Leber’s Hereditary Optic Neuropathy associated with cocaine, ecstasy and telithromycin consumption

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References

  1. 1.

    Newman NJ (2005) Hereditary optic neuropathies: from the mitochondria to the optic nerve. Am J Ophthalmol 140:517–523

    PubMed  CAS  Google Scholar 

  2. 2.

    Howell N (1998) Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve. Vision Res 38:1495–1504

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    Battisti C, Formichi P, Cardaioli E, et al. (2004) Cell response to oxidative stress induced apoptosis in patients with Leber’s hereditary optic neuropathy. J Neurol Neurosurg Psychiatry 75:1731–1736

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Zanna C, Ghelli A, Porcelli AM, Martinuzzi A, Carelli V, Rugolo M (2005) Caspase-independent death of Leber’s hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G. Apoptosis 10:997–1007

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Hudson G, Keers S, Yu Wai Man P, et al. (2005) Identification of an X_chromosomal locus and haplotype modulating the phenotype of a mitochondrial DNA disorder. Am J Hum Genet 77:1086–1091

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Shaikh S, Ta C, Basham AA, Mansour S (2001) Leber hereditary optic neuropathy associated with antiretroviral therapy for human immunodeficiency virus infection. Am J Ophthalmol 131:143–145

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Rufa A, Dotti MT, Cardaioli E, Da Pozzo P, Federico A (2005) Leber hereditary optic neuropathy in 2 of 4 siblings with 11778 mtDNA mutation: clinical variability or effect of toxic environmental exposure? Eur Neurol 53:32–4 [Published Online First: 10 February 2005]

    PubMed  Article  Google Scholar 

  8. 8.

    Kovacic P (2005) Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer. Med Hypotheses 64:350–356

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Zaragoza A, Diez-Fernandez C, Alvarez AM, Andres D, Cascales M (2001) Mitochondrial involvement in cocaine-treated rat hepatocytes: effect of N-acetylcysteine and deferoxamine. Br J Pharmacol 132:1063–1070

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Fosslien E (2001) Mitochondrial medicine–molecular pathology of defective oxidative phosphorylation. Ann Clin Lab Sci 31:25–67

    PubMed  CAS  Google Scholar 

  11. 11.

    Dietrich JB, Poirier R, Aunis D, Zwiller J (2004) Cocaine downregulates the expression of the mitochondrial genome in rat brain. Ann N Y Acad Sci 1025:345–350

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Deng X, Cadet JL (1999) Methamphetamine administration causes overexpression of nNOS in the mouse striatum. Brain Res 851:254–257

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Jimenez A, Jorda EG, Verdaguer E, et al. (2004) Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicol Appl Pharmacol 196:223–234

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Burrows KB, Nixdorf WL, Yamamoto BK (2000) Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines. J Pharmacol Exp Ther 292(3):853–860

    PubMed  CAS  Google Scholar 

  15. 15.

    Beretta S, Mattavelli L, Sala G, et al. (2004) Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines. Brain 127(Pt 10):2183–92 [Published Online First: 1 September 2004]

    PubMed  Article  Google Scholar 

  16. 16.

    Clay KD, Hanson JS, Pope SD, Rissmiller RW, Purdum PP 3rd, Banks PM (2006) Brief Communication: Severe Hepatotoxicity of Telithromycin: Three Case Reports and Literature Review. Ann Intern Med [Epub ahead of print]

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Acknowledgements

Research was partly supported by a grant from University of Siena and Regione Toscana to AF.

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Correspondence to Antonio Federico.

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Received in revised form: 3 July 2006

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Cardaioli, E., Da Pozzo, P., Gallus, G. et al. Leber’s Hereditary Optic Neuropathy associated with cocaine, ecstasy and telithromycin consumption. J Neurol 254, 255–256 (2007). https://doi.org/10.1007/s00415-006-0351-4

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Keywords

  • Cocaine
  • Ecstasy
  • Telithromycin
  • Increase Reactive Oxygen Species Production
  • Retinal Ganglion Cell