Abstract
This study describes autosomal STR profiles of the populations of South and North Afghanistan. A total of 188 unrelated individuals residing north (n = 42) and south (n = 146) of the Hindu Kush Range within the territory of Afghanistan were examined against the background of 54 geographically targeted reference populations from Eurasia and North East Africa. The main objective of this study was to investigate longitudinal gene flow across the Hindu Kush Range and Eurasia. Genetic differentiation tests between North and South Afghanistan generated insignificant genetic differences for all loci. Multidimensional scaling (MDS) plots based on Fst distances and Neighbor-Joining (N-J) analysis indicated genetic affinities between the Afghani groups and Indian/Near East/West Asian populations. Admixture and Structure analyses demonstrate a gradient of genetic continuity within a major east to west cline that includes North and South Afghanistan as intermediate populations. Overall, although Afghanistan is surrounded by a number of natural barriers, instead of an isolated territory, it has been a genetically porous region providing a migrational nexus to the rest of Eurasia.
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References
Dupree L (1964) Prehistoric archeological surveys and excavations in Afghanistan: 1959–1960 and 1961–1963. Science 146:638–640
Tissot, F. Catalogue of the National Museum of Afghanistan 1931–1985, UNESCO Publishing; Afghanistan: hidden treasures from the National Museum, Kabul 2008, pp. 37–53. Eds., Friedrik Hiebert and Pierre Cambon. National Geographic, Washington, D.C.
Runion ML (2007) The history of Afghanistan. Greenwood Press, Connecticut
Elisseeff V (2001) The silk roads: highways of culture and commerce. UNESCO Publishing/Berghahn Books
Berti A, Barni F, Virgili A, Iacovacci G, Franchi C, Rapone C et al (2005) Autosomal STR frequencies in Afghanistan population. J Forensic Sci 50:1494–1496
Carsten H, Schürenkamp M, Börchers T, Eppink M, Brinkmann B (2006) Meiosis study in a population sample from Afghanistan: allele frequencies and mutation rates of 16 STR loci. Int J Legal Med 120:300–302
Älgenäs C, Tillmar AC (2014) Population genetics of 29 autosomal STRs and 17 Y-chromosomal STRs in a population sample from Afghanistan. Intl J Leg Med 128:279–280
Di Cristofaro J, Buhler S, Temori SA, Chiaroni J (2012) Genetic data of 15 STR loci in five populations from Afghanistan. Forensic Sci Int Genet 6:e44–e45
Lacau H, Bukhari A, Gayden T, La Salvia J, Regueiro M et al (2011) Y-STR profiling in two Afghanistan populations. Leg Med (Tokyo) 13:103–108
Lacau H, Gayden T, Regueiro M, Chennakrishnaiah S, Bukhari A, Underhill PA, Garcia-Bertrand RL, Herrera RJ (2012) Afghanistan from a Y-chromosome perspective. Eur J Hum Genet 20(10):1063–1070
Haber M, Platt DE, Ashrafian Bonab M, Youhanna SC, Soria-Hernanz DF, Martínez-Cruz B, Douaihy B, Ghassibe-Sabbagh M, Rafatpanah H, Ghanbari M, Whale J, Balanovsky O, Wells RS, Comas D, Tyler-Smith C, Zalloua PA, The Genographic Consortium (2012) Afghanistan’s ethnic groups share a Y-chromosomal heritage structured by historical events. PLoS One 7:e34288
Cristofaro JD, Pennarun E, Mazières S, Myres NM, Lin AA, Shah Aga Temori SA, Mait M, et al. (2013) Afghan Hindu Kush: where Eurasian sub-continent gene flows converge PLoS One 8:e76748
Rowold DJ, Herrera RJ (2003) Inferring recent phylogenies using forensic STR technology. Forensic Sci Int 133:260–265
Raymond M, Rousset F (1995) GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Hered 86:248–249
Guo S, Thompson E (1992) Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 48:361–372
Excoffier L, Lischer HEL (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour 10:564–567
Hill CR, Duewer DL, Kline MC, Sprecher CJ, McLaren RS, Rabbach DR, Krenke BE, Ensenberger MG, Fulmer PM, Storts DR, Butler JM (2011) Concordance and population studies along with stutter and peak height ratio analysis for the PowerPlex ® ESX 17 and ESI 17 systems. Forensic Sci Int Genet 5(4):269–275
Rousset F (2008) Genepop'007: a complete reimplementation of the Genepop software for Windows and Linux. Mol Ecol Resour 8:103–106
Dunn OJ (1961) Multiple comparisons among means. J Am Stat Assoc 56(293):52–64
Takezaki N, Nei M, Tamura K (2010) POPTREE2: software for constructing population trees from allele frequency data and computing other population statistics with Windows-interface. Mol Biol Evol 27:747–752
Latter BDH (1972) Selection in finite populations with multiple alleles. III. Genetic divergence with centripetal selection and mutation. Genetics 70:475–490
Busing FMTA, Commandeur JJF, Heiser WJ, Bandilla W, Faulbaum F (1997) A multidimensional scaling program for individual differences scaling with constraints. Adv Stat Sftwr 6:67–73
Long JC, Williams RC, McAuley JE, Medis R, Partel R, Tregellas M, South SF, Rea AE, McCormick B, Iwaniec U (1991) Genetic variation in Arizona Mexican Americans: estimation and interpretation of admixture proportions. Am J Phys Anthropol 84:141–157
Nei M (1978) Estimation of average heterozygosity and genetic distance from a small number of individuals. Genetics 89:583–590
Sokal RR, Rohlf FJ (1981) Biometry: the principles and practice of statistics in biological research, 2nd edn. W. H. Freeman, New York
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Luis, J.R., Lacau, H., Fadhlaoui-Zid, K. et al. Afghanistan: conduits of human migrations identified using AmpFlSTR markers. Int J Legal Med 133, 1659–1666 (2019). https://doi.org/10.1007/s00414-019-02018-z
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DOI: https://doi.org/10.1007/s00414-019-02018-z