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Figure. S1
Effect of systemic administration of MDPV (0.01–10 mg/kg i.p.) on isolated mice in the resident–intruder test. Data are expressed as the percentage of variation of the bites given by the mouse (treated with saline or MDPV) compared to its baseline aggressiveness (Fig. 1S, panels A–E). In panels A–E, each bar symbolises the effect of treatment (saline or MDPV) on a single mouse and represents the mean ± SEM of two different time points 15 and 45 minutes following drug administration. At the top of each bar there is a number (from 1 to 5) that indicates the trials in which the animal was treated (see Table 1). The aggressive response of the total number of mice (n°=40) is divided into high- (black bars), normal- (white bars) and low-aggressive animals (grey bars; see materials and methods). (PNG 140 kb)
High resolution image
(TIF 140 kb)
Figure. S2
Effect of systemic administration of cocaine (0.01–10 mg/kg i.p.) on isolated mice in the resident–intruder test. Data are expressed as the percentage of variation of the bites given by the mouse (treated with saline or cocaine) compared to its baseline aggressiveness (Fig. 2S, panels A–E). In panels A–E, each bar symbolises the effect of treatment (saline or cocaine) on a single mouse and represents the mean ± SEM of two different time points 15 and 45 minutes after drug administration. At the top of each bar there is a number (from 1 to 5) that indicates the trials in which the animal was treated (see Table 1). The aggressive response of the total number of mice (n°=40) is divided into high- (black bars), normal- (white bars) and low-aggressive animals (grey bars; see materials and methods). (PNG 121 kb)
High resolution image
(TIF 121 kb)
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De-Giorgio, F., Bilel, S., Ossato, A. et al. Reply to “MDPV-induced aggression in humans not established”. Int J Legal Med 134, 263–265 (2020). https://doi.org/10.1007/s00414-019-02176-0
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DOI: https://doi.org/10.1007/s00414-019-02176-0