Journal of Neurology

, Volume 255, Issue 8, pp 1121–1126 | Cite as

The association between smoking and smell and taste impairment in the general population

  • M. M. VennemannEmail author
  • T. Hummel
  • K. Berger
Original Communication



The aim of this study was to evaluate the effect of smoking on taste and smell impairment in a large population- based study.

Study design

Cross-sectional survey in Dortmund, Germany.


The population sample was randomly drawn from the city’s central registration office. Following a standardized interview, validated taste and smell tests were performed. Descriptive statistics and logistic regression was used in the analysis.


Among the 1312 study participants, 3.6 % were functionally anosmic, and 18 % had olfactory dysfunction. Approximately 20 % recognized only three or less of the four tastes when presented at suprathreshold concentrations, indicating signs of taste impairment. Current smoking in general increased the risk for impairment of olfactory function (odds ratio 1.71, 95 % CI 1.19–2.47), but not the risk for taste impairment. Heavy smokers of 20 or more cigarettes/day had significant increased risks for impairment in both senses.


Our results reveal that both olfactory and gustatory function are compromised in a significant proportion of the general population. Smoking increases significantly the risk of impairment of olfactory function. Our findings add an important detail to the large body of evidence that describes adverse health effects of smoking.

Key words

odor olfaction gustation aging population studies risk factors 


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  1. 1.
    Damm M, Temmel A, Welge-Lussen A, Eckel HE, Kreft MP, Klussmann JP, et al. (2004) Riechstörungen – Epidemiologie und Therapie in Deutschland, Österreich und der Schweiz. HNO 52(2):112–120PubMedCrossRefGoogle Scholar
  2. 2.
    Landis BN, Hummel T (2006) New evidence for high occurrence of olfactory dysfunctions within the population. Am J Med 119(1):91–92PubMedCrossRefGoogle Scholar
  3. 3.
    Santos DV, Reiter ER, DiNardo LJ, Costanzo RM (2004) Hazardous events associated with impaired olfactory function. Arch Otolaryngol Head Neck Surg 130(3):317–319PubMedCrossRefGoogle Scholar
  4. 4.
    Deems DA, Doty RL, Settle RG, Moore- Gillon V, Shaman P, Mester AF, et al. (1991) Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 117(5):519–528PubMedGoogle Scholar
  5. 5.
    Miwa T, Furukawa M, Tsukatani T, Costanzo RM, DiNardo LJ, Reiter ER (2001) Impact of olfactory impairment on quality of life and disability. Arch Otolaryngol Head Neck Surg 127(5):497–503PubMedGoogle Scholar
  6. 6.
    Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128(6):635–641PubMedGoogle Scholar
  7. 7.
    Hummel T, Nordin S (2005) Olfactory disorders and their consequences for quality of life. Acta Otolaryngol 125(2):116–121PubMedCrossRefGoogle Scholar
  8. 8.
    Bramerson A, Johansson L, Ek L, Nordin S, Bende M (2004) Prevalence of olfactory dysfunction: the skovde population-based study. Laryngoscope 114(4):733–737PubMedCrossRefGoogle Scholar
  9. 9.
    Hoffman HJ, Ishii EK, MacTurk RH (1998) Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci 855:716–722PubMedCrossRefGoogle Scholar
  10. 10.
    Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114(10):1764–1769PubMedCrossRefGoogle Scholar
  11. 11.
    Wysocki CJ, Gilbert AN (1989) National Geographic Smell Survey. Effects of age are heterogenous. Ann N Y Acad Sci 561:12–28PubMedCrossRefGoogle Scholar
  12. 12.
    Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L (1984) Smell identification ability: changes with age. Science 226(4681):1441–1443PubMedCrossRefGoogle Scholar
  13. 13.
    Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM (2002) Prevalence of olfactory impairment in older adults. JAMA 288(18):2307–2312PubMedCrossRefGoogle Scholar
  14. 14.
    Leopold DA, Bartels S (2002) Evaluation of olfaction. J Otolaryngol 31 (Suppl 1):S18–S23PubMedCrossRefGoogle Scholar
  15. 15.
    Ponsen MM, Stoffers D, Booij J, Eck- Smit BL, Wolters EC, Berendse HW (2004) Idiopathic hyposmia as a preclinical sign of Parkinson’s disease. Ann Neurol 56(2):173–181PubMedCrossRefGoogle Scholar
  16. 16.
    Haehner A, Hummel T, Hummel C, Sommer U, Junghanns S, Reichmann H (2007) Olfactory loss may be a first sign of idiopathic Parkinson’s disease. Mov Disord 22(6):839–842PubMedCrossRefGoogle Scholar
  17. 17.
    Bacon AW, Bondi MW, Salmon DP, Murphy C (1998) Very early changes in olfactory functioning due to Alzheimer’s disease and the role of apolipoprotein E in olfaction. Ann N Y Acad Sci 855:723–731PubMedCrossRefGoogle Scholar
  18. 18.
