Forensic molecular genetic diversity analysis of Chinese Hui ethnic group based on a novel STR panel

  • Yating Fang
  • Yuxin Guo
  • Tong Xie
  • Xiaoye Jin
  • Qiong Lan
  • Yongsong Zhou
  • Bofeng Zhu
Population Data

Abstract

In present study, the genetic polymorphisms of 22 autosomal short tandem repeat (STR) loci were analyzed in 496 unrelated Chinese Xinjiang Hui individuals. These autosomal STR loci were multiplex amplified and genotyped based on a novel STR panel. There were 246 observed alleles with the allele frequencies ranging from 0.0010 to 0.3609. All polymorphic information content values were higher than 0.7. The combined power of discrimination and the combined probability of exclusion were 0.999999999999999999999999999426766 and 0.999999999860491, respectively. Based on analysis of molecular variance method, genetic differentiation analysis between the Xinjiang Hui and other reported groups were conducted at these 22 loci. The results indicated that there were no significant differences in statistics between Hui group and Northern Han group (including Han groups from Hebei, Henan, Shaanxi provinces), and significant deviations with Southern Han group (including those from Guangdong, Guangxi provinces) at 7 loci, and Uygur group at 10 loci. To sum up, these 22 autosomal STR loci were high genetic polymorphic in Xinjiang Hui group.

Keywords

Hui group Forensic genetics Genetic polymorphism STR 

Notes

Compliance with ethical standards

This study was subject to approval by the Ethics Committee of Southern Medical University and Xi’an Jiaotong University.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

414_2018_1829_MOESM1_ESM.docx (24 kb)
Table S1 (DOCX 24 kb)
414_2018_1829_MOESM2_ESM.docx (23 kb)
Table S2 (DOCX 23.3 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Forensic Genetics, School of Forensic MedicineSouthern Medical UniversityGuangzhouPeople’s Republic of China
  2. 2.Key laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of StomatologyXi’an Jiaotong UniversityXi’anPeople’s Republic of China
  3. 3.College of Medicine & ForensicsXi’an Jiaotong University Health Science CenterXi’anPeople’s Republic of China

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