Population data and mutation rates of 20 autosomal STR loci in a Chinese Han population from Yunnan Province, Southwest China
The genetic polymorphisms of 20 autosomal short tandem repeat (STR) loci included in the PowerPlex® 21 kit were evaluated from 2068 unrelated, healthy individuals from the Chinese Han population of Yunnan Province in southwest China. All of the loci reached Hardy–Weinberg equilibrium. These loci were examined to determine allele frequencies and forensic statistical parameters. The genetic relationships among the Yunnan Han and other Chinese populations were also estimated. The combined discrimination power and probability of excluding paternity of the 20 STR loci were 0.99999999999999999999999126 and 0.999999975, respectively. In addition, mutation rates from 4363 parentage cases (2215 trios and 2148 duos) were investigated in this study. A total of 164 mutations were observed in 6578 meioses from the 20 loci. The highest mutation rate was observed in D12S391 (0.30%), and the lowest mutation rates were observed in D13S317 (0.03%) and TPOX (0.03%). The average mutation rate for the 20 loci was estimated to be 1.246 × 10−3 per meiosis. The mutations were primarily single-step and paternal mutations.
KeywordsShort tandem repeat (STR) Population data Mutation rate Chinese Han Yunnan Province
We would like to thank the donors who contributed samples for this study and especially thank Hecheng Zheng from Chuxiong Public Security Bureau and Zibing Xiang and Xingui Xu from Wenshan Public Security Bureau for giving help in the process of sample collection.
This work was supported by grants from the Natural Science Foundation of China (31660310), the Science and Technology Planning Projects of Yunnan Province (2013FZ066, 2014FZ005), and the Yunnan Educational Science Foundation Program (2014Y180).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
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