A, Silva Y, Gil-Peralta A, Tejada J, Garcia M, Castillo J (2004) Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors. Neurology 63:461–467

    PubMed  CAS  Google Scholar 

  17. Lyden PD, Shuaib A, Lees KR, Davalos A, Davis SM, Diener HC, Grotta JC, Ashwood TJ, Hardemark HG, Svensson HH, Rodichok L, Wasiewski WW, Ahlberg G (2007) Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial. Stroke 38:2262–2269

    Article  PubMed  CAS  Google Scholar 

  18. Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T (2005) Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 352:777–785

    Article  PubMed  CAS  Google Scholar 

  19. Mendelow AD, Gregson BA, Fernandes HM, Murray GD, Teasdale GM, Hope DT, Karimi A, Shaw MD, Barer DH (2005) Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet 365:387–397

    PubMed  Google Scholar 

  20. Roch A, Michelet P, Jullien AC, Thirion X, Bregeon F, Papazian L, Roche P, Pellet W, Auffray JP (2003) Long-term outcome in intensive care unit survivors after mechanical ventilation for intracerebral hemorrhage. Crit Care Med 31:2651–2656

    Article  PubMed  Google Scholar 

  21. Rothwell PM, Coull AJ, Giles MF, Howard SC, Silver LE, Bull LM, Gutnikov SA, Edwards P, Mant D, Sackley CM, Farmer A, Sandercock PA, Dennis MS, Warlow CP, Bamford JM, Anslow P (2004) Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 363:1925–1933

    Article  PubMed  CAS  Google Scholar 

  22. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to C. Cordonnier MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cordonnier, C., Rutgers, M.P., Dumont, F. et al. Intra-cerebral haemorrhages: are there any differences in baseline characteristics and intra-hospital mortality between hospitaland population-based registries?. J Neurol 256, 198–202 (2009). https://doi.org/10.1007/s00415-009-0030-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-009-0030-3

Key words

Navigation