Abstract
Six patients with recurrent or progressive anaplastic oligodendroglial tumors after surgical treatment and irradiation were treated with six/seven cycles of intensified PCV: Vincristine (1 mg/m2), CCNU (50 mg/m2) d.1,15 and procarbazine (75 mg/m2) d.2 to 29. If leukocytopenia (< 2.500/μl) or thrombocytopenia (< 75.000/μl) developed, 1 × 106 CD34+ autologous stem cells/ kg body weight were reinfused three days after completion of subsequent cycles. Complete response was seen in 2/6 and partial response in 4/6 patients. Median follow up from time of recurrence was 35 months, progression free survival was 18 to > 39 months and overall survival 23 to > 39 months. We conclude that intensified PCV with stem cell support is feasable in recurrent/progressive anaplastic oligodendroglial tumors and appears to be sufficiently well tolerated to allow further study.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 5 September 2001 Received in revised form: 28 January 2002 Accepted: 20 February 2002
Rights and permissions
About this article
Cite this article
Zander, T., Nettekoven, W., Kraus, J. et al. Intensified PCV-chemotherapy with optional stem cell support in recurrent malignant oligodendroglioma. J Neurol 249, 1055–1057 (2002). https://doi.org/10.1007/s00415-002-0794-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-002-0794-1