    Murphy C (1999) Loss of olfactory function in dementing disease. Physiol Behav 66(2):177–182PubMedCrossRefGoogle Scholar
  19. 19.
    Fortier I, Ferraris J, Mergler D (1991) Measurement precision of an olfactory perception threshold test for use in field studies. Am J Ind Med 20(4):495–504PubMedCrossRefGoogle Scholar
  20. 20.
    McLean D, Feron F, Mackay-Sim A, McCurdy R, Hirning M, Chant D, et al. (2004) Paradoxical association between smoking and olfactory identification in psychosis versus controls. Aust N Z J Psychiatry 38(1–2):81–83PubMedCrossRefGoogle Scholar
  21. 21.
    Frye RE, Schwartz BS, Doty RL (1990) Dose-related effects of cigarette smoking on olfactory function. JAMA 263(9):1233–1236PubMedCrossRefGoogle Scholar
  22. 22.
    Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, et al. (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257(4):205–211PubMedCrossRefGoogle Scholar
  23. 23.
    Hummel T, Konnerth CG, Rosenheim K, Kobal G (2001) Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss. Ann Otol Rhinol Laryngol 110(10):976–981PubMedGoogle Scholar
  24. 24.
    Keil U, Liese AD, Hense HW, Filipiak B, Doring A, Stieber J, et al. (1998) Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany. Results from the MONICA Augsburg cohort study 1984–1992. Monitoring Trends and Determinants in Cardiovascular Diseases. Eur Heart J 19(8):1197–1207PubMedCrossRefGoogle Scholar
  25. 25.
    Nordin S, Bramerson A, Bende M (2004) Prevalence of self-reported poor odor detection sensitivity: the Skovde population-based study. Acta Otolaryngol 124(10):1171–1173PubMedCrossRefGoogle Scholar
  26. 26.
    Mackay-Sim A, Grant L, Owen C, Chant D, Silburn P (2004) Australian norms for a quantitative olfactory function test. J Clin Neurosci 11(8):874–879PubMedCrossRefGoogle Scholar
  27. 27.
    Elsner RJ (2001) Odor threshold, recognition, discrimination and identification in centenarians. Arch Gerontol Geriatr 33(1):81–94PubMedCrossRefGoogle Scholar
  28. 28.
    Schiffman SS (1997) Taste and smell losses in normal aging and disease. JAMA 278(16):1357–1362PubMedCrossRefGoogle Scholar
  29. 29.
    Engen T, Bosack TN (1969) Facilitation in olfactory detection. J Comp Physiol Psychol 68(3):320–326PubMedCrossRefGoogle Scholar
  30. 30.
    Hudson R, Distel H (1998) Induced peripheral sensitivity in the developing vertebrate olfactory system. Ann N Y Acad Sci 855:109–115PubMedCrossRefGoogle Scholar
  31. 31.
    Moller R, Pause BM, Ferstl R (1999) Inducibility of olfactory sensitivity by odor exposure of persons with specific anosmia. Z Exp Psychol 46(1):53–59PubMedGoogle Scholar
  32. 32.
    Wang L, Chen L, Jacob T (2004) Evidence for peripheral plasticity in human odour response. J Physiol 554(Pt 1):236–244PubMedCrossRefGoogle Scholar
  33. 33.
    Pribitkin E, Rosenthal MD, Cowart BJ (2003) Prevalence and causes of severe taste loss in a chemosensory clinic population. Ann Otol Rhinol Laryngol 112(11):971–978PubMedGoogle Scholar
  34. 34.
    Heckmann JG, Heckmann SM, Lang CJ, Hummel T (2003) Neurological aspects of taste disorders. Arch Neurol 60(5):667–671PubMedCrossRefGoogle Scholar
  35. 35.
    Landis BN, Beutner D, Frasnelli J, Huttenbrink KB, Hummel T (2005) Gustatory function in chronic inflammatory middle ear diseases. Laryngoscope 115(6):1124–1127PubMedCrossRefGoogle Scholar
  36. 36.
    Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, et al. (2003) Quantitative assessment of gustatory function in a clinical context using impregnated “taste strips”. Rhinology 41(1):2–6PubMedGoogle Scholar
  37. 37.
    de Araujo IE, Rolls ET, Kringelbach ML, McGlone F, Phillips N (2003) Taste-olfactory convergence, and the representation of the pleasantness of flavour, in the human brain. Eur J Neurosci 18(7):2059–2068PubMedCrossRefGoogle Scholar
  38. 38.
    Welge-Lussen A, Drago J, Wolfensberger M, Hummel T (2005) Gustatory stimulation influences the processing of intranasal stimuli. Brain Res 1038(1):69–75PubMedCrossRefGoogle Scholar
  39. 39.
    Amoore JE, Venstrom D, Davis AR (1968) Measurement of specific anosmia. Percept Mot Skills 26(1):143–164PubMedGoogle Scholar
  40. 40.
    Rosenblatt MR, Olmstead RE, Iwamoto- Schaap PN, Jarvik ME (1998) Olfactory thresholds for nicotine and menthol in smokers (abstinent and nonabstinent) and nonsmokers. Physiol Behav 65(3):575–579PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  1. 1.Institute of Epidemiology and Social MedicineUniversity of MünsterMünsterGermany
  2. 2.Smell & Taste Clinic, Dept. of OtorhinolaryngologyUniversity of Dresden Medical SchoolDresdenGermany
  3. 3.Institute of Legal MedicineUniversity of MünsterMuensterGermany

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