Abstract
From Southern Han Chinese samples, we analyzed 19 X-STR markers for linkage, linkage disequilibrium (LD), and mutation rate. The data were collected from two- and three-generation Southern Han Chinese families. These data suggested that both linkage and linkage disequilibrium should be considered while calculating likelihood ratios with X-STR markers in relationship tests. The linkage disequilibrium of these 19 X-STR markers was calculated in our previous research study that was conducted on Southern Han Chinese population. In this study, the recombination fractions between pairs of markers and those obtained from the second-generation Rutgers combined linkage-physical map of the human genome were compared. The observed differences indicated that recombination was not homogeneous along the X chromosome. Therefore, we evaluated the effect on likelihood calculations by referring to haplotype frequencies obtained from allele distributions rather than haplotype counts of Southern Han Chinese population.
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Funding
This study was supported by the Natural Science Foundation of Guangdong Province, China (grant number2014A030310352) as well as the Science and Technology Program of Guangzhou, China (grant 201707010486).
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Human samples were collected after obtaining an approval from the Ethics Committee of the Institute of Forensic Sciences, Ministry of Justice, P. R. China. An informed consent letter was signed by all the participating individuals.
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Yang, X., Chen, Y., Zeng, X. et al. Linkage, recombination, and mutation rate analyses of 19 X-chromosomal STR loci in Chinese Southern Han pedigrees. Int J Legal Med 133, 1691–1698 (2019). https://doi.org/10.1007/s00414-019-02121-1
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DOI: https://doi.org/10.1007/s00414-019-02121-1