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Neostigmine-induced alterations in fast phase of optokinetic responses in myasthenic ocular palsies

Journal of Neurology volume 249, pages 867–874 (2002)Cite this article

Abstract.

Closed-loop and open-loop optokinetic nystagmus (OKN) eye movements were recorded with an electromagnetic scleral search coil in 16 patients with myasthenic ocular palsies, 8 patients with nonmyasthenic ocular palsies, and 4 normal controls. We calculated the summation of fast-phase amplitude per second (SFPAps), mean of fast-phase amplitude (MFPA) and mean of fast-phase peak velocity (MFPV) of OKN before and after administration of neostigmine. Under open-loop conditions, the myasthenic patients group demonstrated distinct increases in three parameters: SFPAps (P < 0.000001), MFPA (P < 0.001) and MFPV (P < 0.001) following neostigmine injection, and the increase in SFPAps was greater than those of MFPA and MFPV (P < 0.02), while the other two groups showed no significant increases. Under closed-loop condition, only five of the myasthenic patients showed significant changes. These results suggest that the change in SFPAps during open-loop OKN before and after neostigmine administration was a specific measurement that differentiated patients with myasthenic ocular palsies from the other groups.

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Affiliations

  1. Laboratory of Neurobiology of Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China. Tel.: +86-21/6 43 70-0 80 ext. -1 52, Fax: +86-21/6 43 32-4 45, E-Mail: fcsun@server.shcnc.ac.cn, CN

    Jing Tian, Qing Yang, Min Wei, Joseph Terdiman & Fuchuan Sun

Authors
  1. Jing Tian
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  2. Qing Yang
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  3. Min Wei
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  4. Joseph Terdiman
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  5. Fuchuan Sun
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Additional information

Received: 16 June 2001, Received in revised form: 3 January 2002, Accepted: 14 January 2002

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Tian, J., Yang, Q., Wei, M. et al. Neostigmine-induced alterations in fast phase of optokinetic responses in myasthenic ocular palsies. J Neurol 249, 867–874 (2002). https://doi.org/10.1007/s00415-002-0750-0

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  • DOI: https://doi.org/10.1007/s00415-002-0750-0

  • Key words myasthenia gravis
  • optokinetic nystagmus
  • open-loop
  • neostigmine
  • fast-phase amplitude