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Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A

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Abstract

Objective

To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin type A.

Methods

Short-term power spectral analysis of heart rate and systolic blood pressure variability, high-frequency and low-frequency oscillations of heart rate variability, low frequency/high frequency ratio and baroreflex sensitivity (α index) were measured in 12 patients with cervical dystonia before and 2–4 weeks after botulinum toxin type A injection and compared with normative data.

Results

Before treatment, at rest, patients had significantly lower high frequency power than healthy subjects (p < 0.01), whereas no differences were found in low frequency power. Botulinum toxin injection in patients induced no changes in either power frequency. In patients before treatment and healthy subjects the low frequency oscillatory components increased similarly from rest to tilt (p < 0.01), but tilt induced lower low frequency values in patients than in healthy subjects (p < 0.01). In patients before treatment, the high frequency variations from rest to tilt remained unchanged, whereas in healthy subjects they decreased significantly (p < 0.01). Botulinum toxin type A injection in patients induced no changes in low frequency or high frequency powers. In patients before treatment the low frequency/high frequency ratio increased slightly from rest to tilt, but in healthy subjects increased significantly (p < 0.01). Botulinum toxin type A left the pretreatment low frequency/high frequency ratio unchanged. The α-index measured at rest in patients before treatment was lower than in healthy subjects (p<0.05), whereas during tilt was similar in both groups. The α-index measured after botulinum toxin injection in patients remained unchanged at rest and during tilt.

Conclusions

Patients with cervical dystonia receiving treatment with botulinum toxin type A have mild, subclinical abnormalities in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity. These changes do not worsen after acute botulinum toxin type A injection.

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Authors and Affiliations

  1. Department of Neurological Sciences and Neuromed Institute (IRCCS), University of Rome “La Sapienza”, Viale dell’Università, 30, 00185, Roma, Italy

    D. Tiple, C. Colosimo, G. Fabbrini, M. Prencipe & A. Berardelli

  2. Department of Cardiovascular and Respiratory Sciences, University of Rome “La Sapienza”, 00185, Roma, Italy

    S. Strano

  3. Cardiovascular Bioengineering Unit, Department of Technologies and Health, Italian National Institute of Health, Rome, Italy

    G. Calcagnini

Authors
  1. D. Tiple
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  2. S. Strano
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  3. C. Colosimo
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  4. G. Fabbrini
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  5. G. Calcagnini
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  6. M. Prencipe
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  7. A. Berardelli
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Correspondence to A. Berardelli.

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Tiple, D., Strano, S., Colosimo, C. et al. Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A. J Neurol 255, 843–847 (2008). https://doi.org/10.1007/s00415-008-0753-6

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  • DOI: https://doi.org/10.1007/s00415-008-0753-6

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