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Molecular analysis of thrombophilic risk factors in patients with dural arteriovenous fistulas

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Dural arteriovenous fistulas (DAVFs) are direct artery-to-cerebral venous sinus shunts. Our recent finding of a significantly increased prevalence of factor V (FV) Leiden in patients with DAVFs prompted us to evaluate prothrombinG20210A, MTHFRC677T, β-fibrinogenG455A, PAI-14G/5G and FXIIIVal34Leu as additional risk factors for thrombophilia in 26 patients with DAVFs and a group of age- and gender-matched controls. There was no significantly increased prevalence of these risk factors in DAVF patients. We conclude that FV Leiden is of pathogenetic significance in the aetiology of a subgroup of DAVFs whereas the other thrombophilic risk factors are not likely to be involved.

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Received: 15 July 2001, Received in revised form: 16 October 2001, Accepted: 23 October 2001

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Kraus, J., Stüper, B., Müller, J. et al. Molecular analysis of thrombophilic risk factors in patients with dural arteriovenous fistulas. J Neurol 249, 680–682 (2002).

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