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Déjà vu in neurology

Abstract

The significance of déjà vu is widely recognised in the context of temporal lobe epilepsy, and enquiry about déjà vu is frequently made in the clinical assessment of patients with possible epilepsy. Déjà vu has also been associated with several psychiatric disorders. The historical context of current understanding of déjà vu is discussed. The literature reveals déjà vu to be a common phenomenon consistent with normality. Several authors have suggested the existence of a “pathological” form of déjà vu that differs, qualitatively or quantitatively, from “non-pathological” déjà vu. The features of déjà vu suggesting neurological or psychiatric pathology are discussed. Several neuroanatomical and psychological models of the déjà vu experience are highlighted, implicating the perceptual, mnemonic and affective regions of the lateral temporal cortex, hippocampus and amygdala in the genesis of déjà vu. A possible genetic basis for a neurochemical model of déjà vu is discussed. Clinical approaches to the patient presenting with possible déjà vu are proposed.

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References

  1. Adachi N, Koutroumanidis M, Elwes R, Polkey C, Binnie C, Reynolds E, Barrington S, Maisey M, Panayiotopoulos C (1999) Interictal 18FDG PET findings in temporal lobe epilepsy with déjà vu. J Neuropsychiatry Clin Neurosci 11(3):380–386

    Google Scholar 

  2. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Association, Washington, D. C., pp 530–532

    Google Scholar 

  3. Arnaud F (1896) Un cas d’illusion du “déjà-vu” ou de “fausse mémoire”. Ann Med Psychol (Paris) 3:455–471

    Google Scholar 

  4. Bancaud J, Brunet-Bourgin F, Chauvel P, Halgren E (1994) Anatomical origin of déjà vu and vivid ‘memories’ in human temporal lobe epilepsy. Brain 117:71–90

    Google Scholar 

  5. Berndt-Larsson H (1931) Über das déjà vu und andere Täuschungen des Bekanntheitsgefühls. Z Gesamte Neurol 136:161–164

    Google Scholar 

  6. Carrington H (1931) “Deja vu”: the sense of the “already seen”. J Am Soc Psychical Res 25:301–306

    Google Scholar 

  7. Chapman A, Mensh I (1951/1952) Déjà-vu experience and conscious fantasy in adults. Psychiatr Q (Suppl) 25–26:163–175

    Google Scholar 

  8. Chari C (1962) Paramnesia and reincarnation. Proc Soc Psychical Res 52:264–286

    Google Scholar 

  9. D’Agostino D, Andermann E, Xiong L (1998) Clinical and pedigree analysis in familial temporal lobe epilepsy (FTLE). Epilepsia 39(Suppl 6):S177

    Google Scholar 

  10. De Nayer A (1979) Le déjà vu: élaboration d’un modèle d’approche hypothétique. Psychiatr Clin 12:92–96

    Google Scholar 

  11. Dickens C (1849) David Copperfield. Oxford World Classics, Oxford (1999), p 638

  12. Fertig E, Lincoln A, Martinuzzi A, Mattson RH, Hisama FM (2003) Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features. Neurology 60(10):1687–1690

    PubMed  Google Scholar 

  13. Freud S (1995) The interpretation of dreams. In: Strachey J (ed) The Complete Psychological Works of Sigmund Freud, vol 5. Hogarth Press, London (1995), p 399

  14. Freud S (1995) The psychopathology of everyday life. In: Strachey J (ed) The Complete Psychological Works of Sigmund Freud, vol 6. Hogarth Press, London, pp 265–268

  15. Gambardella A, Messina D, Le Piane E, Oliveri RL, Annesi G, Zappia M, Andermann E, Quattrone A, Aguglia U (2000) Familial temporal lobe epilepsy autosomal dominant inheritance in a large pedigree from southern Italy. Epilepsy Res 38(2–3):127–132

    Google Scholar 

  16. Gloor P (1990) Experiential phenomena of temporal lobe epilepsy. Facts and hypotheses. Brain 113(6):1673–1694

    Google Scholar 

  17. Gloor P (1991) Neurobiological substrates of ictal behavioural changes. In: Smith D, Treiman D, Trimble M (eds) Neurobehavioural problems in epilepsy, vol 55. Raven Press, New York, pp 1–34

  18. Gloor P, Olivier A, Quesney LF, Andermann F, Horowitz S (1982) The role of the limbic system in experiential phenomena of temporal lobe epilepsy. Ann Neurol 12(2):129–144

    Google Scholar 

  19. Goldman-Rakic PS (1988) Changing concepts of cortical connectivity: parallel distributed cortical networks. In: Rakic P, Singer W (eds) Neurobiology of neocortex. John Wiley, Chichester, pp 177–202

  20. Goldman-Rakic PS (1988) Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci 11:137–156

    Google Scholar 

  21. Greyson B (1977) Telepathy in mental illness. J Nerv Ment Dis 165:184–200

    Google Scholar 

  22. Halgren E, Walter RD, Cherlow DG, Crandall PH (1978) Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain 101(1):83–117

