References
Crawford F, Freeman M, Abdullah L, Schinka J, Gold M, Duara R, Mullan M (2000) No association between the NOS3 codon 298 polymorphism and Alzheimer's disease in a sample from the United States. Ann Neurol 47:687
Dahiyat M, Cumming A, Harrington C, Wischik C, Xuereb J, Corrigan F, Breen G, Shaw D, St Clair D (1999) Association between Alzheimer's disease and the NOS3 gene. Ann Neurol 46:664–667
Emahazion T, Feuk L, Jobs M, Sawyer SL, Fredman D, St Clair D, Prince JA, Brookes AJ (2001) SNP association studies in Alzheimer's disease highlight problems for complex disease analysis. Trends Genet 17:407–413
Higuchi S, Ohta S, Matsushita S, Matsui T, Yuzuriha T, Urakami K, Arai H (2000) NOS3 polymorphism not associated with Alzheimer's disease in Japanese. Ann Neurol 48:685
Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos–Ioannidis DG (2001) Replication validity of genetic association studies. Nat Genet 29:306–309
Kalman J, Juhasz A, Rimanoczy A, Palotas A, Palotas M, Boda K, Marki– Zay J, Csibri E, Janka Z (2003) The nitric oxide synthase–3 codon 298 polymorphism is not associated with late–onset sporadic Alzheimer's dementia and Lewy body disease in a sample from Hungary. Psychiatr Genet 13:201–204
Kunugi H, Akahane A, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S (2000) No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease. J Neural Transm 107:1081–1084
Monastero R, Cefalu AB, Camarda C, Buglino CM, Mannino M, Barbagallo CM, Lopez G, Camarda LK, Travali S, Camarda R, Averna MR (2003) No association between Glu298Asp endothelial nitric oxide synthase polymorphism and Italian sporadic Alzheimer's disease. Neurosci Lett 341:229–232
Ntais C, Polycarpou A, Ioannidis JP (2004) Meta–analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE genedisease association review. Am J Epidemiol 159:527–536
Prince JA, Feuk L, Sawyer SL, Gottfries J, Ricksten A, Nagga K, Bogdanovic N, Blennow K, Brookes AJ (2001) Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur J Hum Genet 9:437–444
Sanchez–Guerra M, Combarros O, Alvarez–Arcaya A, Mateo I, Berciano J, Gonzalez–Garcia J, Llorca J (2001) The Glu298Asp polymorphism in the NOS3 gene is not associated with sporadic Alzheimer's disease. J Neurol Neurosurg Psychiatry 70:566–567
Singleton AB, Gibson AM, McKeith IG, Ballard CG, Edwardson JA, Morris CM (2001) Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies. Neurosci Lett 303:33–36
Styczynska M, Religa D, Pfeffer A, Luczywek E, Wasiak B, Styczynski G, Peplonska B, Gabryelewicz T, Golebiowski M, Kobrys M, Barcikowska M (2003) Simultaneous analysis of five genetic risk factors in Polish patients with Alzheimer's disease. Neurosci Lett 344:99–102
Tedde A, Nacmias B, Cellini E, Bagnoli S, Sorbi S (2002) Lack of association between NOS3 polymorphism and Italian sporadic and familial Alzheimer's disease. J Neurol 249:110–111
Wang QH, Zhang JW, Zhang ZX, Wu CB, Chen D (2004) Association between Alzheimer's disease and nitric oxide synthase III polymorphism. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:112–115
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Ntais, C., Polycarpou, A. Association of the endothelial nitric oxide synthase (NOS3) Glu298Asp gene polymorphism with the risk of Alzheimer's disease. J Neurol 252, 1276–1278 (2005). https://doi.org/10.1007/s00415-005-0823-y
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DOI: https://doi.org/10.1007/s00415-005-0823-y