Skip to main content
SpringerLink
Log in

Genetic structure and forensic characteristics of the Kyrgyz population from Kizilsu Kirghiz autonomous prefecture based on autosomal DIPs

  • Population Data
  • Published:
International Journal of Legal Medicine Aims and scope Submit manuscript

Abstract

Living in the heart of Eurasia, the Kyrgyz ethnic minority have a complex human evolutionary and migration history. However, the genetic architecture of the Kyrgyz population has not been fully explored. We studied 526 Kyrgyz samples from Kizilsu Kirghiz Autonomous Prefecture in Xinjiang using the Investigator® DIPplex kit. All loci followed Hardy-Weinberg equilibrium (HWE). The combined power of discrimination (CPD) and combined power of paternity exclusion (CPE) was 0.9999999999988 and 0.9936, respectively. Compared with 90 reference populations, five InDels (HLD99, HLD81, HLD64, HLD118, and HLD111) have the potential to distinguish the Kyrgyz/Uyghur/Kazak population from other East Asian populations. Our results suggested a close genetic relationship between the Kyrgyz population and the Uyghur/Kazak populations, followed by South Asian populations. This was in accordance with the inland migration hypothesis or modern human migration influenced by warfare. Overall, this system can be used as a powerful tool in forensic individual identification and as a complementary tool in paternity cases and biogeographic ancestry analyses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Feng QD, Lu Y, Ni XM, Yuan K, Yang YJ, Yang X, Liu C, Lou HY, Ning ZL, Wang YC, Lu DS, Zhang C, Zhou Y, Shi M, Tian L, Wang XJ, Zhang X, Li J, Khan A, Guan YQ, Tang K, Wang SJ, Xu SH (2017) Genetic history of Xinjiang's Uyghurs suggests bronze age multiple-way contacts in Eurasia. Mol Biol Evol 34(10):2572–2582. https://doi.org/10.1093/molbev/msx177

    Article  CAS  PubMed  Google Scholar 

  2. Xie M, Song F, Li J, Lang M, Luo H, Wang Z, Wu J, Li C, Tian C, Wang W, Ma H, Song Z, Fan Y, Hou Y (2019) Genetic substructure and forensic characteristics of Chinese Hui populations using 157 Y-SNPs and 27 Y-STRs. Forensic Sci Int Genet 41:11–18. https://doi.org/10.1016/j.fsigen.2019.03.022

    Article  CAS  PubMed  Google Scholar 

  3. Guo Y, Chen C, Xie T, Cui W, Meng H, Jin X, Zhu B (2018) Forensic efficiency estimate and phylogenetic analysis for Chinese Kyrgyz ethnic group revealed by a panel of 21 short tandem repeats. R Soc Open Sci 5(6):172089. https://doi.org/10.1098/rsos.172089

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Peng MS, Xu WF, Song JJ, Chen X, Sulaiman X, Cai LH, Liu HQ, Wu SF, Gao Y, Abdulloevich NT, Afanasevna ME, Ibrohimovich KB, Chen X, Yang WK, Wu M, Li GM, Yang XY, Rakha A, Yao YG, Upur H, Zhang YP (2018) Mitochondrial genomes uncover the maternal history of the Pamir populations. Eur J Hum Genet 26(1):124–136. https://doi.org/10.1038/s41431-017-0028-8

    Article  CAS  PubMed  Google Scholar 

  5. Zhan XN, Adnan A, Zhou YZ, Khan A, Kasim K, McNevin D (2018) Forensic characterization of 15 autosomal STRs in four populations from Xinjiang, China, and genetic relationships with neighboring populations. Sci Rep 8:4673. https://doi.org/10.1038/s41598-018-22975-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Guo YX, Chen C, Jin XY, Cui W, Wei YY, Wang HD, Kong TT, Mu YL, Zhu BF (2018) Autosomal DIPs for population genetic structure and differentiation analyses of Chinese Xinjiang Kyrgyz ethnic group. Sci Rep 8:11054. https://doi.org/10.1038/s41598-018-29010-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Guo YX, Chen C, Xie T, Cui W, Meng HT, Jin XY, Zhu BF (2018) Forensic efficiency estimate and phylogenetic analysis for Chinese Kyrgyz ethnic group revealed by a panel of 21 short tandem repeats. Roy Soc Open Sci 5(6):172089. https://doi.org/10.1098/rsos.172089

