Large artery ischaemic stroke in severe acute respiratory syndrome (SARS)


Of the 206 patients who contracted Severe Acute Respiratory Syndrome (SARS) in Singapore five developed large artery cerebral infarctions. Four patients were critically-ill and three died. Intravenous immunoglobulin was given to three patients. An increased incidence of deep venous thrombosis and pulmonary embolism was also observed among the critically-ill patients. We believe our experience warrants an increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombotic tendency, is contemplated.


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Correspondence to T. Umapathi MRCP.

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This paper is dedicated to the five health care workers who lost their lives in the outbreak of SARS in Singapore.

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Umapathi, T., Kor, A.C., Venketasubramanian, N. et al. Large artery ischaemic stroke in severe acute respiratory syndrome (SARS). J Neurol 251, 1227–1231 (2004).

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Key words

  • SARS
  • stroke
  • hypercoagulable state