Abstract
We used transcranial magnetic stimulation to evaluate cortical excitability in acute exacerbations of chronic obstructive pulmonary disease (COPD). Patients affected by COPD were studied during acute exacerbation that required hospital admission and 3-4 months after oxygen therapy. Their data were compared with those of age-matched healthy controls. Intracortical inhibition and cortical silent period duration were significantly reduced in patients during acute exacerbation of COPD. These findings could reflect impairment of GABAergic cortical circuits during hypoxia.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 5 September 2001, Received in revised form: 10 January 2002, Accepted: 28 February 2002
Rights and permissions
About this article
Cite this article
Oliviero, A., Corbo, G., Tonali, P. et al. Functional involvement of central nervous system in acute exacerbation of chronic obstructive pulmonary disease. J Neurol 249, 1232–1236 (2002). https://doi.org/10.1007/s00415-002-0817-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-002-0817-y