    Article  CAS  Google Scholar 

  8. Li Y, Li X, Chen WY, Fan YJ, Xie MK, Wu J (2019) Allele and haplotype frequencies of 19 X-STRs in the Kyrgyz and Han populations from Kizilsu prefecture. Forensic Sci Int-Gen 40:E259–E261. https://doi.org/10.1016/j.fsigen.2019.02.007

    Article  CAS  Google Scholar 

  9. Li Y, Li X, Chen W, Fan Y, Xie M, Wu J (2019) Allele and haplotype frequencies of 19 X-STRs in the Kyrgyz and Han populations from Kizilsu prefecture. Forensic Sci Int Genet 40:e259–e261. https://doi.org/10.1016/j.fsigen.2019.02.007

    Article  CAS  PubMed  Google Scholar 

  10. Excoffier L, Lischer HE (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and windows. Mol Ecol Resour 10(3):564–567. https://doi.org/10.1111/j.1755-0998.2010.02847.x

    Article  PubMed  Google Scholar 

  11. Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 33(7):1870–1874. https://doi.org/10.1093/molbev/msw054

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Falush D, Stephens M, Pritchard JK (2007) Inference of population structure using multilocus genotype data: dominant markers and null alleles. Mol Ecol Notes 7(4):574–578. https://doi.org/10.1111/j.1471-8286.2007.01758.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. He G, Wang Z, Wang M, Luo T, Liu J, Zhou Y, Gao B, Hou Y (2018) Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestry-informative SNPs. Electrophoresis 39(21):2732–2742. https://doi.org/10.1002/elps.201800019

    Article  CAS  PubMed  Google Scholar 

  14. Underhill PA, Passarino G, Lin AA, Shen P, Mirazon Lahr M, Foley RA, Oefner PJ, Cavalli-Sforza LL (2001) The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Ann Hum Genet 65(Pt 1):43–62. https://doi.org/10.1046/j.1469-1809.2001.6510043.x

    Article  CAS  PubMed  Google Scholar 

  15. Lou H, Li S, Jin W, Fu R, Lu D, Pan X, Zhou H, Ping Y, Jin L, Xu S (2015) Copy number variations and genetic admixtures in three Xinjiang ethnic minority groups. Eur J Hum Genet 23(4):536–542. https://doi.org/10.1038/ejhg.2014.134

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by the National Natural Science Foundation of China (NSFC, No. 81701866) and Postdoctoral Science Foundation of Central South University (No. 229795).

Author information

Authors and Affiliations

  1. Department of Obstetrics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, People’s Republic of China

    Mingkun Xie, Yang Lu & Lirong Liao

  2. Department of Forensic Science, School of Basic Medical Sciences, Xinjiang Medical University, Ürümqi, 830011, China

    Ye Li

  3. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China

    Jin Wu & Feng Song

  4. Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan Province, China

    Jienan Li

Authors
  1. Mingkun Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ye Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jin Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Feng Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yang Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lirong Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jienan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Mingkun Xie or Jienan Li.

Ethics declarations

The study was approved by the Ethics Committee of Sichuan University, and written informed consent was obtained from each participant.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(XLSX 160 kb)

ESM 2

(DOCX 5814 kb)

ESM 3

(DOCX 5320 kb)

ESM 4

(DOCX 4088 kb)

ESM 5

(DOCX 9000 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xie, M., Li, Y., Wu, J. et al. Genetic structure and forensic characteristics of the Kyrgyz population from Kizilsu Kirghiz autonomous prefecture based on autosomal DIPs. Int J Legal Med 136, 539–541 (2022). https://doi.org/10.1007/s00414-020-02277-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00414-020-02277-1

Keywords

Search

Navigation