    Google Scholar 

  23. Hardy T (1872–1873) A pair of blue eyes, vol 2. Penguin Classics, London (1998), p 166

  24. Harper M (1969) Déjà vu and depersonalisation in normal subjects. Aust NZ J Psychiatry 3:67–74

    Google Scholar 

  25. Heller J (1955) Catch-22. Vintage Classics, London (2004), p 235

  26. Heymans G (1906) Weitere Daten über Depersonalisation und “Fausse Reconnaissance”. Z Psychol 43:1–17

    Google Scholar 

  27. Jackson J (1888) On a particular variety of epilepsy (“intellectual aura”), one case with symptoms of organic brain disease. Brain 11:179–207

    Google Scholar 

  28. Jensen J (1868) Uber Doppelwahrnehmungen in der gesunden wie in der kranken Psyche. Allgemeine Zeitschrift für Psychiatrie und Nervenkrankheiten. Supplement Heft 25:48–64

    Google Scholar 

  29. Jessen P (1855) Versuch einer wissenschaftlichen Begründung der Psychologie. Verlag von Veit and Comp, Berlin, pp 549–550

  30. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, Martinelli Boneschi F, Choi C, Morozov P, Das K, Teplitskaya E, et al. (2002) Mutations in LGI1 cause autosomaldominant partial epilepsy with auditory features. Nat Genet 30(3):335–341

    PubMed  Google Scholar 

  31. Lalande A (1876) Des paramnésies. Révue Philosophique 36:485–497

    Google Scholar 

  32. Maudsley H (1889) The double brain. Mind 54:161–187

    Google Scholar 

  33. McKellar P, Simpson L (1954) Between wakefulness and sleep: hypnagogic imagery. Br J Psychol 45:266–276

    Google Scholar 

  34. Michelucci R, Poza JJ, Sofia V, de Feo MR, Binelli S, Bisulli F, Scudellaro E, Simionati B, Zimbello R, D’Orsi G, et al. (2003) Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families. Epilepsia 44(10):1289–1297

    Google Scholar 

  35. Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S, Saenz A, Poza JJ, Galan J, Gesk S, Sarafidou T, Mautner VF, Binelli S, et al. (2002) Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet 11(9):1119–1128

    Google Scholar 

  36. Mullan S, Penfield W (1959) Illusions of comparative interpretation and emotion. Arch Neurol Psychiatry 81:269–284

    Google Scholar 

  37. Myers F (1895) The subliminal self. Proc Soc Psychical Res 11:334–593

    Google Scholar 

  38. Neppe V (1979) An investigation of the relationship between subjective paranormal experience and temporal lobe symptomatology. University of the Witwatersrand, Johannesburg

  39. Neppe V (1983) The psychology of déjà vu: have I been here before? Witwatersrand University Press, Johannesburg

  40. Oberndorf C (1941) Erroneous recognition. Psychiatr Q 15:316–326

    Google Scholar 

  41. Ottman R, Risch N, Hauser WA, Pedley TA, Lee JH, Barker-Cummings C, Lustenberger A, Nagle KJ, Lee KS, Scheuer ML, et al. (1995) Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet 10(1):56–60

    Google Scholar 

  42. Pickford R (1964) Three related experiences of déjà vu. J Am Soc Psychical Res 58:186–203

    Google Scholar 

  43. Proust M (1919) Within a Budding Grove, Part 2: Place-Names: The Place. In: In Search of Lost Time, vol 4. Vintage Classics, London (1996), pp 343–345

  44. Richardson T, Winokur G (1967) Déjà vu in psychiatric and neurosurgical patients. Arch Gen Psychiatry 17:622–625

    Google Scholar 

  45. Scott W (1890) The Journal of Sir Walter Scott. Canongate Classics, Edinburgh (1998), p 481

  46. Siomopoulos V (1972) Derealization and déjà vu: formal mechanisms. Am J Psychother 26:84–89

    Google Scholar 

  47. Sno H, Linszen D (1990) The déjà vu experience: remembrance of things past? Am J Psychiatry 147(12):1587–1595

    Google Scholar 

  48. Sno H, Schalken H, De Jonghe F, Koeter M (1994) The Inventory for déjà vu experiences assessment. J Nerv Ment Dis 182(1):27–33

    Google Scholar 

  49. Tolstoy L (1859) War and Peace, vol 2. David Campbell, London, p 136

  50. Warren-Gash C, Zeman A (2003) Déjà vu. Practical Neurology 3:106–109

    Google Scholar 

  51. Weinand ME, Hermann B, Wyler AR, Carter LP, Oommen KJ, Labiner D, Ahern G, Herring A (1994) Long-term subdural strip electrocorticographic monitoring of ictal deja vu. Epilepsia 35(5):1054–1059

    Google Scholar 

  52. Wigan A (1844) The duality of the mind. Joseph Simon, Malibu, California (1985), pp 64–65

  53. Winawer MR, Ottman R, Hauser WA, Pedley TA (2000) Autosomal dominant partial epilepsy with auditory features: defining the phenotype. Neurology 54(11):2173–2176

    Google Scholar 

  54. Zuger B (1966) The time of dreaming and the déjà vu. Compr Psychiatry 1966 7:191–196

    Google Scholar 

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Wild, E. Déjà vu in neurology. J Neurol 252, 1–7 (2005). https://doi.org/10.1007/s00415-005-0677-3

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  • DOI: https://doi.org/10.1007/s00415-005-0677-3

Key words

  • déjà vu
  • temporal lobe epilepsy