High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease
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- Romito, L.M.A., Contarino, M.F., Ghezzi, D. et al. J Neurol (2005) 252: 208. doi:10.1007/s00415-005-0638-x
High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson’s disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.
Key wordsneurostimulation deep brain stimulation Parkinson’s disease surgery subthalamic stimulation PARK2 parkin disease
Levodopa equivalent daily dose
Unified Parkinson’s disease rating scale
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