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How many single nucleotide polymorphisms (SNPs) are needed to replace short tandem repeats (STRs) in forensic applications?

International Journal of Legal Medicine volume 131, pages 1203–1210 (2017)Cite this article

Abstract

Short tandem repeats (STRs) are the most commonly used forms of genetic information in forensic identification. In recent times, advances in the information on single nucleotide polymorphisms (SNPs) have raised the possibility that these markers could replace the forensically established STRs. In this work, we conducted comparative simulation studies that allowed us to estimate the number of SNPs needed if these markers were used instead of STRs in criminal cases and paternity investigations.

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Acknowledgements

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2012-0009833), the research project for practical use and advancement of forensic DNA analysis of Supreme Prosecutors’ Office, Republic of Korea (1333-304-260, 2014), and the National Research Foundation (NRF) grant funded by the Korea government (MSIP, 2016943438).

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Affiliations

  1. Product Development HQ, DonaA-ST, 64, Cheonho-daero, Dondaemun-gu, Seoul, South Korea

    Hyo-Jung Lee

  2. Department of Statistics, Korea University, 145, Anam-ro, Sungbuk-gu, Seoul, South Korea

    Jae Won Lee & Su Jin Jeong

  3. Department of Preventive Medicine, Eulji University, 77, Gyeryong-ro, 771beon-gil, Jung-gu, Daejeon, South Korea

    Mira Park

Authors
  1. Hyo-Jung Lee
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  2. Jae Won Lee
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  3. Su Jin Jeong
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  4. Mira Park
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Corresponding author

Correspondence to Mira Park.

Additional information

Hyo-Jung Lee and Jae Won Lee contributed equally to this work.

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Lee, HJ., Lee, J.W., Jeong, S.J. et al. How many single nucleotide polymorphisms (SNPs) are needed to replace short tandem repeats (STRs) in forensic applications?. Int J Legal Med 131, 1203–1210 (2017). https://doi.org/10.1007/s00414-017-1564-z

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  • DOI: https://doi.org/10.1007/s00414-017-1564-z

Keywords

  • Short tandem repeats
  • Single nucleotide polymorphisms